Abstract:
:Basal forebrain (BF) lesions induced by ibotenic acid produced increases in the Bmax and Kd values of [3H]QNB binding sites in the frontal cortex, parietal cortex, and hippocampus. Twenty-eight-day successive administration of propentofylline (10 and 25 mg/kg, p.o.) significantly reduced the Kd values of [3H]QNB binding sites, to the levels of those in a sham group, in a dose-dependent manner. Moreover, propentofylline (25 mg/kg, p.o.) significantly reduced the Bmax value of [3H]QNB binding sites compared with that in a vehicle-treated BF-lesioned group. These results suggest that successive administration of propentofylline ameliorates changes in muscarinic cholinergic receptors through improving presynaptic cholinergic dysfunction.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Fuji K,Hiramatsu M,Hayashi S,Kameyama T,Nabeshima Tdoi
10.1016/0304-3940(93)90117-4subject
Has Abstractpub_date
1993-02-05 00:00:00pages
99-102issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(93)90117-4journal_volume
150pub_type
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