Abstract:
:In complex regional pain syndrome (CRPS) many clinical symptoms suggest involvement of the central nervous system. Neuropathic pain as the leading symptom is often resistant to therapy. In the present study we investigated the analgesic efficiency of repetitive transcranial magnetic simulation (rTMS) applied to the motor cortex contralateral to the CRPS-affected side. Seven out of ten patients reported decreased pain intensities. Pain relief occurred 30 s after stimulation, whereas the maximum effect was found 15 min later. Pain re-intensified increasingly 45 min after rTMS. In contrast, sham rTMS did not alter pain perception. These findings provide evidence that in CRPS I pain perception can be modulated by repetitive motor cortex stimulation.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Pleger B,Janssen F,Schwenkreis P,Völker B,Maier C,Tegenthoff Mdoi
10.1016/j.neulet.2003.11.037keywords:
subject
Has Abstractpub_date
2004-02-12 00:00:00pages
87-90issue
2eissn
0304-3940issn
1872-7972pii
S030439400301365Xjournal_volume
356pub_type
临床试验,杂志文章,随机对照试验abstract::Pitrazepin is a potent new GABA antagonist which differs from bicuculline in its chemical structure and its interaction with both [3H]muscimol and [3H]flunitrazepam binding sites, whereby the potency of pitrazepin in displacing [3H]muscimol exceeds that of bicuculline by at least a factor of 10. In physiological exper...
journal_title:Neuroscience letters
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