Transthyretin binds amyloid beta peptides, Abeta1-42 and Abeta1-40 to form complex in the autopsied human kidney - possible role of transthyretin for abeta sequestration.

abstract：:Intracellular recording techniques were used to monitor the evoked responses in hippocampal CA1 pyramidal cells following focal stimulation of the proximally and distally located apical dendritic synapses. The local anaesthetic, QX-314, when injected into individual cells, caused a complete time-dependent blockade of ...

journal_title：Neuroscience letters

authors： Colling SB,Wheal HV

更新日期：1994-05-19 00:00:00

abstract：:Since the mRNA level of Fyn, a neurodevelopmental molecule, expression had been reported to be increased in postmortem schizophrenic prefrontal cortex and showed a strong correlation with age of disease onset, we investigated whether the three polymorphisms of the Fyn gene on genomic DNA (-93A/G, IVS10+37T/C and Ex12+...

journal_title：Neuroscience letters

authors： Ohnuma T,Shibata N,Matsubara Y,Sato S,Yamashina M,Arai H

更新日期：2003-05-29 00:00:00

abstract：:In this report the effects of phencyclidine (PCP) on physiologic variables, local cerebral blood flow (LCBF), and on hippocampal cell damage were measured in a rat model of forebrain ischemia (2-vessel occlusion and hypotension). Ischemia was induced for 10 min. LCBF was determined after 2 min of recirculation, using ...

journal_title：Neuroscience letters

authors： Sauer D,Nuglisch J,Rossberg C,Mennel HD,Beck T,Bielenberg GW,Krieglstein J

更新日期：1988-09-12 00:00:00

abstract：:This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) receptor antagonist, in mice and rats to confirm the involvement of 5-hydroxytryptamine (5-HT) neurons in PCP actions in comparison with 5-methoxy-N,N-dimethyltryptamine (5-MeO...

journal_title：Neuroscience letters

authors： Nabeshima T,Ishikawa K,Yamaguchi K,Furukawa H,Kameyama T

更新日期：1987-05-19 00:00:00

abstract：:Sex differences are often reported in spatial abilities. However, some studies show conflicting results, which can be ascribed to the complexity of the variables involved in the visuo-spatial domain. Until a few years ago, it was widely accepted that men outperformed women on almost all spatial tasks. However, recentl...

journal_title：Neuroscience letters

authors： Piccardi L,Iaria G,Ricci M,Bianchini F,Zompanti L,Guariglia C

更新日期：2008-02-20 00:00:00

abstract：:The acute thermoregulatory effect of microinjection of capsaicin into the nucleus raphe dorsalis (NRD) has been studied in anesthetised rats. Application of capsaicin (20 micrograms) into the NRD increased the tail skin temperature and decreased the body temperature. In animals that had previously been treated with ca...

journal_title：Neuroscience letters

authors： Hajós M,Hjorth S,Carlsson A

更新日期：1987-03-31 00:00:00

abstract：:In order to characterise primary central nervous system lymphomas (PCNSL) and to evaluate if 1H spectroscopy improves the preoperative differential diagnosis of PCNSL and glioma, seven immunocompetent patients with PCNSL and 21 patients with glioma were examined using single voxel, short echo time magnetic resonance s...

journal_title：Neuroscience letters

authors： Harting I,Hartmann M,Jost G,Sommer C,Ahmadi R,Heiland S,Sartor K

更新日期：2003-05-22 00:00:00

abstract：:Treatment with acamprosate, a compound used for relapse prevention treatment of alcoholism, was recently shown to be associated with increased plasma concentration of beta-endorphin in rats selectively bred for high alcohol preference. The aim of our study was to prove this result in a comparative clinical study with ...

journal_title：Neuroscience letters

authors： Kiefer F,Jahn H,Otte C,Nakovics H,Wiedemann K

更新日期：2006-08-14 00:00:00

abstract：:Adenosine has been implicated in the regulation of rapid eye movement sleep (REMS). In an attempt to understand the mechanism of production of adenosine in relation to REMS it was hypothesized that should it be involved in REMS, the latter's deprivation is likely to affect its synthetic machinery. Hence, male albino r...

journal_title：Neuroscience letters

authors： Thakkar M,Mallick BN

更新日期：1996-03-15 00:00:00

abstract：:To identify choline acetyltransferase (ChAT) transcript(s) in human foetal brain we used the reverse polymerase chain reaction including different couples of oligonucleotide primers. The analysis indicated the presence of a new choline acetyltransferase transcript containing at its 5' end an untranslated exon (E1A) of...

