Super-resolution microscopy for analyzing neuromuscular junctions and synapses.

abstract：:The association of alpha-synuclein (alpha-syn) neuropathology with Parkinson's disease (PD) and several related disorders has led to an intense research effort to develop cerebrospinal fluid (CSF)- or blood-based alpha-syn biomarkers for these types of diseases. Recent studies show that alpha-syn is present in CSF and...

journal_title：Neuroscience letters

authors： Ohrfelt A,Grognet P,Andreasen N,Wallin A,Vanmechelen E,Blennow K,Zetterberg H

更新日期：2009-02-06 00:00:00

abstract：:The nicotinic acetylcholine receptor (nAChR) antagonist alpha-bungarotoxin (alpha-Btx) binds to two different classes of high affinity binding sites from the Drosophila central nervous system. We have used the bivalent reagent 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDAC) to cross-link 125I-alpha-Btx (M(r) = ...

journal_title：Neuroscience letters

authors： Schloss P,Mayser W,Gundelfinger ED,Betz H

更新日期：1992-09-28 00:00:00

abstract：:A culture of peripheral nerve cells enriched in Schwann cells was obtained from sciatic nerve in normal and demyelinating trembler mutant. These cells incorporated and metabolized a non-physiological trans fatty acid (elaidic aid) as well as the physiological cis isomer (oleic acid). Both acids were incorporated simil...

journal_title：Neuroscience letters

authors： Bourre JM,Boutry JM,Masson M,Hauw JJ

更新日期：1982-05-28 00:00:00

abstract：:We determined the effect of naloxone and morphine on the differentiation of pheochromocytoma cell, the PC12 cells, induced by nerve growth factor (NGF). PC12 cells were grown in medium containing NGF with or without the addition of naloxone or morphine for up to 10-day treatments. NGF-induced morphological differentia...

journal_title：Neuroscience letters

authors： Yeh GC,Hsieh TH,Chang SF

更新日期：1998-08-07 00:00:00

abstract：:Mammalian olfactory sensory neurons (OSNs), the primary elements of the olfactory system, are located in the olfactory epithelium lining the nasal cavity. Exposed to the environment, their lifespan is short. Consequently, OSNs are regularly regenerated and several reports show that activity strongly modulates their de...

journal_title：Neuroscience letters

authors： Molinas A,Aoudé I,Soubeyre V,Tazir B,Cadiou H,Grosmaitre X

更新日期：2016-07-28 00:00:00

abstract：:The neurotoxicity of the glutamate receptor agonists N-methyl-D-aspartate (NMDA), (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), and kainate was quantitatively assessed in murine spinal cord and cortical cultures prepared under identical conditions. Compared with cortical neurons, spinal neuron...

journal_title：Neuroscience letters

authors： Regan RF

更新日期：1996-07-26 00:00:00

abstract：:The phenotype of neurotrophin-3 (NT-3) null mutant mice is characterized by sensory ataxia and early postnatal death. Previous analysis revealed a severe depletion of peripheral sensory, sympathetic and parasympathetic neurons. Most of the deficits are established early during embryonic development. Whereas absence of...

journal_title：Neuroscience letters

authors： Barski JJ,Helbig C,Meyer M

更新日期：2011-09-01 00:00:00

abstract：:Linkage studies have implicated a broad region on chromosome 10q in Alzheimer's disease (AD). A recent genetic association study has provided evidence that polymorphism in the gene encoding alpha-3 catenin (CTNNA3, referred to previously as VR22 and also known as alpha-T catenin) may underlie linkage signals. Here, to...

journal_title：Neuroscience letters

authors： Blomqvist ME,Andreasen N,Bogdanovic N,Blennow K,Brookes AJ,Prince JA

更新日期：2004-04-01 00:00:00

abstract：:Dimensions and innervation of muscle fibers in locust jumping muscle from 1st instar larva and adult are compared. Fibers innervated by only one motoneuron were investigated. During postembryonic development, the size, but not the number, of muscle fibers increases. The number of synaptic contacts per fiber increases ...

journal_title：Neuroscience letters

authors： Walther C

更新日期：1981-12-23 00:00:00

abstract：:Maternal infection during pregnancy increases the risk of neurodevelopmental conditions such as autism spectrum disorders and schizophrenia in offspring. Several previous animal studies have indicated that maternal immune activation (MIA), rather than a specific pathogen, alters fetal brain development. Among them, pr...

