Amyloid precursor protein 17-mer peptide ameliorates hippocampal neurodegeneration in ovariectomized rats.

abstract：:This study was designed to investigate the effects of honokiol, a neuroprotective agent, on cerebral edema in cerebral ischemia reperfusion (IR) mice and its mechanism of anti-inflammation. Honokiol (0.7-70μg/kg) significantly reduced brain water contents and decreased the exudation of Evans blue dye from brain capill...

journal_title：Neuroscience letters

authors： Zhang P,Liu X,Zhu Y,Chen S,Zhou D,Wang Y

更新日期：2013-02-08 00:00:00

abstract：:Alzheimer disease (AD) is the most common type of dementia, and is currently incurable. The efficacy of existing treatments for AD such as acetylcholinesterase inhibitors is limited to symptom improvement. Research on disease-modifying therapies (DMTs) has conventionally focused on amelioration of CNS pathogenesis. Tw...

journal_title：Neuroscience letters

authors： Shozawa H,Oguchi T,Tsuji M,Yano S,Kiuchi Y,Ono K

更新日期：2018-06-11 00:00:00

abstract：:Neurodegenerative disorders such as Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by impairment of autophagy. Cellular survival is dependent on efficient clearance of phosphorylated α-synuclein, which accumulates as fibrils in the neuronal cytoplasm as Lewy bodies (LBs). The forkhead b...

journal_title：Neuroscience letters

authors： Miki Y,Tanji K,Mori F,Utsumi J,Sasaki H,Kakita A,Takahashi H,Wakabayashi K

更新日期：2018-09-25 00:00:00

abstract：:Stimulation of murine primary microglia with Toll-like receptor (TLR) agonists enhances their ability to phagocytose and kill bacteria. Here we show that the viral TLR3 agonist poly(I:C) stimulates the release of cyto-/chemokines and nitric oxide by microglia. Poly(I:C) increases microglial phagocytosis and intracellu...

journal_title：Neuroscience letters

authors： Ribes S,Adam N,Ebert S,Regen T,Bunkowski S,Hanisch UK,Nau R

更新日期：2010-09-20 00:00:00

abstract：:Recently, a mitogen activated protein kinase has been implicated in the generation of a phosphorylated paired helical filament (PHF) epitope recognized by the monoclonal antibody AT8. This epitope consists of phosphorylated serines 199 and/or 202 of the human microtubule associated protein tau. Theoretically, aside fr...

journal_title：Neuroscience letters

authors： Vandermeeren M,Lübke U,Six J,Cras P

更新日期：1993-04-16 00:00:00

abstract：:Febrile seizures (FS) are generally defined as seizures taking place during fever. Long-term prognosis, including development of epilepsy and malformation of cognitive function, has been demonstrated after infantile FS. However, the mechanism that triggers seizures in hyperthermic environment is still unclear. We here...

journal_title：Neuroscience letters

authors： Feng B,Tang YS,Chen B,Dai YJ,Xu CL,Xu ZH,Zhang XN,Zhang SH,Hu WW,Chen Z

更新日期：2014-10-03 00:00:00

abstract：:The discrete distribution and pharmacological characteristics of melatonin binding sites in the bovine hippocampus were determined. Autoradiography revealed the presence of melatonin binding sites in the stratum lacunosum-molecularis of the hippocampus (CA1), stratum molecularis of the subiculum and in the enthorhinal...

journal_title：Neuroscience letters

authors： Nonno R,Lucini V,Stankov B,Fraschini F

更新日期：1995-07-14 00:00:00

abstract：:The N-Methyl-D-Aspartate Receptors (NMDARs) are heteromeric cation channels involved in learning, memory, and synaptic plasticity, and their dysregulation leads to various neurodegenerative disorders. Recent evidence has shown that apart from the GluN1/GluN2A and GluN1/GluN2B diheteromeric ion channels, the NMDAR also...

journal_title：Neuroscience letters

authors： Cheriyan J,Balsara RD,Hansen KB,Castellino FJ

更新日期：2016-03-23 00:00:00

abstract：:The reactivity of different narrow electroencephalographic (EEG) frequencies (4-6, 6-8, 8-10 and 10-12 Hz) to three types of emotionally laden film clips (aggressive, sad, neutral) were examined. We observed that different EEG frequency bands responded differently to the three types of film content. In the 4-6 Hz freq...

journal_title：Neuroscience letters

authors： Krause CM,Viemerö V,Rosenqvist A,Sillanmäki L,Aström T

更新日期：2000-05-26 00:00:00

abstract：:We analyzed the participation of N-methyl-d-aspartate (NMDA) receptors in the neuronal damage caused by adult-onset hypothyroidism. Wistar rats were randomly assigned into four groups. The euthyroid group received tap water. The hypothyroid group received methimazole (60 mg/kg) in their drinking water to induce hypoth...