journal_title：Neuroscience letters

authors： Schmitt M,Garnier JM,Simoni P,Quirin-Stricker C

更新日期：1994-09-12 00:00:00

abstract：:8-OH-DPAT is a 5-HT(1A/7) receptor agonist that enhances behavioral recovery after traumatic brain injury (TBI). This study is a first attempt to decipher whether the benefits induced by 8-OH-DPAT after TBI are mediated by 5-HT(1A) or 5-HT(7) receptors. A single i.p. injection of 8-OH-DPAT (0.5 mg/kg) alone or co-admi...

journal_title：Neuroscience letters

authors： Yelleswarapu NK,Tay JK,Fryer WM,Shah MA,Garcia AN,Cheng JP,Kline AE

更新日期：2012-05-02 00:00:00

abstract：:Pineal concentrations of 5-methoxytryptamine, 5-methoxytryptophol, 5-methoxyindole acetic acid and melatonin were determined using high performance liquid chromatography following administration of different monoamine oxidase (MAO) inhibitors (clorgyline, pargyline and deprenyl) to golden hamsters. Plasma concentratio...

journal_title：Neuroscience letters

authors： Raynaud F,Pévet P

更新日期：1991-02-25 00:00:00

abstract：:The localisation of transforming growth factor-beta-2 (TGF-beta 2) in skeletal muscles was investigated with immunohistochemistry. In neonates, TGF-beta 2 was distributed throughout the muscle fibres but as the fibres matured TGF-beta 2 became restricted to the circumference of a small subpopulation of nuclei. These n...

journal_title：Neuroscience letters

authors： McLennan IS,Koishi K

更新日期：1994-08-15 00:00:00

abstract：:Histamine H3 receptors (H3Rs) co-localize with dopamine (DA) D1 receptors (D1Rs) on striatal medium spiny neurons and functionally antagonize D1R-mediated responses. The intra-striatal administration of D1R agonists reduces DA release whereas D1R antagonists have the opposite effect. In this work, a microdialysis meth...

journal_title：Neuroscience letters

authors： Alfaro-Rodriguez A,Alonso-Spilsbury M,Arch-Tirado E,Gonzalez-Pina R,Arias-Montaño JA,Bueno-Nava A

更新日期：2013-09-27 00:00:00

abstract：:Transforming growth factor (TGF)-β stimulates release of interleukin (IL)-6, which is recognized to function as both a pro- and anti- inflammatory cytokine in the central nervous system, from astrocytes. It is generally recognized that effects of TGF-β are mediated through Smad-independent as well as Smad-dependent pa...

journal_title：Neuroscience letters

authors： Tanabe K,Kojima A,Tachi J,Nakashima D,Kozawa O,Iida H

更新日期：2019-03-23 00:00:00

abstract：:Estrogen-dependent enhancement of glucoprivic-induced luteinizing hormone (LH) suppression is hypothesized to be due to increased estrogen receptor alpha (ERalpha)-immunoreactive (ir) cells in specific brain nuclei in a manner similar to fasting. ERalpha expression in various brain areas was determined in ovariectomiz...

journal_title：Neuroscience letters

authors： Reyes BA,Estacio MA,I'Anson H,Tsukamura H,Maeda KI

更新日期：2001-02-16 00:00:00

abstract：:The involvement of L-type calcium channels in heterosynaptic long-term depression (LTD) of the stratum radiatum input to area CA1 was studied in rat hippocampal slices. LTD of the radiatum field excitatory postsynaptic potential (EPSP) and population spike, produced by tetanization of the alveus in the presence of pic...

journal_title：Neuroscience letters

authors： Wickens JR,Abraham WC

更新日期：1991-09-02 00:00:00

abstract：:Opioid kappa-agonists had much more potent inhibitory effects on the high K+-evoked Met-enkephalin release from rat brain slices than did the mu- or delta-agonists. The opioid kappa- antagonist, MR2266 enhanced the evoked release of Met-enkephalin to a greater extent than did mu- or delta-antagonists in vitro and had ...

journal_title：Neuroscience letters

authors： Ueda H,Fukushima N,Ge M,Takagi H,Satoh M

更新日期：1987-10-29 00:00:00

abstract：:The transcriptional regulation of the gene encoding α-synuclein (SNCA) is thought to play a critical role in the pathogenesis of Parkinson's disease (PD), as common genetic variability in this gene is associated with an elevated risk of developing PD. However, the relevant mechanisms are still poorly understood. So fa...

journal_title：Neuroscience letters

authors： Brenner S,Wersinger C,Gasser T

更新日期：2015-07-10 00:00:00

abstract：:A remarkable candidate gene for late-onset Alzheimer's disease (AD) is 24-dehydrocholesterol reductase (DHCR24) gene that encodes seladin-1 (selective AD indicator), an enzyme that is involved in the cholesterol biosynthetic pathway, exerts neuroprotective and anti-apoptotic effects, and found to be down regulated in ...

