Nicotinamide inhibits inducible nitric oxide synthase mRNA in primary rat glial cells.

abstract：:Glucagon-like peptide-1 (GLP-1), an insulinotropic peptide secreted from enteroendocrine cells, has been known to have a neuroprotective effect. However, it is not fully understood the intracellular mediator of GLP-1 signaling in neuronal cells. In the present study, we examined the change in intracellular signaling o...

journal_title：Neuroscience letters

authors： Nakajima S,Numakawa T,Adachi N,Yoon HS,Odaka H,Ooshima Y,Kunugi H

更新日期：2016-03-11 00:00:00

abstract：:Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are characterized by T cell-mediated autoimmune inflammation of the central nervous system (CNS) leading to oligodendrocyte loss and demyelination accompanied by neuronal cell death. Neuronal TWIK-related acid-sensitive potass...

journal_title：Neuroscience letters

authors： Meuth SG,Kanyshkov T,Melzer N,Bittner S,Kieseier BC,Budde T,Wiendl H

更新日期：2008-12-03 00:00:00

abstract：:The effect of unilateral electrical stimulation of the posterior interposate nucleus of the cerebellum was examined on the activity of the nigro-striatal dopaminergic pathways on both sides of the brain in alpha-chloralose anaesthetized cats. Push-pull cannulae were inserted into both caudate nuclei and both substanti...

journal_title：Neuroscience letters

authors： Nieoullon A,Dusticier N

更新日期：1980-04-01 00:00:00

abstract：:Stress is a major risk factor in drug addiction development and relapse. Virtually all drugs of abuse act by increasing extracellular dopamine levels in the striatum. To gain an understanding of the interaction between stress and drug exposure, we studied the effects of concomitant chronic nicotine and chronic stress ...

journal_title：Neuroscience letters

authors： Salas R,De Biasi M

更新日期：2008-07-25 00:00:00

abstract：:Both substance P (SP)- and epinephrine-containing neurons in the rostral ventrolateral medulla have been thought to play a role in regulating vasomotor tone. The combination of retrograde transport of a fluorescent dye (Fast Blue) and immunofluorescent staining for SP- and phenylethanolamine-N-methyltransferase (PNMT)...

journal_title：Neuroscience letters

authors： Lorenz RG,Saper CB,Wong DL,Ciaranello RD,Loewy AD

更新日期：1985-04-19 00:00:00

abstract：:The density of hippocampal adenosine A1 receptors was measured in autopsy samples of six patients with dementia with either Alzheimer (three) or sclerosis type pathology (three) in hippocampus and six control patients. Kinetic parameters (Bmax and KD) were determined by means of quantitative autoradiography using [3H]...

journal_title：Neuroscience letters

authors： Deckert J,Abel F,Künig G,Hartmann J,Senitz D,Maier H,Ransmayr G,Riederer P

更新日期：1998-03-06 00:00:00

abstract：:Histamine H3 receptors (H3Rs) co-localize with dopamine (DA) D1 receptors (D1Rs) on striatal medium spiny neurons and functionally antagonize D1R-mediated responses. The intra-striatal administration of D1R agonists reduces DA release whereas D1R antagonists have the opposite effect. In this work, a microdialysis meth...

journal_title：Neuroscience letters

authors： Alfaro-Rodriguez A,Alonso-Spilsbury M,Arch-Tirado E,Gonzalez-Pina R,Arias-Montaño JA,Bueno-Nava A

更新日期：2013-09-27 00:00:00

abstract：:To investigate the actions of glucocorticoids (GCs) on astrocyte functions, interactions of dexamethasone and immediate early genes (IEGs) were studied in cell cultures of rat cerebral cortical astrocytes. Vasoactive intestinal peptide (VIP) induces rapid c-fos mRNA expression and morphological changes (stellation) in...

journal_title：Neuroscience letters

authors： Hisanaga K,Sagar SM,Koistinaho J,Hicks KJ,Sharp FR

更新日期：1993-06-25 00:00:00

abstract：:The autoradiographic [14C]2-deoxyglucose (2-DG) method was used to map the descending effects of midbrain reticular stimulation on the rat cervical spinal cord. The stimulation evoked consistently a defensive 'freezing' reaction as well as a large and highly localized increase in 2-DG uptake in the substantia gelatino...

journal_title：Neuroscience letters

authors： Gonzalez-Lima F

更新日期：1986-04-24 00:00:00

abstract：:Gap junctions between neurons contribute to synchronous neuronal firing and may play a role in the pathophysiology of epilepsy. We examined the expression of a number of gap junction subunits, including the neuronal gap junction forming protein connexin36 (Cx36), in the hippocampus at various time points following an ...

