Sleep-promoting effects of intraperitoneally administered uridine in unrestrained rats.

abstract：:Although the coadministration of lidocaine with propranolol interferes with the metabolic profile (pharmacokinetics), its pharmacodynamics is still unclear. In this report, we investigate whether propranolol can potentiate the effect of lidocaine. Rats received spinal anesthesia with lidocaine co-injected with propran...

journal_title：Neuroscience letters

authors： Chen YW,Chu CC,Chen YC,Hung CH,Li YT,Wang JJ

更新日期：2011-09-26 00:00:00

abstract：:The Rose Bengal model in rats is widely used to study brain plasticity, functional recovery and restorative therapies. The present study evaluated temporal profiles of hemorrhage and edema by magnetic resonance imaging (MRI) in rats in relation to sensorimotor impairment after photochemically induced cortical infarct....

journal_title：Neuroscience letters

authors： Jolkkonen J,Jokivarsi K,Laitinen T,Gröhn O

更新日期：2007-11-27 00:00:00

abstract：:The influence of testosterone on the postnatal development of reflex electromyographic (EMG) jaw muscle activity evoked by injection of mustard oil (MO) into the temporomandibular joint region and the later recurrence of this EMG activity after intravenous injection of naloxone, was studied in male rats. MO-evoked EMG...

journal_title：Neuroscience letters

authors： Seo K,Fujiwara N,Cairns BE,Someya G

更新日期：2002-12-25 00:00:00

abstract：:A paired-pulse stimulus protocol was used to measure angular bundle to dentate gyrus paired-pulse inhibition in rats before and after the occurrence of 36 or 72 seizures elicited from the contralateral CA3 region. The seizures showed progressive lengthening. There was a moderate increase in paired-pulse depression 1 h...

journal_title：Neuroscience letters

authors： Stringer JL,Lothman EW

更新日期：1989-10-23 00:00:00

abstract：:The effect of dopamine on the 3',5'-cyclic adenosine monophosphate (cAMP) generating system of membrane particles of rat prostate gland was studied. Dopamine increased the concentration of cAMP in a dose-dependent manner. The selective D1 receptor inhibitor SCH 23390 caused a decrease in dopamine-elicited cAMP levels....

journal_title：Neuroscience letters

authors： Amenta D,Cavallotti C,Amenta F

更新日期：1987-06-01 00:00:00

abstract：:The pharmacology of the metabotropic glutamate receptor (mGluR)-mediated potentiation of N-methyl-D-aspartate (NMDA)-evoked depolarisations in the CA1 region of rat hippocampal slices was investigated using an extracellular grease-gap method. The group I and II mGluR agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxyli...

journal_title：Neuroscience letters

authors： Fitzjohn SM,Irving AJ,Palmer MJ,Harvey J,Lodge D,Collingridge GL

更新日期：1996-01-26 00:00:00

abstract：:One of the clinical characteristics of psychogenic tremors (PT) is the disruption or transient cessation of tremor with distractive manoeuvres, including those involving the performance of voluntary movements with the contralateral hand. Seven patients with PT, 11 patients with Parkinson's disease (PD), 10 patients wi...

journal_title：Neuroscience letters

authors： Kumru H,Valls-Solé J,Valldeoriola F,Marti MJ,Sanegre MT,Tolosa E

更新日期：2004-11-11 00:00:00

abstract：:Foetal rat mesencephalic dopamine-containing tissue was transplanted into the lateral ventricle of mice previously subjected to a 6-OHDA lesion of dopaminergic nerve terminals in the corpus striatum. The graft recipients were immunosuppressed by subcutaneous injections of 15-deoxyspergualin (DSG). Four weeks postgraft...

journal_title：Neuroscience letters

authors： Zhou J,Date I,Sakai K,Yoshimoto Y,Furuta T,Asari S,Ohmoto T

更新日期：1993-11-26 00:00:00

abstract：:The type of glass used to fabricate patch pipettes influences the kinetic properties of single-channel currents activated by acetylcholine in Xenopus myocytes. In patches formed with hard glass pipettes, the opening rate decreased in a time-dependent manner. Such decrease was most pronounced for the low-conductance ch...

journal_title：Neuroscience letters

authors： Rojas L,Zuazaga C

更新日期：1988-05-16 00:00:00

abstract：:Motor nerve supplies to 15 poles of rat lumbrical spindle were reconstructed from serial, 1-micron transverse sections of muscle embedded in resin. Neural and muscular elements associated with the modulation of static sensitivity of afferents were deficient in these spindles relative to cat tenuissimus and rat soleus ...

