Neuroleptic suppression of feeding and oral stereotypy following microinjections of carbachol into substantia nigra.

abstract：:The hypothesis involving glutamate in the neuropathology of schizophrenia has attracted great interest. Several studies report dysfunctions in glutamatergic systems, including alterations in kainate and N-methyl-D-aspartate (NMDA) receptors in various areas, as well as changes in the number of glutamate uptake sites. ...

journal_title：Neuroscience letters

authors： Aparicio-Legarza MI,Cutts AJ,Davis B,Reynolds GP

更新日期：1997-08-22 00:00:00

abstract：:Treatment with agmatine, decarboxylated arginine, proved to be non-toxic and to exert neuroprotective effects in several models of neurotoxic and ischemic brain and spinal cord injuries. Here we sought to find out whether agmatine treatment would also prove beneficial in a rat spinal cord ischemia model (balloon occlu...

journal_title：Neuroscience letters

authors： Gilad GM,Gilad VH

更新日期：2000-12-22 00:00:00

abstract：:Oxytoxin (OT) promotes social behavior and reduces anxiety. A great number of studies suggest that OT plays a role in learning and memory processes in animals and humans. Fear memories are rendered labile and prone to modification after reactivation and a restabilization and reconsolidation process is necessary for fu...

journal_title：Neuroscience letters

authors： Hou Y,Zhao L,Zhang G,Ding L

更新日期：2015-05-06 00:00:00

abstract：:Vigabatrin (VGB, gamma-vinyl-gamma-aminobutyric acid (GABA)), an irreversible inhibitor of GABA transaminase, increases regional inhibitory effects by elevating GABA concentration and reducing glutamate synthesis. In the present study, changes in glutamate dehydrogenase (GDH) activity and its immunoreactivity in the s...

journal_title：Neuroscience letters

authors： Kang TC,An SJ,Park SK,Hwang IK,Choi SY,Kwon OS,Won MH

更新日期：2003-04-10 00:00:00

abstract：:Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in the human diet. Recently, it is demonstrated to have potent antinociceptive effect. However, little is understood about the mechanism underlying CGA analgesia. Here, we have found that CGA can exert an inhibitory effect on the functional activi...

journal_title：Neuroscience letters

authors： Qu ZW,Liu TT,Qiu CY,Li JD,Hu WP

更新日期：2014-05-01 00:00:00

abstract：:Primary neuron cultures are widely used in research due to the ease and usefulness of observing individual cells. Therefore, it is vital to understand how variations in culture conditions may affect neuron physiology. One potential variation for cultured neurons is a change in intracellular transport. As transport is ...

journal_title：Neuroscience letters

authors： Bauer CT,Shtridelman Y,Lema Tomé CM,Grim JQ,Turner CP,Tytell M,Macosko JC

更新日期：2008-08-22 00:00:00

abstract：:Mutations in coding exons or exon 10 5'-splice-site of the gene for microtubule-associated protein tau can cause chromosome 17-linked frontotemporal dementia and parkinsonism (FTDP-17). We sequenced the 11 coding exons plus exon-intron boundaries of the tau gene in 15 cases of progressive supranuclear palsy (PSP), and...

journal_title：Neuroscience letters

authors： Bonifati V,Joosse M,Nicholl DJ,Vanacore N,Bennett P,Rizzu P,Fabbrini G,Marconi R,Colosimo C,Locuratolo N,Stocchi F,Bonuccelli U,De Mari M,Wenning G,Vieregge P,Oostra B,Meco G,Heutink P

更新日期：1999-10-15 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by amyloid plaques, neuritic degenerations, disturbed glutamatergic neurotransmission and a peculiar inflammatory response. Diffuse plaques develop into neuritic plaques when neurites undergo degeneration in the plaque area. Hyperphosphorylation of tau proteins is a major step...

journal_title：Neuroscience letters

authors： Hüll M,Eistetter J,Fiebich BL,Bauer J

更新日期：1999-02-12 00:00:00

abstract：:Cholinergic influences on attention are well documented and recent evidence indicates that genetic variation in the alpha4beta2 nicotinic receptor affects attentional networks of the brain. Several behavioral and electrophysiological studies have shown that a common polymorphism in the CHRNA4 gene (rs1044396) affects ...

journal_title：Neuroscience letters

authors： Reinvang I,Lundervold AJ,Rootwelt H,Wehling E,Espeseth T

更新日期：2009-04-10 00:00:00

abstract：:Carbonic anhydrase (CA) activity was localized histochemically in the retina and brain of the honeybee drone. A positive reaction that could be inhibited with 10(-5) M acetazolamide was found only in brain glial cells such as those in the lamina and medulla of the optic lobes. In the retina, neither the photoreceptors...

