Abstract:
:Using the novel substituted benzamide drug [3H]raclopride in combination with in vitro receptor autoradiography, the distribution of dopamine D-2 receptors was studied in the monkey brain. Highest densities of D-2 receptors are present in dopamine-rich areas and the distribution shows the following rank order: caudatus and putamen greater than nucleus accumbens greater than olfactory tubercle greater than substantia nigra (pars compacta) greater than insular cortex greater than piriform and entorhinal cortex greater than substantia nigra (pars reticulata). In all of these areas [3H]raclopride binding was blocked by dopamine (1 microM) and by D-2 receptor antagonists such as (+)-butaclamol, eticlopride and raclopride, while the D-1 receptor antagonist SCH 23390 (1 microM) reduced [3H]raclopride binding by 15-20% in some restricted parts of the caudatus and putamen exclusively.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Köhler C,Radesäter ACdoi
10.1016/0304-3940(86)90170-9subject
Has Abstractpub_date
1986-05-06 00:00:00pages
85-90issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(86)90170-9journal_volume
66pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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更新日期:2009-02-27 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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更新日期:1981-09-25 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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更新日期:1981-03-10 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2012-12-07 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2011-07-12 00:00:00
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journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1994-01-03 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1986-10-30 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2008-10-31 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2006-01-23 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2008-04-18 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1996-07-05 00:00:00