Immunohistochemical localization of serotonin receptors in the rat suprachiasmatic nucleus.

Abstract:

:Serotonin (5-HT) has been implicated in the regulation of circadian rhythms through its actions on the suprachiasmatic nucleus (SCN). Recent data suggests that, along with excitatory amino acids, serotonin may be important in the neural pathway that mediates the transmission of photic information to the circadian system. The present study uses immunohistochemistry to examine the presence of three different 5-HT receptor subtypes in the suprachiasmatic nucleus (5-HT2a, 5-HT2c and 5-HT7) in male albino Wistar rats. In the SCN, there was a considerable amount of 5-HT2c-receptor-like immunoreactivity, a lesser amount of 5-HT2a positive fibres and no staining with antiserum against the 5-HT7 receptor subtype. These results are compatible with previous pharmacological evidence obtained in our laboratory showing that serotonin acting through the 5-HT2c receptor subtype may be important in the phase shifting effects of light on the circadian system.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Moyer RW,Kennaway DJ

doi

10.1016/s0304-3940(99)00536-4

keywords:

subject

Has Abstract

pub_date

1999-08-27 00:00:00

pages

147-50

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394099005364

journal_volume

271

pub_type

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