journal_title：Neuroscience letters

authors： McCracken CB,Roberts DC

更新日期：2006-09-11 00:00:00

abstract：:Loss of ganglion cells is a common and irreversible complication of hair cell loss in the cochlea. Gene transfer could potentially be used to prevent this neuronal degeneration and other pathologies in the cochlea. Human adenoviruses should provide a feasible gene transfer vehicle for transducing the quiescent cochlea...

journal_title：Neuroscience letters

authors： Raphael Y,Frisancho JC,Roessler BJ

更新日期：1996-03-29 00:00:00

abstract：:Ascending thalamo-telencephalic projection systems have been investigated in an urodele, Triturus alpestris, using the horseradish peroxidase technique. Two separate dorsal thalamic projections onto the telencephalon have been identified; one arises from the posterior dorsal thalamus and terminates in the ipsilateral ...

journal_title：Neuroscience letters

authors： Wicht H,Himstedt W

更新日期：1986-07-11 00:00:00

abstract：:This study compared the immediate and prolonged effects of acute bouts of active and passive leg cycling on the soleus H-reflex among 12 young healthy men. The soleus H-reflex was measured immediately before and then 10 and 30 min after 20 min of active, unloaded leg cycling, passively induced leg cycling, and quiet r...

journal_title：Neuroscience letters

authors： Motl RW,Knowles BD,Dishman RK

更新日期：2003-08-21 00:00:00

abstract：:A monoclonal antibody that reacts with a mid rod fragment of dystrophin was used to localize this protein in the central nervous system (CNS). Due to a low abundance of dystrophin in the CNS, an immunoperoxidase reaction amplified with a biotin-avidin system was used. All Purkinje cells in normal mice were dystrophin ...

journal_title：Neuroscience letters

authors： Huard J,Tremblay JP

更新日期：1992-03-16 00:00:00

abstract：:We describe the incidence of gamma-aminobutyric acid (GABA)ergic neurons after post-embedding immunocytochemistry on semithin sections of the claustrum, putamen and lateral, dorsal and medial cortical areas. Twelve percent of the neurons counted in the claustrum of 11 rabbits were GABAergic. This incidence was signifi...

journal_title：Neuroscience letters

authors： Gómez-Urquijo SM,Gutiérrez-Ibarluzea I,Bueno-López JL,Reblet C

更新日期：2000-03-24 00:00:00

abstract：:The binding and pharmacological characteristics of [125I]iodomelatonin binding sites in human fetal brain membrane preparations were determined. Membrane preparations of the whole brain revealed a equilibrium binding constant (Kd) of 17.5 pmol/l with a total number of binding sites (Bmax) at 0.8 fmol/mg protein. Among...

journal_title：Neuroscience letters

authors： Yuan H,Lu Y,Pang SF

更新日期：1991-09-16 00:00:00

abstract：:Five picrotoxinin analogues were examined on GABA-gated chloride channels of an identifiable cockroach (Periplaneta americana) motor neurone (Df). Substitution of the bridgehead hydroxyl at the C-6 position of the picrotoxinin molecule by a fluorine atom (fluoropicrotoxinin) had little effect, whereas acetylation of t...

journal_title：Neuroscience letters

authors： Anthony NM,Holyoke CW Jr,Sattelle DB

更新日期：1994-04-25 00:00:00

abstract：:Neural stem cell (NSC) transplantation has exhibited considerable therapeutic potential in spinal cord injury. However, most experiments in animals have been performed by injecting these cells directly into the injured spinal cord. A cardinal feature of NSCs is their exceptional migratory ability through the nervous s...

journal_title：Neuroscience letters

authors： Takeuchi H,Natsume A,Wakabayashi T,Aoshima C,Shimato S,Ito M,Ishii J,Maeda Y,Hara M,Kim SU,Yoshida J

更新日期：2007-10-16 00:00:00

abstract：:Neuronal cell cycle activation has been implicated in neurodegenerative diseases such as Alzheimer's disease, while the initiating mechanism of cell cycle activation remains to be determined. Interestingly, our previous studies have shown that cell cycle activation by c-Myc (Myc) leads to neuronal cell death which sug...

journal_title：Neuroscience letters

authors： Lee HP,Kudo W,Zhu X,Smith MA,Lee HG

更新日期：2011-11-14 00:00:00

abstract：:In vivo electrochemical techniques were employed to demonstrate that repeated treatment with classical antipsychotic drugs reduced basal dopamine (DA) release in the striatum and nucleus accumbens, whereas repeated treatment with atypical antipsychotics decreased DA release only in accumbens. Administration of apomorp...