journal_title：Neuroscience letters

authors： Zuiki M,Chiyonobu T,Yoshida M,Maeda H,Yamashita S,Kidowaki S,Hasegawa T,Gotoh H,Nomura T,Ono K,Hosoi H,Morimoto M

更新日期：2017-07-13 00:00:00

abstract：:Using double-staining techniques, the distribution of NADPH-diaphorase (ND)- and nitric oxide synthase (NOS)-positive cells was compared in the periglomerular region of typical and atypical rat olfactory glomeruli. Dorsomedial and ventrolateral atypical glomeruli contained similar number of ND/NOS-positive periglomeru...

journal_title：Neuroscience letters

authors： Crespo C,Porteros A,Arévalo R,Briñón JG,Aijón J,Alonso JR

更新日期：1996-03-01 00:00:00

abstract：:Amphiphysin II (Amph2) is known to undergo rapid dephosphorylation and phosphorylation at nerve terminals. After in vivo electroconvulsive shock (ECS) in the rat cerebellum, we found an electrophoretic mobility retardation of Amph2, which suggested an increased degree of phosphorylation above the non-stimulated level....

journal_title：Neuroscience letters

authors： Koo YJ,Kim SJ,Jeon SH,Kim SR,Kang UG,Park JB,Kim YS

更新日期：2002-09-20 00:00:00

abstract：:Autism spectrum disorders are characterized by impaired social and communication skills and seem to result from altered neural development. We sought to determine whether the anatomy of the meninges and extracellular matrix (ECM) is altered in an animal model of autism, the BTBR T+ tf/J mouse. This mouse displays whit...

journal_title：Neuroscience letters

authors： Mercier F,Cho Kwon Y,Kodama R

更新日期：2011-07-12 00:00:00

abstract：:To study the neuronal mechanism of a conditioned taste-aversion (CTA) learning in the pond snail Lymnaea stagnalis, we examined the synaptic connection between the neuron 1 medial (N1M) cell and the cerebral giant cell (CGC), the former is an interneuron in central pattern generator for the feeding response and the la...

journal_title：Neuroscience letters

authors： Kojima S,Nanakamura H,Nagayama S,Fujito Y,Ito E

更新日期：1997-07-25 00:00:00

abstract：:It is widely held that transdiaphragmatic pressure is a reliable index of the extent of central activation of the diaphragm but the maximal voluntary transdiaphragmatic pressure is lower during inspiratory than expulsive efforts. To determine whether the diaphragm is fully activated during the two manoeuvres supramaxi...

journal_title：Neuroscience letters

authors： McKenzie DK,Plassman BL,Gandevia SC

更新日期：1988-06-17 00:00:00

abstract：:Previous studies from our team have shown that a 12 month ethanol administration induced deficits in a sequential alternation task, whereas a 6 month treatment had no effects. We have already shown that the 12 month treatment induced deficits both in diencephalic and hippocampal structures, whereas the 6 month treatme...

journal_title：Neuroscience letters

authors： Beracochea D,Jaffard R

更新日期：1991-12-16 00:00:00

abstract：:Microglia are resident immune cells of brain and activated by peripheral tissue injury. In the present study, we investigated the possible induction of several microglial surface immunomolecules in the spinal cord, including leukocyte common antigen (LCA/CD45), MHC class I antigen, MHC class II antigen, Fc receptor, a...

journal_title：Neuroscience letters

authors： Fu KY,Tan YH,Sung B,Mao J

更新日期：2009-01-16 00:00:00

abstract：:The prioritized processing of threat is suggested to be motivated by anxiety, regulated by the parasympatheticus, and biased to the right hemisphere. However, according to an anterior dimensional model of negative affect this is unlikely to be true when threat is of social origin. Social threat is communicated by the ...

journal_title：Neuroscience letters

authors： van Honk J,Hermans EJ,d'Alfonso AA,Schutter DJ,van Doornen L,de Haan EH

更新日期：2002-02-15 00:00:00

abstract：:In experiments using a synaptosomal preparation from the striatum and nucleus accumbens, somatostatin caused a dose-dependent increase in dopamine synthesis. This increase was additive with that produced by 8-BrcAMP but not with that produced by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), and was bl...

journal_title：Neuroscience letters

authors： Chowdhury M,Steardo L,Fillenz M

更新日期：1987-11-23 00:00:00

abstract：:Central administration of C-type natriuretic peptide (CNP) affects various neuroendocrine systems. In the present study, we examined whether CNP acts directly on arginine-vasopressin (AVP) secretion from rat supraoptic nucleus (SON) neurons, using acute dissociated cell preparations. CNP inhibited the basal secretion ...