journal_title：Neuroscience letters

authors： Fehér A,Juhász A,Pákáski M,Kálmán J,Janka Z

更新日期：2012-09-20 00:00:00

abstract：:In gastropods, the interneuronal messenger, nitric oxide (NO), modulates spike frequency and synaptic transmission. We have characterized the effect of NO on ion currents underlying neuronal excitability, using current-clamp and two-electrode voltage-clamp techniques. Identified neurons of the pulmonate snail, Helix p...

journal_title：Neuroscience letters

authors： Zsombok A,Schrofner S,Hermann A,Kerschbaum HH

更新日期：2000-12-08 00:00:00

abstract：:Hyperactivity of the hypothalamic-pituitary-adrenal axis is associated with depression. We investigated the effect of various types of antidepressant agents in vitro on the function of glucocorticoid receptor (GR). Desipramine, clomiplamine, fluoxetine, milnacipran and clorgyline all induced rapid and sustained transl...

journal_title：Neuroscience letters

authors： Okuyama-Tamura M,Mikuni M,Kojima I

更新日期：2003-05-22 00:00:00

abstract：:The effect of oleamide on apoptosis was investigated by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay, DNA staining assay with propidium iodide and caspase-3 activity analyses. The present results showed that oleamide significantly attenuated the cell death and nuclear condensation...

journal_title：Neuroscience letters

authors： Yang JY,Abe K,Xu NJ,Matsuki N,Wu CF

更新日期：2002-08-09 00:00:00

abstract：:In situ whole cell voltage clamp recordings of presumed folliculo-stellate cells were made in the intermediate lobe of the clawed toad Xenopus laevis. Lucifer Yellow fillings revealed, in addition to the small, spherical melanotropes, a population of larger cells with many processes that were, to a limited extent, dye...

journal_title：Neuroscience letters

authors： Borst JG,Lodder JC,Roubos EW,Kits KS

更新日期：1996-05-03 00:00:00

abstract：:Aquaporins are involved in the maintenance of ionic and osmotic balance in the central nervous system and in the eye. Whereas the expression of aquaporin-9 immunoreactivity in the brain has been described for catecholaminergic neurons and glial cells, the expression of aquaporin-9 in the neural retina is unclear. We e...

journal_title：Neuroscience letters

authors： Iandiev I,Biedermann B,Reichenbach A,Wiedemann P,Bringmann A

更新日期：2006-05-08 00:00:00

abstract：:Application of NMDA, or agents releasing nitric oxide (NO), onto the dendrites of hippocampal granule cells increased the levels of the mRNA encoding MAP2, a cytoskeletal component induced during periods of neurite outgrowth. Furthermore, local increases in the hybridisation signal in the molecular layer, representing...

journal_title：Neuroscience letters

authors： Johnston HM,Morris BJ

更新日期：1994-08-15 00:00:00

abstract：:Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicated in neuroprotection in cerebral ischemia. Administered as pretreatment, diazoxide can attenuate ischemia-related neuronal injury, but little is known about the potential neuroprotective properties of the drug when it ...

journal_title：Neuroscience letters

authors： Farkas E,Timmer NM,Domoki F,Mihály A,Luiten PG,Bari F

更新日期：2005-10-28 00:00:00

abstract：:By using a monoclonal antibody and polyclonal antibodies to human beta amyloid precursor protein (APP), we immunohistochemically examined axonal swellings (spheroids). The immunoreactivity of APP was observed in numerous spheroids, which were found around the areas of old cerebral infarctions, in the globus pallidus w...

journal_title：Neuroscience letters

authors： Ohgami T,Kitamoto T,Tateishi J

更新日期：1992-02-17 00:00:00

abstract：:In the rat, unilateral dorsal cervicothoracic rhizotomy (C5-T2) resulted in autotomy of the ipsilateral limb. The onset of self-mutilation was variable and attained the maximum degree 8-9 weeks after the dorsal root section. Fifteen and 60 days after the lesion the monoamines dopamine (DA), noradrenaline (NA) and sero...

journal_title：Neuroscience letters

authors： Colado MI,Arnedo A,Peralta E,Del Río J

更新日期：1988-05-03 00:00:00

abstract：:The presence of serotonin (5-HT)-like immunoreactivity has been detected in ganglionar cell bodies of the nodose ganglia of the cat, using the peroxidase-antiperoxidase immunohistochemical method, applied to sections of ganglia previously embedded in paraffin. The antibodies were raised in rabbits following injection ...

journal_title：Neuroscience letters

authors： Gaudin-Chazal G,Portalier P,Barrit MC,Puizillout JJ

更新日期：1982-11-30 00:00:00