当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > [125I]dynorphin(1-8) produces a similar pattern of kappa-opioid receptor labelling to [3H]dynorphin(1-8) and [3H]etorphine in guinea pig brain: a quantitative autoradiographic study.

[125I]dynorphin(1-8) produces a similar pattern of kappa-opioid receptor labelling to [3H]dynorphin(1-8) and [3H]etorphine in guinea pig brain: a quantitative autoradiographic study.

Abstract：

:kappa-Opioid receptors were radiolabelled with the peptides [125I]dynorphin(1-8) and [3H]dynorphin(1-8) or with [3H]etorphine on guinea pig forebrain and cerebellar sections and visualized by quantitative autoradiography. All three radioligands yielded similar patterns of kappa-receptor localization. However, quantitative analysis showed that using saturating concentrations of the tritiated radioligands the apparent density of specific [3H]etorphine-labelled kappa-sites was 1.5-5.4 times greater than that achieved with [3H]dynorphin(-8). The apparent rank order of regional density of kappa-sites on a quantitative basis with all 3 radioligands was similar. A high density of kappa-receptors was found in the nucleus accumbens, striatum, globus pallidus, cerebral cortex (layers V-VI), hippocampal and cerebellar molecular layers, substantia nigra and substantia gelatinosa of the spinal cord. A lower density of these sites was associated with the thalamus, hypothalamus and the amygdaloid complex. Thus, in view of the advantages of using iodinated ligands in autoradiography this study has shown that [125I]dynorphin(1-8) is an acceptable ligand for labelling kappa-receptors in the brain.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Sharif NA,Hunter JC,Hill RG,Hughes J

doi

10.1016/0304-3940(88)90495-8

subject

Has Abstract

pub_date

1988-04-12 00:00:00

pages

272-8

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(88)90495-8

journal_volume

86

pub_type

杂志文章

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