Pathways to precision medicine in smoking cessation treatments.

abstract：:The cyclic AMP/protein kinase A signaling pathway is thought to be involved in neural differentiation of mesenchymal stem cells. In the present study, we examined the involvement of β-adrenoceptor signaling on the differentiation of mouse induced pluripotent stem (iPS) cells into neural progenitor cells. Mouse iPS cel...

journal_title：Neuroscience letters

authors： Ishizuka T,Goshima H,Ozawa A,Watanabe Y

更新日期：2012-09-06 00:00:00

abstract：:The cytokine interleukin-6 (IL-6) may be a contributing mediator of CNS injury in several neurological disorders. To investigate the role of IL-6 in memory-related disorders, we examined transgenic mice (GFAP-IL6) with cerebral overexpression of IL-6 using paired-pulse facilitation, paired-pulse inhibition, and long-t...

journal_title：Neuroscience letters

authors： Bellinger FP,Madamba SG,Campbell IL,Siggins GR

更新日期：1995-09-29 00:00:00

abstract：:Research indicates that threat-induced changes in standing balance are associated with shifts in attention focus. This study investigated whether distracting attention modifies threat-induced changes in standing balance. Twenty-five healthy young adults stood without (No Threat) and with (Threat) the possibility of re...

journal_title：Neuroscience letters

authors： Johnson KJ,Watson AM,Tokuno CD,Carpenter MG,Adkin AL

更新日期：2020-01-18 00:00:00

abstract：:In our horseradish peroxidase (HRP) study of the afferents to the medullary raphe nuclei in the cat, HRP uptake by damaged axons en route to the inferior olive (IO) was thought to be responsible for retrograde labelling of specific midbrain nuclei. To control for such indirect labelling, HRP was injected iontophoretic...

journal_title：Neuroscience letters

authors： Abols IA,Basbaum AI

更新日期：1979-07-01 00:00:00

abstract：:Surround inhibition (SI) is a neural mechanism to focus neuronal activity and facilitate selective motor execution (ME). The aim of the present study was to investigate whether SI is also generated during motor imagery (MI). Furthermore, we investigated whether the extent of SI during MI depends on the strength of SI ...

journal_title：Neuroscience letters

authors： Aoyama T,Kaneko F,Ohashi Y,Nagata H

更新日期：2016-08-26 00:00:00

abstract：:The results of several studies have suggested that local circuit neurons, or interneurons, of area CA1 of hippocampus use gamma-aminobutyric acid (GABA) as their neurotransmitter. However, when these cells were labelled by intracellular dye injection, and examined immunocytochemically with antisera raised against GABA...

journal_title：Neuroscience letters

authors： Scharfman HE,Kunkel DD,Schwartzkroin PA

更新日期：1989-01-02 00:00:00

abstract：:To determine whether mutations in the coding region of the alpha-synuclein gene are relevant in cases of multiple system atrophy (MSA), detailed nucleotide sequence analysis of the alpha-synuclein gene was performed using total RNA obtained from autopsied brain specimens of 11 pathologically confirmed cases of MSA. Th...

journal_title：Neuroscience letters

authors： Ozawa T,Takano H,Onodera O,Kobayashi H,Ikeuchi T,Koide R,Okuizumi K,Shimohata T,Wakabayashi K,Takahashi H,Tsuji S

更新日期：1999-07-30 00:00:00

abstract：:Despite extensive data addressing the regulation of the hypothalamo-pituitary-adrenal (HPA) axis in vertebrates, the neuroendocrine regulation of stress in birds remains incomplete. The paraventricular nucleus (PVN) contains the key neuropeptides, corticotropin releasing hormone (CRH) and arginine vasotocin (AVT), con...

journal_title：Neuroscience letters

authors： Nagarajan G,Kang SW,Kuenzel WJ

更新日期：2017-03-06 00:00:00

abstract：:This study was aimed to determine the effect of unilateral hippocampal inactivation on spatial memory retrieval in male and female Wistar rats. Subjects were chronically implanted with a stainless-steel cannula that enabled unilateral intrahippocampal injections of tetrodotoxin, a sodium channel blocker. Rats were tra...

journal_title：Neuroscience letters

authors： Cimadevilla JM,Arias JL

更新日期：2008-07-04 00:00:00

abstract：:Calcitonin gene-related peptide (CGRP) immunoreactive afferent nerves were seen intrarenally by prenatal day 16. They grow rapidly and CGRP positive nerves are observed at birth associated with the arterial and venous vascular tree, forming a rich plexus in the pelvic region and in the connective tissue located near t...

