Abstract：
:Febrile seizures (FS) are generally defined as seizures taking place during fever. Long-term prognosis, including development of epilepsy and malformation of cognitive function, has been demonstrated after infantile FS. However, the mechanism that triggers seizures in hyperthermic environment is still unclear. We here found that the body temperature of rat pups that experienced experimental FS was markedly decreased (∼28°C) after they were removed from the hyperthermic environment. Both the seizure generation and the temperature drop after seizure attack were abolished by either pre-treatment with chlorpromazine (CPZ), which impairs the thermoregulation, or by an electrolytic lesion of the preoptic area and anterior hypothalamus (PO/AH). However, the non-steroidal anti-inflammatory drug celecoxib did not affect the seizure incidence and the decrease in body temperature after seizure attack. In addition, pentobarbital prevented the generation of seizures, but did not reverse the decrease of body temperature after FS. Therefore, our work indicates that an over-regulation of body temperature occurs during hyperthermic environment, and that the dysfunction of thermoregulation in the PO/AH following hyperthermia contributes to the generation of FS.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Feng B,Tang YS,Chen B,Dai YJ,Xu CL,Xu ZH,Zhang XN,Zhang SH,Hu WW,Chen Zdoi
10.1016/j.neulet.2014.08.037subject
Has Abstractpub_date
2014-10-03 00:00:00pages
129-34eissn
0304-3940issn
1872-7972pii
S0304-3940(14)00699-5journal_volume
581pub_type
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