Abstract:
:The effect of dopamine on the 3',5'-cyclic adenosine monophosphate (cAMP) generating system of membrane particles of rat prostate gland was studied. Dopamine increased the concentration of cAMP in a dose-dependent manner. The selective D1 receptor inhibitor SCH 23390 caused a decrease in dopamine-elicited cAMP levels. Any effect of dopamine on prostatic cAMP concentration was abolished by the simultaneous addition to the incubation medium of SCH 23390 and of the D2 receptor blocking agent (-)-sulpiride. Also the D2 receptor agonist bromocriptine decreased cAMP levels. The present data indicate the existence, in the rat prostate gland, of two types of dopamine receptors mediating, respectively, the activation (D1 effect) and the inhibition (D2 effect) of adenylate cyclase activity.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Amenta D,Cavallotti C,Amenta Fdoi
10.1016/0304-3940(87)90608-2subject
Has Abstractpub_date
1987-06-01 00:00:00pages
66-70issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(87)90608-2journal_volume
77pub_type
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