Abstract:
:Glucagon-like peptide-1 (GLP-1), an insulinotropic peptide secreted from enteroendocrine cells, has been known to have a neuroprotective effect. However, it is not fully understood the intracellular mediator of GLP-1 signaling in neuronal cells. In the present study, we examined the change in intracellular signaling of cortical neurons after GLP-1 application and luminal glucose stimulation in vitro and in vivo. GLP-1 receptor was highly expressed in cultured cortical neurons and brain tissues including the prefrontal cortex and hippocampus. The activation of GLP-1 receptor (5min) significantly decreased levels of phosphorylated extracellular signal-regulated kinase (pERK), which is involved in neuronal cell survival and death, in cultured cortical neurons. Oral glucose administration also rapidly reduced pERK levels in the prefrontal cortex, while intraperitoneal glucose injection did not show such an effect. Further, GLP-1 attenuated hydrogen peroxide-induced cell death and hyperactivity of ERK in cultured cortical neurons. It is possible that increased GLP-1 by luminal glucose stimulation affects cortical system including the maintenance of neuronal cell survival.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Nakajima S,Numakawa T,Adachi N,Yoon HS,Odaka H,Ooshima Y,Kunugi Hdoi
10.1016/j.neulet.2016.01.052subject
Has Abstractpub_date
2016-03-11 00:00:00pages
105-10eissn
0304-3940issn
1872-7972pii
S0304-3940(16)30051-9journal_volume
616pub_type
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