Expression of glycine and other amino acid receptors by rat spinal cord mRNA in Xenopus oocytes.

Abstract:

:Xenopus oocytes were injected with mRNA from adult or neonatal rat spinal cord, or from adult cerebral cortex, and examined electrophysiologically to measure currents elicited by various receptor agonists. The mRNAs induced the oocytes to acquire similar types of amino acid receptors, albeit with different potencies. In oocytes injected with adult cord mRNA the responses to kainate and gamma-aminobutyrate were much smaller, whilst the currents elicited by glycine and beta-alanine were markedly larger, than those in oocytes injected with cortex mRNA. For these receptors, the expressional potency of neonatal spinal cord mRNA is similar to that of the adult cord mRNA, except for a lower sensitivity to beta-alanine.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Akagi H,Miledi R

doi

10.1016/0304-3940(88)90668-4

subject

Has Abstract

pub_date

1988-12-19 00:00:00

pages

262-8

issue

1-3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(88)90668-4

journal_volume

95

pub_type

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