Vascular endothelial growth factor-B is neuroprotective in an in vivo rat model of Parkinson's disease.

Abstract:

:Developing novel neuroprotective strategies for the treatment of Parkinson's disease (PD) is of great importance. We have previously shown that vascular endothelial growth factor-B (VEGF-B) is up-regulated in an in vitro model of PD using the neurotoxin rotenone. Addition of exogenous VEGF-B(167) was neuroprotective in this same model, suggesting that VEGF-B is a natural response to neurodegenerative challenges. Now we have extended this research using in vivo experiments. We tested a single intra-striatal injection of 3 μg VEGF-B(186), the more diffusible VEGF-B isoform, in a mild progressive unilateral 6-hydroxydopamine (6-OHDA) rat in vivo PD model. Treatment with VEGF-B(186) 6h prior to lesioning with 6-OHDA improved amphetamine-induced rotations and forepaw preference at 2, 4 and 6 weeks post-injection, indicating a neuroprotective effect. Immunohistochemical analysis showed that VEGF-B(186) treatment partially protected dopaminergic fibers in the striatum and demonstrated a partial rescue of the dopaminergic neurons in the caudal sub-region of the substantia nigra. Altogether our data suggest that VEGF-B(186) could be a new candidate trophic factor for the treatment of PD.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Falk T,Yue X,Zhang S,McCourt AD,Yee BJ,Gonzalez RT,Sherman SJ

doi

10.1016/j.neulet.2011.03.088

subject

Has Abstract

pub_date

2011-05-27 00:00:00

pages

43-7

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(11)00423-X

journal_volume

496

pub_type

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