Con-T[M8Q] potently attenuates the expression and development of morphine tolerance in mice.

Abstract:

:As a variant of peptide conantokin-T (con-T), con-T[M8Q] is derived from the venom of Conus tulipa. Our previous study has demonstrated that con-T[M8Q] selectively targets N-methyl-d-aspartate receptor (NMDAR) NR2B subunit. In the present study, we determined the effects of con-T[M8Q] on the expression and development of morphine tolerance using hot plate test and acetic acid writhing test. Our results demonstrated that con-T[M8Q] could efficiently attenuate the expression and development of morphine analgesic tolerance in mice at low doses (5-20nmol/kg), and it exhibited more potent effects compared with ifenprodil, a typical small-molecule antagonist of NMDAR. In addition, low doses of con-T[M8Q] (5-20nmol/kg) did not cause drug resistance and apparent analgesic activity compared with morphine. Taken together, con-T[M8Q] could be a promising new candidate in attenuating morphine tolerance.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Ren B,Zhou Z,Liu Z,Li B,Ou J,Dai Q

doi

10.1016/j.neulet.2015.04.023

subject

Has Abstract

pub_date

2015-06-15 00:00:00

pages

38-42

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(15)00312-2

journal_volume

597

pub_type

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