Injection of capsaicin into the nucleus raphe dorsalis elicits heat loss in the rat.

Abstract:

:The acute thermoregulatory effect of microinjection of capsaicin into the nucleus raphe dorsalis (NRD) has been studied in anesthetised rats. Application of capsaicin (20 micrograms) into the NRD increased the tail skin temperature and decreased the body temperature. In animals that had previously been treated with capsaicin (50 mg/kg s.c.) the thermolytic effect of capsaicin microinjection was completely abolished. Additionally, the effects of NRD capsaicin injection on the monoamines in the preoptic region + hypothalamus (RPO-H) were studied. Levels of noradrenaline, dopamine, serotonin, 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were determined by means of liquid chromatography. Neurochemical analysis of RPO-H showed no changes in the serotonin metabolism, but an elevated DOPAC level 30 min after the injection of capsaicin into the NRD.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Hajós M,Hjorth S,Carlsson A

doi

10.1016/0304-3940(87)90297-7

subject

Has Abstract

pub_date

1987-03-31 00:00:00

pages

199-204

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(87)90297-7

journal_volume

75

pub_type

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