Abstract:
:We examined the distribution of ferric ion-ferrocyanide stain (a marker for excitable regions of myelinated fibers) in the lead-induced demyelinating neuropathy of the rat. By electron microscopy, we found that paranodal degeneration resulted in spreading of the reaction product from nodal to internodal axolemma. During repair, nodal-like stained areas formed at the contact zones between preremyelinating Schwann cells. These data suggest that the location and extent of excitable axonal regions are influenced by axoglial relationships. Additionally, some fibers displayed staining at paranodal axolemma adjacent to demyelinated segments, suggesting it might be an alternative site for impulse generation in demyelinated fibers.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Coria F,Silos I,Fernandez R,Monton F,Lafarga Mdoi
10.1016/0304-3940(85)90081-3subject
Has Abstractpub_date
1985-08-05 00:00:00pages
359-64issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(85)90081-3journal_volume
58pub_type
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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