Abstract:
:The 5-HT(1A) receptor agonist 8-OH-DPAT (0.5mg/kg) enhances behavioral recovery when administered 15min after experimental traumatic brain injury (TBI). To determine if benefits are still attainable at clinically relevant times, treatment was delayed 1 and 2h post-TBI and motor/cognitive performance was compared to early (i.e., 15min) administration. No differences were observed among the vehicle and 8-OH-DPAT groups treated at 1 and 2h, but all three were significantly impaired versus early 8-OH-DPAT. The data suggest that an early and narrow critical period exists for the behavioral recovery afforded by a single 8-OH-DPAT treatment paradigm. The critical window corresponds to the well documented TBI-induced glutamate increase, suggesting that 8-OH-DPAT may be conferring neuroprotection by attenuating this acute deleterious surge.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cheng JP,Aslam HA,Hoffman AN,Zafonte RD,Kline AEdoi
10.1016/j.neulet.2007.02.006subject
Has Abstractpub_date
2007-04-12 00:00:00pages
165-8issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(07)00147-4journal_volume
416pub_type
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