journal_title：Neuroscience letters

authors： Walro JM,Kucera J

更新日期：1985-09-06 00:00:00

abstract：:The effects of maternal deprivation (MD) during early postnatal life on the brain-derived neurotrophic factor (BDNF) level were investigated in the present study. Wistar rats were assigned to either maternal deprivation or mother-reared control (MRC) groups. MD manipulation was achieved by separating rat pups from the...

journal_title：Neuroscience letters

authors： Kuma H,Miki T,Matsumoto Y,Gu H,Li HP,Kusaka T,Satriotomo I,Okamoto H,Yokoyama T,Bedi KS,Onishi S,Suwaki H,Takeuchi Y

更新日期：2004-11-30 00:00:00

abstract：:The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas. ...

journal_title：Neuroscience letters

authors： Devor M

更新日期：1983-09-30 00:00:00

abstract：:In rodents the vomeronasal system plays an important role in modulating the hypothalamic control of gonadotropin secretion. It is accepted that the anatomical pathways by which the vomeronasal organ influences the neuroendocrine aspects of the reproductive behavior involves a polysynaptic system, including the accesso...

journal_title：Neuroscience letters

authors： Larriva-Sahd J,Rondán A,Orozco-Estévez H,Sánchez-Robles MR

更新日期：1993-11-26 00:00:00

abstract：:The hippocampus is a brain structure specifically vulnerable to short periods of transient cerebral ischemia, and which displays delayed neuronal necrosis. Protein ubiquitination is a posttranslational modification of proteins and an important factor in heat shock response and a regulator of ATP-dependent protein degr...

journal_title：Neuroscience letters

authors： Magnusson K,Wieloch T

更新日期：1989-01-30 00:00:00

abstract：:In animal models endogenous cannabinoids have an inhibitory effect on trigeminovascular activation through the cannabinoid receptor 1 (CB1), although there is no evidence of the potential role of CB1 in human migraine. In this study we applied single marker association and haplotypic trend regression analysis to inves...

journal_title：Neuroscience letters

authors： Juhasz G,Lazary J,Chase D,Pegg E,Downey D,Toth ZG,Stones K,Platt H,Mekli K,Payton A,Anderson IM,Deakin JF,Bagdy G

更新日期：2009-09-18 00:00:00

abstract：:The pedunculopontine tegmental nucleus (PPTg) contains cholinergic neurons whose principal ascending connections are with thalamic nuclei and structures associated with the striatum. It has been hypothesized that PPTg neurons are more closely associated with the substantia nigra (and therefore striatal motor systems) ...

journal_title：Neuroscience letters

authors： Jenkins TA,Latimer MP,Alderson HL,Winn P

更新日期：2002-03-29 00:00:00

abstract：:Changes in the distribution pattern of mRNA encoding the zif268 transcription factor (also referred to as NGFI-A, Krox-24 or EGR-1) were investigated by in situ hybridization histochemistry during postnatal rat brain development. Marked changes in zif268 expression patterns were seen in particular in the cerebral cort...

journal_title：Neuroscience letters

authors： Herms J,Zurmöhle U,Schlingensiepen R,Brysch W,Schlingensiepen KH

更新日期：1994-01-03 00:00:00

abstract：:The adenosine triphosphate (ATP)-dependent sodium/potassium pump extrudes intracellular sodium in exchange for extracellular potassium. Low ATP causes pump dysfunction increasing both intracellular sodium and water thereby enhancing metabolite mobility. This should be detectable by proton magnetic resonance spectrosco...

journal_title：Neuroscience letters

authors： Cady EB,Lorek A,Penrice J,Wylezinska M,Cooper CE,Brown GC,Owen-Reece H,Kirkbride V,Wyatt JS,Osmund E

更新日期：1994-12-05 00:00:00

abstract：:The effects of geomagnetic disturbances on urinary excretion of the melatonin metabolite, 6-hydroxymelatonin sulfate (6-OHMS), were studied in conjunction with 60 Hz magnetic field (MF) and ambient light exposure in 132 electric utility workers. Geomagnetic activity was assessed using a local (equivalent amplitude or ...

journal_title：Neuroscience letters

authors： Burch JB,Reif JS,Yost MG

更新日期：1999-05-14 00:00:00

abstract：:Extracellular concentration of nitrite (NO2-), an oxidized product of nitric oxide (NO), was measured consecutively in the dorsal region of the rat suprachiasmatic nucleus (SCN) by means of in vivo microdialysis. The NO2- concentrations in the dialysates showed robust circadian rhythm under a 12:12 h light/dark cycle ...

