Remacemide hydrochloride reduces cortical lesion volume following brain trauma in the rat.

abstract：:Using in vivo voltammetric detection of nitric oxide (NO) a previous study demonstrated an increased NO release at the lumbar dorsal horn level of the spinal cord by peripheral inflammatory processes in decerebrated-spinalized rats. This study concerns the effects of acute peripheral stimulations. Gentle non-noxious o...

journal_title：Neuroscience letters

authors： Rivot JP,Montagne-Clavel J,Besson JM

更新日期：2002-03-01 00:00:00

abstract：:To identify choline acetyltransferase (ChAT) transcript(s) in human foetal brain we used the reverse polymerase chain reaction including different couples of oligonucleotide primers. The analysis indicated the presence of a new choline acetyltransferase transcript containing at its 5' end an untranslated exon (E1A) of...

journal_title：Neuroscience letters

authors： Schmitt M,Garnier JM,Simoni P,Quirin-Stricker C

更新日期：1994-09-12 00:00:00

abstract：:Spinal muscular atrophy (SMA), a primarily childhood form of motor neuron disease, is caused by reduced levels of a single, ubiquitously expressed protein: the survival motor neuron (SMN) protein. Low levels of SMN cause motor neuron degeneration but recent reports describe effects of low SMN levels in multiple tissue...

journal_title：Neuroscience letters

authors： Somers E,Riessland M,Schreml J,Wirth B,Gillingwater TH,Parson SH

更新日期：2013-06-07 00:00:00

abstract：:The myelin oligodendrocyte glycoprotein (MOG) is a minor CNS myelin-specific protein that is an important candidate autoantigen in multiple sclerosis. We now report that MOG mRNA transcripts are present in the peripheral nervous system of rodents and primates at levels approximately ten-fold lower than in brain as dem...

journal_title：Neuroscience letters

authors： Pagany M,Jagodic M,Schubart A,Pham-Dinh D,Bachelin C,Baron van Evercooren A,Lachapelle F,Olsson T,Linington C

更新日期：2003-10-30 00:00:00

abstract：:Schisandra chinensis is commonly used for food and as a traditional remedy for the treatment of neuronal disorders. However, it is unclear which component of S. chinensis is responsible for its neuropharmacological effects. To answer this question, we isolated α-iso-cubebene, a dibenzocyclooctadiene lignin, from S. ch...

journal_title：Neuroscience letters

authors： Park SY,Park SJ,Park NJ,Joo WH,Lee SJ,Choi YW

更新日期：2013-10-25 00:00:00

abstract：:Previous magnetoencephalography (MEG) studies of sleep spindles have identified a complex and widespread distribution in parietal and frontal cortices by fitting a dipolar model to the data. In this study, we used a whole-head 151-channel MEG system with simultaneous electroencephalography (EEG) recording in eight nor...

journal_title：Neuroscience letters

authors： Ishii R,Dziewas R,Chau W,Sörös P,Okamoto H,Gunji A,Pantev C

更新日期：2003-04-03 00:00:00

abstract：:Serotonin (5-HT) has been implicated in the regulation of circadian rhythms through its actions on the suprachiasmatic nucleus (SCN). Recent data suggests that, along with excitatory amino acids, serotonin may be important in the neural pathway that mediates the transmission of photic information to the circadian syst...

journal_title：Neuroscience letters

authors： Moyer RW,Kennaway DJ

更新日期：1999-08-27 00:00:00

abstract：:It is debated whether non-affected relatives of patients with affective disorders share a specific brain structure endophenotype. Aim of this work is to explore the medial temporal morphology in affected and non-affected members of a family with mood disorders. Hippocampi and amygdalae were manually traced from the 3D...

journal_title：Neuroscience letters

authors： Boccardi M,Almici M,Bresciani L,Caroli A,Bonetti M,Monchieri S,Gennarelli M,Frisoni GB

更新日期：2010-01-04 00:00:00

abstract：:Substance P immunoreactivity has been detected in varicosities around cell bodies of the nucleus dorsalis (Clarke's column) of the human spinal cord. This immunostaining probably represents neuropeptide immunoreactivity either in the nerve terminals of spinal interneurone, descending projections or in the primary dors...

journal_title：Neuroscience letters

authors： Pioro EP,Hughes JT,Cuello AC

更新日期：1984-09-28 00:00:00

abstract：:Electrophysiological and anatomic studies suggest that the amygdala regulates gastrointestinal motility and gastric acid secretion via projections to the dorsal vagal complex. The topography of these projections is poorly understood. Here, these projections were investigated by injecting anterograde tracer, Phaseolus ...

