Alcohol consumption and blood-cerebrospinal fluid barrier dysfunction in man.

Abstract:

:The cerebrospinal fluid (CSF)/serum albumin ratio has been used a marker for blood CSF barrier permeability in 116 normal patients. We attempted to correlate the CSF/serum albumin ratio with a number of clinically measurable parameters including alcohol consumption. Alcohol consumption had a significant effect on the blood-CSF barrier. Our data indicate that alcohol increases blood CSF barrier permeability in a dose-dependent manner. The measured values of parameters indirectly indicative of alcohol consumption, such as gamma-glutamyltranspeptidase (gamma-GT) and erythrocyte mean corpuscular volume (MCV), were also correlated with enhanced blood-CSF barrier permeability. Although an apparent influence of age, body weight and sex on blood-CSF barrier permeability was observed, these correlations were not separable from the effect of alcohol consumption.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Kornhuber J,Kaiserauer CH,Kornhuber AW,Kornhuber ME

doi

10.1016/0304-3940(87)90700-2

subject

Has Abstract

pub_date

1987-08-18 00:00:00

pages

218-22

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(87)90700-2

journal_volume

79

pub_type

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