Selective regulation of dendritic MAP2 mRNA levels in hippocampal granule cells by nitric oxide.

Abstract:

:Application of NMDA, or agents releasing nitric oxide (NO), onto the dendrites of hippocampal granule cells increased the levels of the mRNA encoding MAP2, a cytoskeletal component induced during periods of neurite outgrowth. Furthermore, local increases in the hybridisation signal in the molecular layer, representing dendritic MAP2 mRNA, occurred independently of changes in MAP2 mRNA levels in the cell body layer. The selective modulation of MAP2 mRNA in dendrites reveals a mechanism allowing a sustained stimulation of dendritic outgrowth to be confined to those regions of a neuron's dendritic arbour local to glutamate receptor stimulation.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Johnston HM,Morris BJ

doi

10.1016/0304-3940(94)90031-0

subject

Has Abstract

pub_date

1994-08-15 00:00:00

pages

5-10

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(94)90031-0

journal_volume

177

pub_type

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