journal_title：Neuroscience letters

authors： Liubashina O,Jolkkonen E,Pitkänen A

更新日期：2000-09-15 00:00:00

abstract：:Benzodiazepine (Bzd) agonist, diazepam (Dzp) and inverse agonist methyl beta-carboline-3-carboxylate (beta-CCM); acetylcholinesterase inhibitor, physostigmine (Physo) and muscarinic antagonist, scopolamine (Scopo), were investigated for their mnesic effect in a passive avoidance (PA) task in rats. Impairments were obs...

journal_title：Neuroscience letters

authors： Anglade F,Bizot JC,Dodd RH,Baudoin C,Chapouthier G

更新日期：1994-12-05 00:00:00

abstract：:Neuropeptides orexin-A and -B are related to the regulation of sleep/wakefulness and feeding behaviors. Recently, the peptides have also been shown to yield antinociceptive effects in various pain models. However, it is not clear whether orexins are involved in forms of synaptic plasticity, such as long-term potentiat...

journal_title：Neuroscience letters

authors： Park KB,Weon H

更新日期：2017-11-01 00:00:00

abstract：:Glutamatergic system, the main stimulating system of the brain, plays an important role in the pathogenesis of schizophrenia. Hippocampus, a structure crucial for memory and cognitive functions and rich in glutamatergic neurons, is a natural object of interest in studies on psychoses. Sarcosine, a glycine transporter ...

journal_title：Neuroscience letters

authors： Strzelecki D,Podgórski M,Kałużyńska O,Gawlik-Kotelnicka O,Stefańczyk L,Kotlicka-Antczak M,Gmitrowicz A,Grzelak P

更新日期：2015-10-08 00:00:00

abstract：:As a variant of peptide conantokin-T (con-T), con-T[M8Q] is derived from the venom of Conus tulipa. Our previous study has demonstrated that con-T[M8Q] selectively targets N-methyl-d-aspartate receptor (NMDAR) NR2B subunit. In the present study, we determined the effects of con-T[M8Q] on the expression and development...

journal_title：Neuroscience letters

authors： Ren B,Zhou Z,Liu Z,Li B,Ou J,Dai Q

更新日期：2015-06-15 00:00:00

abstract：:IL-1beta is a proinflammatory cytokine that contributes to psychological stress responses and has been implicated in various psychiatric disorders most notably depression. Preclinical studies also demonstrate that IL-1beta modulates anxiety- and fear-related behaviors, although these findings are difficult to assess b...

journal_title：Neuroscience letters

authors： Koo JW,Duman RS

更新日期：2009-05-29 00:00:00

abstract：:Huntington disease is an uncommon autosomal dominant neurodegenerative disorder caused by expanded polyglutamine repeats in the huntingtin protein. The proximate mechanisms responsible for neurodegeneration are unknown. Copper ions may play a role in Huntington disease by promoting oligomerization of expanded polyglut...

journal_title：Neuroscience letters

authors： Tallaksen-Greene SJ,Janiszewska A,Benton K,Hou G,Dick R,Brewer GJ,Albin RL

更新日期：2009-03-06 00:00:00

abstract：:Neuromuscular electrical stimulation (NMES) increases the excitability of corticospinal (CS) pathways by altering circuits in motor cortex (M1). How NMES affects circuits interposed between the ascending afferent volley and descending CS pathways is not known. Presently, we hypothesized that short-latency afferent inh...

journal_title：Neuroscience letters

authors： Mang CS,Bergquist AJ,Roshko SM,Collins DF

更新日期：2012-10-31 00:00:00

abstract：:Restoration of autophagy represents a potential therapeutic target for neurodegenerative disorders, but factors that regulate autophagic flux are largely unknown. When deprived of trophic factors, cultured Purkinje neurons die by an autophagy associated cell death mechanism. The accumulation of autophagic vesicles and...

journal_title：Neuroscience letters

authors： Bains M,Zaegel V,Mize-Berge J,Heidenreich KA

更新日期：2011-01-20 00:00:00

abstract：:A culture of peripheral nerve cells enriched in Schwann cells was obtained from sciatic nerve in normal and demyelinating trembler mutant. These cells incorporated and metabolized a non-physiological trans fatty acid (elaidic aid) as well as the physiological cis isomer (oleic acid). Both acids were incorporated simil...

journal_title：Neuroscience letters

authors： Bourre JM,Boutry JM,Masson M,Hauw JJ

更新日期：1982-05-28 00:00:00

abstract：:We looked for an interaction between etifoxine and the neurosteroid allopregnanolone at central gamma-aminobutyric acid (GABA(A)) receptors. Etifoxine (2 microM) did not affect the affinity of allopregnanolone (IC(50)=108 nM) for its site in preparations of Sprague-Dawley rat cerebral cortex membranes, as determined b...