journal_title：Neuroscience letters

authors： Barajas L,Liu L,Nishiyama C

更新日期：1991-12-09 00:00:00

abstract：:Results from various genetic association studies of the lipoprotein lipase (LPL) S447X polymorphism and Alzheimer's disease (AD), range from a statistically significant negative association of clinically examined patients to a non-significant but consistent trend for under-representation of the X447 allele in neuropat...

journal_title：Neuroscience letters

authors： Fidani L,Compton D,Hardy J,Petersen RC,Tangalos E,Mirtsou V,Goulas A,De Vrieze FW

更新日期：2002-04-12 00:00:00

abstract：:Oestrogen influences both oxytocin mRNA and peptide immunoreactivity in the preoptic area and the rat oxytocin gene contains functional oestrogen response elements. However, using combinations of immunocytochemistry and in situ hybridization for oxytocin and oestrogen receptor, we found that preoptic oxytocin neurons ...

journal_title：Neuroscience letters

authors： Cruttwell CJ,Herbison AE,Bicknell RJ

更新日期：1995-11-17 00:00:00

abstract：:We have prepared dissociated cell cultures from adult rat optic nerve. After 48 h in culture cells of both fibroblastic and process-bearing morphology could be recognised. Using indirect immunofluroescence and cell-type specific markers it was possible to unambiguously identify astrocytes and oligodendrocytes in cultu...

journal_title：Neuroscience letters

authors： Kennedy PG,Lisak RP

更新日期：1980-03-01 00:00:00

abstract：:Two patients with Xp21 muscular dystrophy Becker type showed absence of dystrophin in muscle biopsy tested with 4 antibodies (polyclonal anti-60 kDa, monoclonal against the rod domain, the C-terminus and the N-terminus). DNA analysis did not detect any deletion in one patient and demonstrated deletion of exons 3-7 in ...

journal_title：Neuroscience letters

authors： Mongini T,Palmucci L,Doriguzzi C,Chiadoò-Piat L,Restagno G

更新日期：1992-11-23 00:00:00

abstract：:Abnormal alteration of brain function is a characteristic complication of hepatic encephalopathy in both acute and chronic liver failure. Previous studies suggest that the pathogenesis of hepatic encephalopathy involves chronic glial edema with subsequent alteration of glioneuronal communication, N-methyl-d-aspartate ...

journal_title：Neuroscience letters

authors： Ohara K,Aoyama M,Fujita M,Sobue K,Asai K

更新日期：2009-09-22 00:00:00

abstract：:Mounting evidence supports the association between a polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) and suicidal behaviour. Recently, a novel variant of the 5-HTTLPR L allele was identified. The previously unknown L(G) allele produced similar levels of gene expression to the S allele and mig...

journal_title：Neuroscience letters

authors： Hung CF,Lung FW,Chen CH,O'Nions E,Hung TH,Chong MY,Wu CK,Wen JK,Lin PY

更新日期：2011-10-31 00:00:00

abstract：:Recent studies suggest that mild hypothermia significantly alleviate damage following cerebral ischemia though the precise mechanism is poorly defined. In the present study, middle cerebral artery occlusion (MCAo) was induced in Sprague-Dawley (SD) rats for 1 h followed by varying periods of reperfusion. Cerebral infa...

journal_title：Neuroscience letters

authors： Prakasa Babu P,Yoshida Y,Su M,Segura M,Kawamura S,Yasui N

更新日期：2000-09-22 00:00:00

abstract：:Several studies have indicated that higher levels of childhood aerobic fitness is associated with superior cognitive function, and this association is disproportionately observed in tasks requiring greater top-down control. We designed the current study to clarify the relationship between childhood fitness and top-dow...

journal_title：Neuroscience letters

authors： Kamijo K,Takeda Y,Takai Y,Haramura M

更新日期：2016-10-06 00:00:00

abstract：:We have used the polyoma middle T oncogene to immortalize cells from rat embryo encephalon. Immunostaining experiments with monoclonal antibodies demonstrated that the cells of one of the obtained lines, named CEINGE CL3, are stained by anti-vimentin and anti-S100 antibodies, are not stained by anti-neurofilaments (NF...

journal_title：Neuroscience letters

authors： Russo T,Mogavero AR,Ammendola R,Mesuraca M,Fiore F,Fatatis A,Salvatore G,Cimino F

更新日期：1993-09-03 00:00:00

abstract：:In the present study, we demonstrate that the histopathologic features of myelin oligodendrocyte glycoprotein (MOG) peptide 35-55-induced experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice closely mirror the hallmarks of MS pathology. On the one hand, we depict a time-dependent transition from acute infla...

