Abstract:
:Preconditioning is a process where a preceding non-lethal form of stress activates a stress response that protects cells against an otherwise lethal form of stress. Preconditioning can be induced in various ways including short-term ischemia or spreading depression. Here we investigated the effect of 1 h repetitive spreading depression on the unfolded protein response (UPR), a stress response activated under conditions associated with endoplasmic reticulum (ER) dysfunction. Spreading depression induced processing of xbp1 mRNA, indicative of an activation of UPR. Processing of xbp1 was paralleled by a rise in grp78 mRNA levels resulting from an activation of a signal transduction pathway that depends on protein synthesis. Preconditioning-induced activation of UPR may preserve ER functioning under pathological conditions interfering with ER functions.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Schneeloch E,Wenkel S,Mies G,Paschen Wdoi
10.1016/j.neulet.2004.06.061keywords:
subject
Has Abstractpub_date
2004-09-16 00:00:00pages
37-40issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(04)00809-2journal_volume
368pub_type
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