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Interferon-alpha, beta and -gamma induce (2'-5') oligoadenylate synthetase in cultured mouse brain cells.

Abstract：

:Basal and interferon (IFN)-induced levels of (2'-5') oligoadenylate synthetase activity were measured in astrocyte cultures from the mouse cerebral cortex, in neurone-enriched and mixed cerebellar cultures, and in two continuous neural cell lines by a radioimmunoassay procedure. All untreated cultures contained measureable enzyme activity. Both purified IFN-alpha, beta and recombinant IFN-gamma induced the enzyme in all cultures with the exception of the C8S cell line which did not respond to IFN-gamma. IFN-alpha, beta was more effective than IFN-gamma. The amplitude of induction by IFN-alpha, beta was highest in the cell lines, intermediate in cortical astrocytes and lowest in mixed and neurone-enriched cultures from the cerebellum.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Hirsch MR,Cailla H,Wietzerbin J,Goridis C

doi

10.1016/0304-3940(86)90293-4

subject

Has Abstract

pub_date

1986-04-11 00:00:00

pages

139-44

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(86)90293-4

journal_volume

65

pub_type

杂志文章

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