journal_title：Neuroscience letters

authors： Blaha CD,Lane RF

更新日期：1987-07-22 00:00:00

abstract：:Somatosensory amplification refers to the tendency to experience benign and ambiguous somatic sensation as intense, noxious, and disturbing. The construct is helpful in assessing the perceptual style of a variety of somatizing conditions, but there is no human study clarifying the effects of neurological function on s...

journal_title：Neuroscience letters

authors： Nakao M,Barsky AJ,Nishikitani M,Yano E,Murata K

更新日期：2007-03-26 00:00:00

abstract：:Retinal progenitor cells (RPCs) are an excellent resource for retinal replacement therapy, because they show enormous potential to differentiate into retinal-specific cell types. While the differentiating influence of serum has long been appreciated, the effects of serum concentration on RPC differentiation into speci...

journal_title：Neuroscience letters

authors： Hu Y,Ji J,Xia J,Zhao P,Fan X,Wang Z,Zhou X,Luo M,Gu P

更新日期：2013-02-08 00:00:00

abstract：:Mitogen-activated protein kinases (MAPK) can be activated by opioids such as morphine via opioid receptor, and their activations have been observed in synaptic plasticity, learning, memory and addiction. Long-term exposure to morphine may induce physical dependence, manifested as somatic withdrawal symptoms such as di...

journal_title：Neuroscience letters

authors： Li T,Hou Y,Cao W,Yan CX,Chen T,Li SB

更新日期：2010-01-14 00:00:00

abstract：:The role of nitric oxide (NO) in N-methyl-D-aspartate (NMDA)-regulated release of 5-hydroxytryptamine (5-HT) in the frontal cortex and raphe nuclei of freely moving rats has been studied using microdialysis with dual probes, one in each region of the same animal. In order to do this the selective neuronal nitric oxide...

journal_title：Neuroscience letters

authors： Smith JC,Whitton PS

更新日期：2000-09-08 00:00:00

abstract：:The localization of luteinizing hormone-releasing hormone (LH-RH) has been studied in the human brain with the indirect immunofluorescence technique. LH-RH positive perikarya are scattered from the septo-preoptic region up to the retromammillary area and give rise to two main tracts ending in the infundibulum and the ...

journal_title：Neuroscience letters

authors： Barry J

更新日期：1976-12-01 00:00:00

abstract：:The current study investigated the time course of the affective processing bias in major depressive disorder (MDD) in a visual three-stimulus semantic oddball task using event-related potentials (ERPs). MDD patients showed decreased P1 latency over right posterior regions to negative relative to positive target stimul...

journal_title：Neuroscience letters

authors： Yang W,Zhu X,Wang X,Wu D,Yao S

更新日期：2011-01-10 00:00:00

abstract：:Fragile X syndrome (FXS), a disorder caused by a mutation in the FMR1 gene, is often associated with Attention Deficit Hyperactivity Disorder (ADHD). Common treatments for the hyperactivity often seen in ADHD involve the use of stimulants and α2-adrenergic agonists. The Fmr1 knockout (KO) mouse has been found to be a ...

journal_title：Neuroscience letters

authors： Wrenn CC,Heitzer AM,Roth AK,Nawrocki L,Valdovinos MG

更新日期：2015-01-12 00:00:00

abstract：:The purpose of this study was to identify the subcortical neural pathways which mediate adrenocortical responses following cortical stimulation. The frontal cortex was stimulated in intact rats and in animals with medial or lateral septal or preoptic lesions or with large or small anterior hypothalamic deafferentation...

journal_title：Neuroscience letters

authors： Feldman S,Conforti N

更新日期：1987-01-02 00:00:00

abstract：:A two-stage model of sustained neural activity in the prefrontal cortex is proposed in order to simulate feature binding and capacity limits in visual working memory. In the first stage, object features are stored in parallel network layers without explicit conjunctions. A second stage binds features into integrated o...

journal_title：Neuroscience letters

authors： Domijan D

更新日期：2003-10-23 00:00:00

abstract：:The synaptic relationships between gamma-aminobutyric acid (GABA)-immunoreactive and enkephalin-immunoreactive profiles in the cat spinal cord were examined using combined pre-embedding immunoperoxidase and post-embedding immunogold electron microscopic immunocytochemistry. Although colchicine was not used, enkephalin...

journal_title：Neuroscience letters

authors： Liu H,Llewellyn-Smith IJ,Pilowsky P,Basbaum AI

更新日期：1992-04-13 00:00:00