Abstract:
:In experiments using a synaptosomal preparation from the striatum and nucleus accumbens, somatostatin caused a dose-dependent increase in dopamine synthesis. This increase was additive with that produced by 8-BrcAMP but not with that produced by the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), and was blocked by the protein kinase C inhibitor polymyxin B (PMB). These findings suggest that stimulation of dopamine synthesis by somatostatin is mediated by activation of protein kinase C.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chowdhury M,Steardo L,Fillenz Mdoi
10.1016/0304-3940(87)90129-7subject
Has Abstractpub_date
1987-11-23 00:00:00pages
196-200issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(87)90129-7journal_volume
82pub_type
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