Abstract:
:The Flinders Sensitive Line rats showed an increased immobility response by 104% (P<0.01) in the forced swim test with respect to the Flinders Resistant Line rats (control). The Flinders Sensitive Line rats also had an increase of [(125)I]galanin (porcine) binding in the dorsal raphe (55+/-3.3 fmol/mg protein) with respect to the Flinders Resistant Line rats (38+/-3.6 fmol/mg protein) (42%, P<0.05) without changes in galanin receptor affinity and with a significant reduction (32.3%, P<0.05) of galanin-like immunoreactivity in the dorsal raphe. The results indicate that enhancement of galanin receptor function in the dorsal raphe rich in 5-HT neurons could be a mechanism involved in the production of depressive-like activity in this animal model of depression.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Bellido I,Díaz-Cabiale Z,Jiménez-Vasquez PA,Andbjer B,Mathé AA,Fuxe Kdoi
10.1016/s0304-3940(01)02446-6keywords:
subject
Has Abstractpub_date
2002-01-11 00:00:00pages
101-5issue
2eissn
0304-3940issn
1872-7972pii
S0304394001024466journal_volume
317pub_type
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