Alterations in acetylcholine-induced stimulation of inositol phospholipid hydrolysis in the dorsal hippocampus of kindled rats.

Abstract:

:Agonist-induced turnover or release of inositolphosphates (IP) was studied in the dorsal and the ventral hippocampus 24 h, 1 month, and 3 months after the last electrical stimulus of kindled rats. A significant increase in acetylcholine (ACh)-stimulated IP turnover was observed in dorsal, but not ventral, hippocampus 24 h and 1 month after the last electrical stimulus. However, this effect was not evident 3 months after kindling. The excitatory amino acids (quisqualic acid and ibotenic acid) at the concentrations used, however, failed to produce any change in receptor-stimulated release or turnover of IP. Thus the changes in ACh-induced IP release, although long-term, are not permanent and do not appear to be released to the neurobiological alterations associated with the long-term maintenance of the kindling phenomenon.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Zhang WQ,Tandon P,Sobotka TJ,Hong JS,Tilson HA

doi

10.1016/0304-3940(90)90248-8

subject

Has Abstract

pub_date

1990-10-02 00:00:00

pages

57-60

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90248-8

journal_volume

118

pub_type

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