Abstract：
:Mounting evidence suggests a chronic pro-inflammatory state in individuals with bipolar disorder (BD). Stress exposure is known to exacerbate several inflammatory conditions as well as psychiatric disorders. Here, we analyzed plasma levels of pro-inflammatory cytokines and their soluble receptors to realistic acute psychosocial stress challenge in BD. Thirteen euthymic type 1 BD patients and 15 matched controls underwent the Trier Social Stress Test protocol (TSST). Blood samples were collected before and after TSST and plasma cytokines interleukin IL-2, IL-6, IL-33, and tumor necrosis factor alpha (TNF-α) were measured. In addition TNF-α soluble receptors TNFR1 and TNFR2, and IL-33 soluble receptor sST2 were assessed. Increased IL-33 and reduced sST2 levels were observed in BD subjects as compared to controls, independently of stress exposure. Following TSST, there were higher levels of IL-2 and reduced levels of sTNFR1 in both groups. However, the magnitude change for both cytokines was found higher in controls than BD subjects. Our data suggest that BD patients have differential stress reactivity as compared to controls, possibly related to an immunologic imbalance and failure of regulatory mechanisms.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Wieck A,Grassi-Oliveira R,do Prado CH,Rizzo LB,de Oliveira AS,Kommers-Molina J,Viola TW,Marciano Vieira EL,Teixeira AL,Bauer MEdoi
10.1016/j.neulet.2014.07.040subject
Has Abstractpub_date
2014-09-19 00:00:00pages
17-21eissn
0304-3940issn
1872-7972pii
S0304-3940(14)00621-1journal_volume
580pub_type
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