Abstract:
:We studied the effect of synthetic rat alpha-atrial natriuretic polypeptide (1-28) (ANF-(99-126)) and related atrial natriuretic polypeptides on the accumulation of cyclic GMP (cGMP) in isolated rat choroid plexus in vitro, the objective being to determine whether ANF-(99-126) binding sites are physiologically active receptors. One microM of ANF-(99-126) increased the level of cGMP within 30 s and the accumulation reached the maximum level 5 min after adding of ANF-(99-126) to the incubation media. Significant increase in the level of cGMP depended on concentrations of the ANF-(99-126), ANF-(101-126) and ANF-(103-125), with a range of 10.0 nM to 10.0 microM. These data indicate that binding sites for ANF-(99-126) in the rat choroid plexus may be physiologically active receptors, possibly linked to the production of cerebrospinal fluid.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tsutsumi K,Niwa M,Kawano T,Ibaragi M,Ozaki M,Mori Kdoi
10.1016/0304-3940(87)90692-6subject
Has Abstractpub_date
1987-08-18 00:00:00pages
174-8issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(87)90692-6journal_volume
79pub_type
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