Abstract:
:Expression of vasoactive intestinal polypeptide (VIP) was studied in regenerating adult rat dorsal root ganglion (DRG) neurons in culture. VIP was not detected by radioimmunoassay in newly established cultures but increasing concentrations were observed between 2 and 4 days and VIP remained detectable for more than 2 weeks. Immunocytochemical staining revealed VIP-like immunoreactivity in virtually all neurons. Thus, VIP is expressed in regenerating DRG neurons in culture just as it is in vivo following axotomy. However, VIP concentrations in culture were the same whether nerve growth factor was present or not. Therefore, deprivation of retrogradely transported nerve growth factor is unlikely to explain VIP induction by axotomy in vivo.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Mulderry PK,Lindsay RMdoi
10.1016/0304-3940(90)90660-2subject
Has Abstractpub_date
1990-01-22 00:00:00pages
314-20issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(90)90660-2journal_volume
108pub_type
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