journal_title：Neuroscience letters

authors： Walz B

更新日期：1988-02-15 00:00:00

abstract：:The effects of aging on sex differences in analgesia from the kappa-opioid agonist, U50,488H (U50), were examined in C57BL/6J mice. U50 analgesia can be blocked by the N-methyl-d-aspartate receptor antagonist, MK-801 (MK), in male rodents and gonadectomized females, but not hormonally intact or estrogen-replaced femal...

journal_title：Neuroscience letters

authors： Sternberg WF,Ritchie J,Mogil JS

更新日期：2004-06-10 00:00:00

abstract：:Cat odor elicits defensive responses in rats that are modified by repeated exposure to the odor. We explored the neural correlates of this adaptation using FosB/DeltaFosB immunohistochemistry. Rats were given 3 x60 min exposures to either a worn cat collar (repeated cat odor group) or unworn cat collar (control group)...

journal_title：Neuroscience letters

authors： Staples LG,McGregor IS,Hunt GE

更新日期：2009-09-22 00:00:00

abstract：:Histamine H3 receptors (H3Rs) co-localize with dopamine (DA) D1 receptors (D1Rs) on striatal medium spiny neurons and functionally antagonize D1R-mediated responses. The intra-striatal administration of D1R agonists reduces DA release whereas D1R antagonists have the opposite effect. In this work, a microdialysis meth...

journal_title：Neuroscience letters

authors： Alfaro-Rodriguez A,Alonso-Spilsbury M,Arch-Tirado E,Gonzalez-Pina R,Arias-Montaño JA,Bueno-Nava A

更新日期：2013-09-27 00:00:00

abstract：:Muscle fatigue is known to be associated with a deteriorated muscle coordination and impaired movement performance in variety of voluntary movements. The aim of this study was to investigate the generally underexplored effect of muscle fatigue on both the coordination between grip force (GF; the force component perpen...

journal_title：Neuroscience letters

authors： Emge N,Prebeg G,Uygur M,Jaric S

更新日期：2013-08-29 00:00:00

abstract：:Pargyline, an inhibitor of monoamine oxidase (MAO), prevented 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced inhibition of dihydroxyphenylalanine (DOPA) production by tyrosine hydroxylase (TH) system in rat striatal tissue slices. The result suggests that the metabolism of MPTP in rat striatal tissue slic...

journal_title：Neuroscience letters

authors： Hirata Y,Nagatsu T

更新日期：1985-06-24 00:00:00

abstract：:Antidromic action potentials were recorded from rat paraventricular nucleus (PVN) and supraoptic nucleus neurons following electrical stimulation of the pituitary stalk. Increases in stimulation frequency to 10 or 20 Hz caused progressive increases in antidromic latency and, often, failure of the antidromic potential ...

journal_title：Neuroscience letters

authors： Pittman QJ

更新日期：1983-06-30 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNAs that function as tumor suppressors or oncogenes. MicroRNA-107 (miR-107), a transcriptional target of p53, is deregulated in many cancer cell lines. Here, we showed that miR-107 is down-regulated in glioma tissues and cell lines, in particular, p53-mutated U251 and A172. Tran...

journal_title：Neuroscience letters

authors： Chen L,Zhang R,Li P,Liu Y,Qin K,Fa ZQ,Liu YJ,Ke YQ,Jiang XD

更新日期：2013-02-08 00:00:00

abstract：:The intergeniculate leaflet (IGL) of the lateral geniculate complex is marked by the presence of neuro-peptide Y-containing neurons that project to the suprachiasmatic nuclei (SCN) of the hypothalamus. In the present study, we demonstrate that both the IGL and SCN in the hamster and rat are specifically delineated by ...

journal_title：Neuroscience letters

authors： Morin LP,Johnson RF,Moore RY

更新日期：1989-04-24 00:00:00

abstract：:Doxorubicin, a fluorescent retrograde neurotoxin, killed neurons in the ventral tegmentum and thalamus that were afferent to the injection site in the caudate-putamen. The neurotoxic effects in the ventral tegmentum and thalamus were prevented by a large coronal knife cut caudal to the injection site in the striatum, ...

journal_title：Neuroscience letters

authors： van der Kooy D,Zito KA,Roberts DC

更新日期：1985-01-21 00:00:00

abstract：:Mutations in APP are associated with familial early-onset Alzheimer disease (FAD). Examination of the genomic sequence in one patient with FAD revealed a change located in the axon 17 of the APP gene at position 275329G>A (GenBank accession number: D87675; GI: 2429080); cDNA sequence 2137G>A (GenBank accession number:...