journal_title：Neuroscience letters

authors： Yamamoto S,Morimoto I,Yanagihara N,Kangawa K,Inenaga K,Eto S,Yamashita H

更新日期：1997-06-27 00:00:00

abstract：:The effect of electrical stimulation of the dorsal hippocampus on accumbens dopamine release was examined. Stimulation of the kindled hippocampus that produced stage 3 seizures evoked a brief increase in extracellular DA and DOPAC levels in the contralateral nucleus accumbens. In contrast, similar stimulation early in...

journal_title：Neuroscience letters

authors： Strecker RE,Moneta ME

更新日期：1994-08-01 00:00:00

abstract：:Morphine injections in 16-day-old rats caused an increase in norepinephrine concentration in both superior cervical ganglion and iris after 1 h. Although the increase in the ganglion was blocked by naloxone pretreatment, the increase in the iris was not prevented. The morphine-induced increase did not require the pres...

journal_title：Neuroscience letters

authors： Mattio TG,Kirby ML

更新日期：1983-09-09 00:00:00

abstract：:Alternate serial 1 micron Durcupan resin sections of tiger salamander retina were stained with antisera against GABA and glycine using postembed immunocytochemical techniques. Although the vast majority of neurons were labeled by either GABA or glycine antiserum, a small percentage of presumed amacrine cells in the in...

journal_title：Neuroscience letters

authors： Yazulla S,Yang CY

更新日期：1988-12-19 00:00:00

abstract：:2-Deoxy-d-glucose (2DG) is an analog of glucose that is effectively taken up by cells competing with normal glucose but cannot be further utilized to produce energy. It was previously reported that 2DG can mimic the beneficial effects of dietary restriction in experimental models of neurodegenerative disorders and can...

journal_title：Neuroscience letters

authors： Park M,Song KS,Kim HK,Park YJ,Kim HS,Bae MI,Lee J

更新日期：2009-01-16 00:00:00

abstract：:Turnover rates, as estimated from the accumulation of the intermediates, 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition, were used to investigate the relationship between central catecholaminergic and serotonergic neurons and the development of hypertension in the ...

journal_title：Neuroscience letters

authors： Shum AY,Chen CS,Hsu SC,Chen CF

更新日期：1987-03-31 00:00:00

abstract：:Alzheimer's disease has become one of the most impacting disorders since world population is rapidly aging. MicroRNA-125b plays a crucial role in many cellular processes and pathologies, but, to date, its role in Alzheimer's disease is controversial. In this study, we demonstrated, for the first time, that the down re...

journal_title：Neuroscience letters

authors： Micheli F,Palermo R,Talora C,Ferretti E,Vacca A,Napolitano M

更新日期：2016-08-26 00:00:00

abstract：:The effects of aging on the stress response of the septo-hippocampal cholinergic neurons was assessed by monitoring hippocampal acetylcholine (ACh) release. Young (3-4 month old) and aged (23-24 month old) male rats were subjected to restraint stress for 1 h. ACh was elevated within 15 min of the onset of restraint st...

journal_title：Neuroscience letters

authors： Mizuno T,Kimura F

更新日期：1997-01-24 00:00:00

abstract：:Tryptophan hydroxylase 2 (TPH2) is a rate-limiting enzyme of neuronal serotonin biosynthesis. Recently, two single nucleotide polymorphisms (SNPs) at the exon 11 coding region that resulted in amino acid substitutions in the C-terminal domain have been reported to affect enzyme activity in humans and mice. We determin...

journal_title：Neuroscience letters

authors： Hong KW,Sugawara Y,Hasegawa H,Hayasaka I,Hashimoto R,Ito S,Inoue-Murayama M

更新日期：2007-02-02 00:00:00

abstract：:We studied the altered molecular species of lipids in brain and liver tissues, and fibroblasts from patients with Zellweger syndrome (ZS). ZS cerebellum samples contained a higher amount of sphingomyelin with shorter chain fatty acids compared to that in normal controls. The amount of phosphatidylethanolamine (PE) was...

journal_title：Neuroscience letters

authors： Miyazaki C,Saitoh M,Itoh M,Yamashita S,Miyagishi M,Takashima S,Moser AB,Iwamori M,Mizuguchi M

更新日期：2013-09-27 00:00:00

abstract：:It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and projects to several forebrain structures, is known to be criticall...

journal_title：Neuroscience letters

authors： Zacarias MS,Ramos AC,Alves DR,Galduróz JC

更新日期：2012-04-04 00:00:00