journal_title：Neuroscience letters

authors： Alva-Sánchez C,Becerril A,Anguiano B,Aceves C,Pacheco-Rosado J

更新日期：2009-04-10 00:00:00

abstract：:The pattern of projection of the ventrobasal thalamic complex (VB) upon the neocortical barrel field of normal and reeler mutant mice was determined by orthograde degeneration experiments and by Timm's histochemical method. In both reeler and normal mice the thalamic terminals are concentrated at the midcortical zone ...

journal_title：Neuroscience letters

authors： Caviness VS Jr,Frost DO,Hayes NL

更新日期：1976-09-01 00:00:00

abstract：:myo-Inositol monophosphatase (E.C.3.1.3.25) catalyzes the hydrolysis of myo-inositol 1-phosphate in the presence of Mg2+ at a physiologic pH to form free myo-inositol, maintaining a supply that represents the precursor for inositol phospholipid second messenger signaling systems. In the present study the activity and ...

journal_title：Neuroscience letters

authors： Shimohama S,Tanino H,Sumida Y,Tsuda J,Fujimoto S

更新日期：1998-04-10 00:00:00

abstract：:Cocaethylene is an active cocaine metabolite that targets mammalian neural reward pathways and thus contributes to the reinforcing and addictive properties of ethanol and cocaine. Using gas chromatography-mass spectrometry, we find that fruit flies (Drosophila melanogaster) possess a cellular mechanism through which c...

journal_title：Neuroscience letters

authors： Torres G,Horowitz JM

更新日期：1999-03-26 00:00:00

abstract：:Convergence of cardiac and cutaneous afferents onto neurons in the dorsal horn of the spinal cord was demonstrated in the cat. Responses of neurons to cutaneous stimulation revealed that they were either nociceptive specific (NS) or wide dynamic range (WDR) neurons. NS neurons were located in lamina I and outer zone o...

journal_title：Neuroscience letters

authors： Takahashi M,Yokota T

更新日期：1983-08-08 00:00:00

abstract：:Disturbed motor control of the fingers, as revealed by the response to unexpected loading of an object held in a precision grip, or to finger perturbation during isometric holding, has been studied in patients with Huntington's disease (HD) and in normal subjects. In normal subjects unexpected loading elicited a refle...

journal_title：Neuroscience letters

authors： Fellows S,Schwarz M,Schaffrath C,Dömges F,Noth J

更新日期：1997-04-25 00:00:00

abstract：BACKGROUND:Down syndrome (DS) is caused by either complete or partial triplication of chromosome 21, affecting approximately 1/1000 live births, and it is widely accepted that individuals with DS are more likely to develop dementia of Alzheimer's disease (DAD) compared with the general population. Many studies have inv...

journal_title：Neuroscience letters

authors： Patel A,Rees SD,Kelly MA,Bain SC,Barnett AH,Thalitaya D,Prasher VP

更新日期：2011-01-07 00:00:00

abstract：:The opioid peptide dynorphin A(1-8) (1 micron) increased acetylcholine release from the Torpedo electric organ by approximately twofold. This effect was reversed by the opiate antagonist naloxone. The effect of Dyn A(1-8) on acetylcholine release was found to vary in magnitude with the seasons of the year, with maxima...

journal_title：Neuroscience letters

authors： Oron L,Sarne Y,Michaelson DM

更新日期：1991-04-29 00:00:00

abstract：:[125I]Bolton-Hunter substance P [( 125I]BH-SP) binding sites in rat and human skin were investigated, using quantitative receptor autoradiographic and emulsion autoradiographic methods. [125I]BH-SP binding sites were discretely localized in skin areas anatomically corresponding to dermal papillae, sweat glands, and ha...

journal_title：Neuroscience letters

authors： Deguchi M,Niwa M,Shigematsu K,Fujii T,Namba K,Ozaki M

更新日期：1989-05-08 00:00:00

abstract：:Bound and free acetylcholine (ACh) were measured in frog sartorius muscles by mass fragmentography. Upon incubation of the muscles for 5 min with potassium propionate, which stimulated the release of ACh, there was a 2-fold reduction of bound ACh. In contrast, the amount of free ACh remained unchanged. After 65 min re...

journal_title：Neuroscience letters

authors： Molenaar PC,Polak RL

更新日期：1983-12-30 00:00:00

abstract：:Sickle cell disease (SCD) describes a group of disorders associated with a point mutation in the beta chain of hemoglobin. The mutation leads to the creation of sickle hemoglobin (HbS) and causes distortion of erythrocytes through polymerization under low oxygen, resulting in characteristic sickle red blood cells. Vas...

journal_title：Neuroscience letters

authors： Uhelski ML,Simone DA

更新日期：2019-07-13 00:00:00

abstract：:Familial Alzheimer's disease (AD) due to PSEN1 mutations provides an opportunity to examine AD biomarkers in persons in whom the diagnosis is certain. We describe a 55 year-old woman with clinically probable AD and a novel PSEN1 mutation who underwent genetic, clinical, biochemical and magnetic resonance and nuclear i...