journal_title：Neuroscience letters

authors： Armstrong J,Boada M,Rey MJ,Vidal N,Ferrer I

更新日期：2004-11-11 00:00:00

abstract：:On the basis of the recent cloning of the beta-secretase, the beta-site amyloid precursor protein (APP)-cleaving enzyme (BACE), (Science, 286 (1999) 735), digoxigenin-labelled riboprobes were generated to localize the cellular expression pattern of BACE mRNA in brain sections of transgenic Tg2576 mice, overexpressing ...

journal_title：Neuroscience letters

authors： Bigl M,Apelt J,Luschekina EA,Lange-Dohna C,Rossner S,Schliebs R

更新日期：2000-10-06 00:00:00

abstract：:Responses of extracellular acetylcholine (ACh) release and blood flow in the cerebral cortex in the parietal lobe following focal electrical stimulation of the nucleus basalis of Meynert (NBM) ipsilateral to the parietal cortex were compared in healthy adult (6-8 months) and aged (27-28 months) Fischer-344 rats anesth...

journal_title：Neuroscience letters

authors： Kurosawa M,Sato A,Sato Y

更新日期：1989-05-22 00:00:00

abstract：:An intraperitoneal injection of 0.1 nmol uridine in rats resulted in a transient excess slow-wave sleep if administered shortly before onset of the dark period. The sleep latency was remarkably shortened. A small dose (0.01 nmol) and larger doses (1, 10, 100 nmol) caused no effect. Uridine at a dose of 0.1 nmol was en...

journal_title：Neuroscience letters

authors： Honda K,Okano Y,Komoda Y,Inoué S

更新日期：1985-11-20 00:00:00

abstract：:The pathophysiology of Parkinson's disease exhibit imperative roles in unfolded protein response stress-induced oxidative stress and inflammation in general. Although, delta opioid receptor (DOR), has been found to represent anti-parkinsonian effect at behavioral level, its underlying mechanism remains elusive till da...

journal_title：Neuroscience letters

authors： Begum M ET,Sen D

更新日期：2018-06-21 00:00:00

abstract：:Presenilin-1 (PSEN1) mutations I143T and G384A give rise to severe early onset Alzheimers's disease in two extensively studied Belgian families, AD/A and AD/B. In this study we investigated the influence of the I143T and G384A mutations on PSEN1 proteolytic processing. Hereto we analyzed PSEN1 processing in lymphoblas...

journal_title：Neuroscience letters

authors： Vanderhoeven I,Cras P,Martin JJ,Van Broeckhoven C,De Jonghe C

更新日期：1999-10-29 00:00:00

abstract：:Several constituents of chromaffin granules were quantitatively determined in noradrenaline and adrenaline cells purified from bovine adrenal medulla. As far as secretory peptides are concerned noradrenaline granules contained slightly more secretogranin II, but much less chromogranin A than adrenaline granules. This ...

journal_title：Neuroscience letters

authors： Weiss C,Cahill AL,Laslop A,Fischer-Colbrie R,Perlman RL,Winkler H

更新日期：1996-06-14 00:00:00

abstract：:Reactive oxygen species (ROS) are implicated in the pathogenesis of multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). The effect of edaravone, a free radical scavenger, on EAE was investigated in this study. Treatment with edaravone significantly ameliorated the clinical sev...

journal_title：Neuroscience letters

authors： Moriya M,Nakatsuji Y,Miyamoto K,Okuno T,Kinoshita M,Kumanogoh A,Kusunoki S,Sakoda S

更新日期：2008-08-08 00:00:00

abstract：:Melatonin is a tryptophan metabolite synthesized by the pineal gland. Recent research showed that melatonin has a protective effect in Alzheimer's disease (AD). However, its exact mechanism is still unclear. This study was designed to investigate the effects of long-term oral melatonin on spatial learning and memory, ...

journal_title：Neuroscience letters

authors： Sun C,Qiu X,Wang Y,Liu J,Li Q,Jiang H,Li S,Song C

更新日期：2020-09-14 00:00:00

abstract：:Parkin gene mutations are by far the most common mutations in both familial Parkinson's disease (PD) and sporadic PD. Approximately, 50% of parkin mutations is exon dosage mutations (i.e., deletions and duplications of entire exons). Here, we first established a MLPA assay for quick detection of parkin exon rearrangem...

journal_title：Neuroscience letters

authors： Guo JF,Dong XL,Xu Q,Li N,Yan XX,Xia K,Tang BS

更新日期：2015-09-14 00:00:00

abstract：:Whole-cell recordings were obtained from respiratory neurons by applying patch-clamp techniques in the en bloc medulla of in vitro neonatal rat brainstem-spinal cord preparations. Stable voltage-clamp recordings of excitatory or inhibitory synaptic drive currents and current-clamp recordings of spike discharge of insp...

journal_title：Neuroscience letters

authors： Smith JC,Ballanyi K,Richter DW

更新日期：1992-01-06 00:00:00