Abstract：
:Linkage studies have implicated a broad region on chromosome 10q in Alzheimer's disease (AD). A recent genetic association study has provided evidence that polymorphism in the gene encoding alpha-3 catenin (CTNNA3, referred to previously as VR22 and also known as alpha-T catenin) may underlie linkage signals. Here, to investigate this finding, markers that previously exhibited maximum evidence of association have been tested in Swedish and Scottish AD case-control samples. Across models of disease risk and in relation to multiple quantitative indices of AD pathology (CSF A beta 42 and tau levels, age-at-onset, MMSE scores, and measures of senile plaque density) no evidence was found supporting a role for these particular variants in AD. More detailed studies of regional linkage disequilibrium structure around CTNNA3 will likely be required to determine whether sequence variation in this region impacts AD.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Blomqvist ME,Andreasen N,Bogdanovic N,Blennow K,Brookes AJ,Prince JAdoi
10.1016/j.neulet.2004.01.032keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
220-2issue
3eissn
0304-3940issn
1872-7972pii
S0304394004000953journal_volume
358pub_type
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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pub_type： 杂志文章
doi：10.1016/j.neulet.2007.12.017
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pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1999-03-05 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.10.037
更新日期：2007-01-22 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2004-08-26 00:00:00
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journal_title：Neuroscience letters
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2011-08-18 00:00:00
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pub_type： 杂志文章,随机对照试验
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
pub_type： 杂志文章
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abstract：:Tonsils have a privileged situation in the immune system in that they are in touch with the environment. Melatonin is a hormone that is influenced by the circadian environmental variations of dark-light and is a modulator of the immune system. We have studied a group of thirty five children with recurrent acute tonsil...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00292-4
更新日期：1998-05-15 00:00:00
