Abstract:
:Recently, we reported that a centrally acting non-narcotic antitussive (cough suppressant drug), tipepidine produces an antidepressant-like effect in the forced swimming test in rats. Because pharmacological properties of tipepidine apparently differ from those of typical antidepressants developed to date, we speculated that caramiphen, another centrally acting antitussive, has an antidepressant-like effect. That effect of caramiphen was studied in rats using the forced swimming test. Caramiphen at 20 and 40mg/kg i.p. significantly reduced immobility. At 40mg/kg i.p., it increased climbing behavior. Even at 40mg/kg, this drug had no effect on locomotor activity. Results suggest that a centrally acting antitussive possessing inhibition of GIRK channels has an antidepressant-like effect.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kawaura K,Miki R,Shima E,Honda S,Soeda F,Shirasaki T,Takahama Kdoi
10.1016/j.neulet.2010.07.003subject
Has Abstractpub_date
2010-09-13 00:00:00pages
188-90issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(10)00892-Xjournal_volume
481pub_type
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