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Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.

Abstract：

:Recent studies have demonstrated that cholesterol metabolism has an important role in Alzheimer's disease (AD) pathogenesis, suggesting that cholesterol-related genes may be significant genetic risk factors for AD. Based on the results of genome-wide screens, along with biological studies, we selected three genes as candidates for AD risk factors: ATP-binding cassette transporter A1 (ABCA1), cholesterol 25-hydroxylase (CH25H) and cholesterol 24-hydroxylase (CH24H). Case-control of North American Caucasians and AD families of Caribbean Hispanic origin were examined. Although excellent biological candidates, the case-control dataset did not support the hypothesis that these three genes were associated with susceptibility to AD. Similarly, no association was found in the Caribbean Hispanic families for CH25H. However, we did observe a possible interaction between ABCA1 and APOE in the Hispanics.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Shibata N,Kawarai T,Lee JH,Lee HS,Shibata E,Sato C,Liang Y,Duara R,Mayeux RP,St George-Hyslop PH,Rogaeva E

doi

10.1016/j.neulet.2005.08.048

keywords:

subject

Has Abstract

pub_date

2006-01-02 00:00:00

pages

142-6

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(05)00993-6

journal_volume

391

pub_type

杂志文章

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