Protein kinase C mediates the stimulation by somatostatin of dopamine synthesis in the rat striatum and nucleus accumbens.

Abstract:

:In experiments using a synaptosomal preparation from the striatum and nucleus accumbens, somatostatin caused a dose-dependent increase in dopamine synthesis. This increase was additive with that produced by 8-BrcAMP but not with that produced by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), and was blocked by the protein kinase C inhibitor polymyxin B (PMB). These findings suggest that stimulation of dopamine synthesis by somatostatin is mediated by activation of protein kinase C.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Chowdhury M,Steardo L,Fillenz M

doi

10.1016/0304-3940(87)90129-7

subject

Has Abstract

pub_date

1987-11-23 00:00:00

pages

196-200

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(87)90129-7

journal_volume

82

pub_type

杂志文章