journal_title：Neuroscience letters

authors： Ringman JM,Gylys KH,Medina LD,Fox M,Kepe V,Flores DL,Apostolova LG,Barrio JR,Small G,Silverman DH,Siu E,Cederbaum S,Hecimovic S,Malnar M,Chakraverty S,Goate AM,Bird TD,Leverenz JB

更新日期：2011-01-10 00:00:00

abstract：:Flupirtine is a centrally acting nonopioid analgesic with muscle-relaxant properties. Flupirtine has been found to activate inwardly rectifying potassium conductances and hence to indirectly inhibit the activation of NMDA receptors. NMDA receptor activation is crucial for the induction of long-term potentiation (LTP) ...

journal_title：Neuroscience letters

authors： Azad SC,Eder M,Simon W,Hapfelmeier G,Dodt HU,Zieglgänsberger W,Rammes G

更新日期：2004-11-11 00:00:00

abstract：:Almost all mechanoreceptive neurons in the cortical taste area (CTA) of the rat had receptive fields (RFs) in the oral cavity, except for a few neurons at the border with the primary somatosensory area that had RFs on the contralateral rhinarium or upper lip. About one-third of the mechanoreceptive neurons with RFs in...

journal_title：Neuroscience letters

authors： Ogawa H,Wang XD

更新日期：2002-04-05 00:00:00

abstract：:The diagonal band of Broca (DBB) is involved in cardiovascular control in rats. In the present study, we report the effect of acute and reversible neurotransmission inhibition in the DBB by bilateral microinjection of the nonselective neurotransmission blocker CoCl(2) (1mM, 100 nL) on the cardiac baroreflex response i...

journal_title：Neuroscience letters

authors： Crestani CC,Tavares RF,Alves FH,Resstel LB,Corrêa FM

更新日期：2008-12-26 00:00:00

abstract：:The regional distribution of binding sites labeled by [3H]haloperidol, in the presence of excess spiroperidol, was compared to the regional distribution of receptors labeled by [3H]SCH 23390 and [3H]sulpiride, [3H]SCH 23390 and [3H]sulpiride labeled distinct nuclei, such as the olfactory tubercle, caudate, globus pall...

journal_title：Neuroscience letters

authors： Contreras PC,Quirion R,Gehlert DR,Contreras ML,O'Donohue TL

更新日期：1987-03-31 00:00:00

abstract：:Melatonin modulates adult hippocampal neurogenesis in adult mice. Also, plasma melatonin levels and new neuron formation decline during aging probably causing cognitive alterations. In this study, we analyzed the impact of exogenous supplementation with melatonin in three key events of hippocampal neurogenesis during ...

journal_title：Neuroscience letters

authors： Ramírez-Rodríguez G,Vega-Rivera NM,Benítez-King G,Castro-García M,Ortíz-López L

更新日期：2012-11-14 00:00:00

abstract：:The effect of 4-aminopyridine (4-AP) on long-term potentiation (LTP) was studied in the hippocampal slice preparation of the rat. Field excitatory postsynaptic potentials (EPSPs) were recorded and evoked in the stratum radiatum of the CA1. Both the low frequency EPSP and LTP of the EPSP were significantly increased by...

journal_title：Neuroscience letters

authors： Lee WL,Anwyl R,Rowan M

更新日期：1986-09-25 00:00:00

abstract：:N-[1-(2-Benzo(b)thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine inhibit dopamine (DA) uptake but bind to different sites on the transporter. Their dose-dependent effects (i.p. administration) on extracellular DA levels in the rat striatum were measured by in vivo microdialysis. Both drugs dose-dependently increase...

journal_title：Neuroscience letters

authors： Martin-Fardon R,Arnaud M,Rousseau E,Kamenka JM,Privat A,Vignon J

更新日期：1996-06-28 00:00:00

abstract：:Fluorescent tracers (Nuclear Yellow, True Blue, Fast Blue) were injected, in various combinations, into the globus pallidus and substantia nigra in three marmosets. Examination of perikarya in the ipsilateral neostriatum, well removed from pallidal injection sites, revealed that the predominant pattern was of single-l...

journal_title：Neuroscience letters

authors： Féger J,Crossman AR

更新日期：1984-08-24 00:00:00

abstract：:Synaptotagmin I (Syt I), a possible Ca(2+) sensor for neurotransmitter release, was suggested to be involved in neurite outgrowth of chick dorsal root ganglion (DRG) neurons, based on introduction of the antibody against the C2A domain into cells via mechanical lesions. Recently, however, the functional block antibody...

journal_title：Neuroscience letters

authors： Fukuda M,Mikoshiba K

更新日期：2000-12-01 00:00:00