Different effects of amino acids, acetylcholine and monoamines on neuronal activity of suprachiasmatic nucleus in rat pups and adults.

Abstract:

:A study was undertaken of the effects of iontophoretically applied amino acids, acetylcholine and monoamines on suprachiasmatic nucleus (SCN) neurons of rat pups, at the 11th postnatal day, using a hypothalamic slice preparation. GABA and taurine inhibited 97 and 42% of SCN neurons, respectively, while glycine had no effect. Glutamate excited 68% of them. These effects were similar to those in adult rats. Serotonin and noradrenaline inhibited 6 and 10% of SCN neurons, respectively, in rat pups, whereas 32 and 26% of them were inhibited in adult rats. Acetylcholine excited 7% but inhibited 26% of SCN neurons in rat pups and these values were almost the same as those of adult rats. These results reveal that acetylcholine and amino acids regulate SCN neurons even in rat pups, whereas monoamines play an important regulatory role in SCN activity in adult rats only.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Shibata S,Liou SY,Ueki S

doi

10.1016/0304-3940(83)90075-7

subject

Has Abstract

pub_date

1983-08-29 00:00:00

pages

187-92

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(83)90075-7

journal_volume

39

pub_type

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