Dopamine receptors mediating the stimulation and the inhibition of adenylate cyclase in rat prostate gland.

Abstract:

:The effect of dopamine on the 3',5'-cyclic adenosine monophosphate (cAMP) generating system of membrane particles of rat prostate gland was studied. Dopamine increased the concentration of cAMP in a dose-dependent manner. The selective D1 receptor inhibitor SCH 23390 caused a decrease in dopamine-elicited cAMP levels. Any effect of dopamine on prostatic cAMP concentration was abolished by the simultaneous addition to the incubation medium of SCH 23390 and of the D2 receptor blocking agent (-)-sulpiride. Also the D2 receptor agonist bromocriptine decreased cAMP levels. The present data indicate the existence, in the rat prostate gland, of two types of dopamine receptors mediating, respectively, the activation (D1 effect) and the inhibition (D2 effect) of adenylate cyclase activity.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Amenta D,Cavallotti C,Amenta F

doi

10.1016/0304-3940(87)90608-2

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

66-70

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(87)90608-2

journal_volume

77

pub_type

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