journal_title：Neuroscience letters

authors： Verleye M,Schlichter R,Neliat G,Pansart Y,Gillardin JM

更新日期：2001-04-06 00:00:00

abstract：:The stability of neurotensin (NT) and a potent, long lasting analogue, [D-Trp11]-NT, to rat brain peptidases was compared by incubating the peptides with subcellular fractions (synaptosomes, synaptic membranes) and a purified endopeptidase from rat brain. Degradation of the peptides with time was followed by high perf...

journal_title：Neuroscience letters

authors： McDermott JR,Gibson AM,Biggins JA

更新日期：1986-12-03 00:00:00

abstract：:Parkinson's disease (PD) may be initiated or precipitated by endogenous toxins with a structure similar to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in genetically-predisposed individuals. Nicotinamide N-methyltransferase (NNMT) catalyzes N-methylation of nicotinamide and other pyridines to form pyridinium ions. Th...

journal_title：Neuroscience letters

authors： Aoyama K,Matsubara K,Kondo M,Murakawa Y,Suno M,Yamashita K,Yamaguchi S,Kobayashi S

更新日期：2001-01-26 00:00:00

abstract：:We have previously used antisense oligodeoxynucleotides (ODN) to the cloned delta opioid receptor (DOR) to inhibit the antinociceptive response to spinally administered delta opioid receptor selective agonists in mice. Here we have examined the effect of DOR antisense ODN treatment on the level of DOR expressed in NG ...

journal_title：Neuroscience letters

authors： Lai J,Riedl M,Stone LS,Arvidsson U,Bilsky EJ,Wilcox GL,Elde R,Porreca F

更新日期：1996-08-09 00:00:00

abstract：:Parkin gene mutations are by far the most common mutations in both familial Parkinson's disease (PD) and sporadic PD. Approximately, 50% of parkin mutations is exon dosage mutations (i.e., deletions and duplications of entire exons). Here, we first established a MLPA assay for quick detection of parkin exon rearrangem...

journal_title：Neuroscience letters

authors： Guo JF,Dong XL,Xu Q,Li N,Yan XX,Xia K,Tang BS

更新日期：2015-09-14 00:00:00

abstract：:Localization of 5-hydroxytryptamine immunoreactivity was studied in the rat coeliac-superior mesenteric ganglion complex and in the porcine superior and inferior mesenteric ganglia by the indirect immunofluorescence technique. In normal rats, only 5-hydroxytryptamine immunoreactive SIF cells were seen in the coeliac-s...

journal_title：Neuroscience letters

authors： Karhula T,Soinila S,Lakomy M,Majewski M,Kaleczyk J,Häppölä O

更新日期：1995-07-14 00:00:00

abstract：:Present study was conducted to identify the efferents mediating the vasosensory reflexes evoked by intra-arterial (i.a.) injection of Mesobuthus tamulus (BT; 1mg/kg) venom in the distal segment of femoral artery. Blood pressure (BP), electrocardiogram (ECG) and respiratory movements were recorded for 60 min after the ...

journal_title：Neuroscience letters

authors： Singh SK,Deshpande SB

更新日期：2009-10-30 00:00:00

abstract：:Reciprocal Ia inhibition from ankle flexors to extensors was studied in five patients with spasticity due to incomplete traumatic spinal cord lesions. Nine healthy subjects were tested as controls. Excitability of the soleus motoneuron pool was estimated by H-reflex testing in the resting state. Ia inhibition was acti...

journal_title：Neuroscience letters

authors： Boorman G,Hulliger M,Lee RG,Tako K,Tanaka R

更新日期：1991-06-10 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of neurological disability across all ages, but the elderly are particularly vulnerable and have a worse prognosis than younger individuals. To advance the understanding of long-term pathogenesis induced by TBI in the elderly, aged mice (21 -- 24 months) were given a contr...

journal_title：Neuroscience letters

authors： Onyszchuk G,LeVine SM,Brooks WM,Berman NE

更新日期：2009-03-13 00:00:00

abstract：:We combined fluorescent tracing with immunohistochemistry to examine nitric oxide synthase (NOS) containing neurons in the rat ventral lateral geniculate nucleus (vLGN). NOS immunopositive neurons in vLGN had a similar appearance to previously described NADPH-d positive neurons. The majority (96%) of the NOS immunopos...

journal_title：Neuroscience letters

authors： Meng XW,Ohara PT,Ralston HJ 3rd

更新日期：1998-11-06 00:00:00

abstract：:The neurotoxicant MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), administered to male or female mice, decreased striatal dopamine content and increased the levels of the astrocyte intermediate filament protein, glial fibrillary acidic protein (GFAP). The rise in GFAP was evident as early as two days following th...

journal_title：Neuroscience letters

authors： Reinhard JF Jr,Miller DB,O'Callaghan JP

更新日期：1988-12-19 00:00:00