journal_title：Neuroscience letters

authors： Recks MS,Addicks K,Kuerten S

更新日期：2011-05-02 00:00:00

abstract：:Dietary flavonoids, including the citrus flavanone hesperetin, may have stimulatory effects on cytoprotective intracellular signalling pathways. In primary mouse cortical neurone cultures, but not SH-SY5Y human neuroblastoma cells or human primary dermal fibroblasts (Promocells), hesperetin (100-300nM, 15min) caused s...

journal_title：Neuroscience letters

authors： Rainey-Smith S,Schroetke LW,Bahia P,Fahmi A,Skilton R,Spencer JP,Rice-Evans C,Rattray M,Williams RJ

更新日期：2008-06-13 00:00:00

abstract：:Previous studies have demonstrated that both visual and proprioceptive feedback influence motor control. The relative contributions of these sensory modalities to the on-line computation of body position--that is, the body schema--remain unclear. We report a study designed to explore the roles of vision and propriocep...

journal_title：Neuroscience letters

authors： Shenton JT,Schwoebel J,Coslett HB

更新日期：2004-11-03 00:00:00

abstract：:Following sciatic nerve injury sympathetic invasion and basket formation is seen in dorsal root ganglia. We examined whether this phenomenon occurs in trigeminal ganglion (TG) following axotomy (IOAx) or chronic constriction injury to the infraorbital nerve (IOCCI). The IOCCI rats developed hyperresponsiveness to pinp...

journal_title：Neuroscience letters

authors： Benoliel R,Eliav E,Tal M

更新日期：2001-01-19 00:00:00

abstract：:Sapogenins from Anemarrhenae asphodeloides was reported to improve the learning and memory abilities. In this study, we investigated the effect of Timosaponin B-II(TB-II), a purified extract from A. asphodeloidesb on rat vascular dementia (VD) produced by transient (2h) middle cerebral artery occlusion. The learning a...

journal_title：Neuroscience letters

authors： Li TJ,Qiu Y,Yang PY,Rui YC,Chen WS

更新日期：2007-06-27 00:00:00

abstract：:Projections of neurones in Forel's field H (FFH) to the upper cervical cord and to the lower brainstem were demonstrated by retrograde labelling of the neurones with horseradish peroxidase (HRP). Systematic threshold mapping for evoking antidromic spikes of FFH neurones revealed that they projected to the neck motor n...

journal_title：Neuroscience letters

authors： Isa T,Itouji T,Sasaki S

更新日期：1988-07-19 00:00:00

abstract：:The vertebrate retina is known to mediate both visual and non-image-forming photic responses. With the use of statistical analyses of sections immunohistochemically labelled with a polyclonal antiserum against the activated form of protein CREB (p-CREB), a transcription factor which participates in some neural respons...

journal_title：Neuroscience letters

authors： Alvarez-López C,Cernuda-Cernuda R,Paniagua MA,Alvarez-Viejo M,Fernández-López A,García-Fernández JM

更新日期：2004-03-11 00:00:00

abstract：:Elevated introcular pressure (IOP)-induced retinal neuron ischemic death includes an early phase of necrosis and prolonged phase of apoptosis. We used this ischemic model to observe the changes of sortilin and p75(NTR) protein expressions in rat retina. The results of Western blot analysis showed the expression of p75...

journal_title：Neuroscience letters

authors： Wei Y,Wang N,Lu Q,Zhang N,Zheng D,Li J

更新日期：2007-12-18 00:00:00

abstract：:While past research suggests that ghrelin stimulates appetite through an action on hypothalamic signaling, recent evidence indicates that the peptide acts via mesotelencephalic dopamine neurons to alter appetitive motivation. In the present study, rats were trained to operantly respond for food on a progressive ratio ...

journal_title：Neuroscience letters

authors： Weinberg ZY,Nicholson ML,Currie PJ

更新日期：2011-07-20 00:00:00

abstract：:Preconditioning is a process where a preceding non-lethal form of stress activates a stress response that protects cells against an otherwise lethal form of stress. Preconditioning can be induced in various ways including short-term ischemia or spreading depression. Here we investigated the effect of 1 h repetitive sp...

journal_title：Neuroscience letters

authors： Schneeloch E,Wenkel S,Mies G,Paschen W

更新日期：2004-09-16 00:00:00

abstract：BACKGROUND:Chronic postoperative pain (CPOP) is a common clinical problem which might be related to central sensitization. It has been widely accepted that NMDA (N-methyl-D-aspartate) receptors are among the triggers of central sensitization. Ketamine is a non-competitive NMDA receptor antagonist that is widely used in...

journal_title：Neuroscience letters

authors： Shen Y,Xu L,Liu M,Lei Y,Gu X,Ma Z

更新日期：2016-03-11 00:00:00