journal_title：Neuroscience letters

authors： Mitome M,Shirakawa T,Oshima S,Nakamura W,Oguchi H

更新日期：2001-05-11 00:00:00

abstract：:Nitric oxide (NO) exerts cytotoxic effects on various cells including neuronal cells. Glial NO production, mediated via induction of inducible NO synthase (iNOS), enhances neurotoxicity associated with the N-methyl-D-aspartate (NMDA) receptor. The present study examined whether nicotinamide, an inhibitor of poly (ADP-...

journal_title：Neuroscience letters

authors： Fujimura M,Tominaga T,Yoshimoto T

更新日期：1997-06-06 00:00:00

abstract：:This study investigated the neuroprotective effects of COG1410, an apoliporotein E (apoE)-derived mimic peptide, against early brain injury (EBI) after subarachnoid hemorrhage (SAH). SAH was induced in C57BL/6J mice (n=68) by endovascular perforation. Mice received intravenous injection of COG1410 (2mg/kg) or equal vo...

journal_title：Neuroscience letters

authors： Wu Y,Pang J,Peng J,Cao F,Vitek MP,Li F,Jiang Y,Sun X

更新日期：2016-08-03 00:00:00

abstract：:In vivo L-band electron spin resonance (ESR) system was used to measure the decay of nitroxide radicals in the living rat cerebrum containing a cortical area with an iron-induced epileptogenic region. Carbamoyl-PROXYL (3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolinyloxy) was injected intraperitoneally. The decay of nitrox...

journal_title：Neuroscience letters

authors： Komatsu M,Hiramatsu M,Yokoyama H,Willmore LJ

更新日期：1996-03-01 00:00:00

abstract：:Recently, researchers have developed protocols for human cerebral organoids using human pluripotent stem cells, which mimic the structure of the developing human brain. Existing research demonstrated that human cerebral organoids which undergo short cultivation periods, contain astrocytes, neurons, and neural stem cel...

journal_title：Neuroscience letters

authors： Matsui TK,Matsubayashi M,Sakaguchi YM,Hayashi RK,Zheng C,Sugie K,Hasegawa M,Nakagawa T,Mori E

更新日期：2018-03-23 00:00:00

abstract：:We tested the hypothesis that intracerebroventricular (i.c.v.) administration of leptin would increase mean arterial pressure (MAP) in ad libitum (AL) fed and food deprived (FD) normotensive rats. Male Sprague-Dawley rats were chronically instrumented with a guide cannula directed at the lateral ventricle and a caroti...

journal_title：Neuroscience letters

authors： Casto RM,VanNess JM,Overton JM

更新日期：1998-04-17 00:00:00

abstract：:Methylmercury (MeHg) is a neurotoxin capable of causing severe damage to the CNS, especially in the developing fetus. Glia in the CNS release a number of cytokines that are important for proper CNS development and function. We reported earlier that MeHg could induce interleukin-6 (IL-6) release in primary mouse glia. ...

journal_title：Neuroscience letters

authors： Chang JY

更新日期：2011-06-08 00:00:00

abstract：:In the present study, we tried to examine whether the 2-deoxy-D-[14C]glucose (2-DG) technique is useful to investigate the metabolic activity of fetal rat brain in the maternal uterus. The result shows that metabolic mapping of the fetal brain was clearly obtained by means of the 2-DG technique. ...

journal_title：Neuroscience letters

authors： Morimoto A,Imai-Matsumura K,Murakami N

更新日期：1990-03-26 00:00:00

abstract：:Acute stress can provoke apoptosis of the retina cells, and up-regulation of calcitonin gene related peptide (CGRP) in retina. However the role of CGRP in the pathology of the stress induced apoptosis of the retina cells is still elusive. The aim of this study was to investigate the endogenous of CGRP on retinal cell ...

journal_title：Neuroscience letters

authors： Yang JH,Zhang YQ,Guo Z

更新日期：2011-08-26 00:00:00

abstract：:A partially purified toxin obtained from the coral reef crab, Lophozozymus pictor was found to be a potent inhibitor of Na+-dependent [14C]-GABA uptake by rat brain synaptosomes. Inhibition was potentiated in the presence of external K+. The I50 value for the toxin was found to be in the region of 10 microgram/ml at a...

journal_title：Neuroscience letters

authors： Tan CH,Abkowitz SJ

更新日期：1979-10-01 00:00:00

abstract：:Selective loss of central dopaminergic neurons in vitro and in vivo can be initiated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) through its metabolite phenylpyridium ion (MPP+). Such MPTP-mediated cytotoxicity can be blocked by (-)-Deprenyl, a monoamine oxidase (MAO)-B inhibitor, but the exact mechanisms o...

journal_title：Neuroscience letters

authors： Le W,Jankovic J,Xie W,Kong R,Appel SH

更新日期：1997-03-21 00:00:00