Repetitive seizures cause an increase in paired-pulse inhibition in the dentate gyrus.

Abstract:

:A paired-pulse stimulus protocol was used to measure angular bundle to dentate gyrus paired-pulse inhibition in rats before and after the occurrence of 36 or 72 seizures elicited from the contralateral CA3 region. The seizures showed progressive lengthening. There was a moderate increase in paired-pulse depression 1 h after 36 seizures and a further increase after 72 seizures. These data demonstrate that the same experimental protocol which produced a decrease in paired-pulse inhibition in the CA1 region caused the opposite effect in the dentate gyrus.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Stringer JL,Lothman EW

doi

10.1016/0304-3940(89)90017-7

subject

Has Abstract

pub_date

1989-10-23 00:00:00

pages

91-5

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(89)90017-7

journal_volume

105

pub_type

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