H2O2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin.


:Melatonin protection against H2O2-induced lipid peroxidation in brain homogenates was measured in vitro. The level of malonaldehyde (MDA) plus 4-hydroxyalkenals (4-HDA) was assayed in brain homogenates as an index of induced membrane oxidative damage. Brain homogenates were co-incubated with H2O2 alone or in combination with melatonin. Brain MDA + 4-HDA increased after H2O2 (0.1-5 mM) with the effect being both concentration- and time-dependent. Melatonin (0.1-5 mM) protected against H2O2-induced lipid peroxidation of brain homogenates in a concentration-dependent manner.


Neurosci Lett


Neuroscience letters


Sewerynek E,Poeggeler B,Melchiorri D,Reiter RJ




Has Abstract


1995-08-11 00:00:00














  • Relative enrichment of the lighter 59 kDa form of glutamic acid decarboxylase in nerve endings: an immunoblotting study in pituitary neurointermediate lobe.

    abstract::Previous studies established that glutamate decarboxylase (GAD) is present in the brain of higher vertebrates in two forms composed of the homodimeric association of two subunits 59 and 63 kDa, respectively, that were found to be structurally related. We have performed quantitative comparative immunoblotting of whole ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Henry S,Tappaz M

    更新日期:1991-10-14 00:00:00

  • Protective effect of carnosine on febrile seizures in immature mice.

    abstract::Febrile seizures (FSs) are the most common type of convulsions in childhood and complex FSs represent an increased risk for development of temporal lobe epilepsy. The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia ind...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Dai YJ,Wu DC,Feng B,Hou WW,Xu CL,Ohtsu H,Chen Z,Hu WW

    更新日期:2015-02-19 00:00:00

  • Personality traits and negative affect mediate the relationship between cortical thickness of superior frontal cortex and aggressive behavior.

    abstract::Aggression reflects the psychological and physical behavior that perpetrator intends to harm victim. Initiation of aggression is influenced by the distal factors (e.g. personality) and proximate causes (e.g. affect) of perpetrator. However, few studies explored the brain structural basis of relationship between these ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Zhu X,Wang K,Cao A,Zhang Y,Qiu J

    更新日期:2020-01-23 00:00:00

  • Slow isomerization step in the interaction between mouse dopamine transporter and dopamine re-uptake inhibitor N-(3-iodoprop-2E-enyl)-2beta-carbo-[3H]methoxy-3beta-(4'-methylphenyl)nortropane.

    abstract::The kinetics of the association and dissociation of the tritium-labeled selective and potent dopamine transporter inhibitor N-(3-iodoprop-2E-enyl)-2beta-carbo-[3H]methoxy-3beta-(4'-methylphenyl)nortropane ([3H]PE2I) with the transporter of mouse striatal membranes was studied. The analysis revealed that the specific b...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Stepanov V,Järv J

    更新日期:2006-12-27 00:00:00

  • Induction of the Oct-2 transcription factor in primary sensory neurons during inflammation is nerve growth factor-dependent.

    abstract::The mRNA encoding the POU family transcription factor Oct-2 is induced in cultured adult sensory neurons following treatment with nerve growth factor (NGF) but not with a variety of other growth factors. We show here that the Oct-2 mRNA is also upregulated in vivo in sensory neurons innervating inflamed tissue followi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ensor E,Kendall G,Allchorne A,Woolf CJ,Latchman DS

    更新日期:1996-02-02 00:00:00

  • Time course of recovery of the somatosensory map following hindpaw sensory deprivation in the rat.

    abstract::Hindlimb sensory deprivation is known to induce a decrease in the cortical representation of hindpaw, and an increase in the size of the cutaneous receptive fields. The aim of the present study was to determine (i) the time-course of recovery when the rat retrieves a normal use of its limbs after a 14-day period of se...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Dupont E,Canu MH,Langlet C,Falempin M

    更新日期:2001-08-24 00:00:00

  • Preadolescent dopamine receptor antagonism increases postadolescent reward-related operant behaviors that may depend on dopamine receptor hypersensitivity.

    abstract::The dopaminergic system has a long history of being associated with reward-related activities but the developmental consequences of blocking dopamine receptor function on reward-based associative learning has been less studied. To this end, male, Long Evans rats were systemically (i.p.) treated with the dopamine recep...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Holahan MR,Goheen K

    更新日期:2020-04-23 00:00:00

  • Intrathecal administration of the adenosine A1 receptor agonist R-phenylisopropyl adenosine reduces presumed pain behaviour in a rat model of central pain.

    abstract::Effects of intrathecally (i.t.) administered R-phenylisopropyl adenosine (R-PIA), an adenosine A1 receptor agonist, on presumed pain behaviour were assessed in a rat model of chronic central pain. Spinal cord injury was induced photochemically via laser irradiation of the spinal cord after intravenous injection of ery...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Sjölund KF,von Heijne M,Hao JX,Xu XJ,Sollevi A,Wiesenfeld-Hallin Z

    更新日期:1998-02-27 00:00:00

  • Sexual differences and seasonal variations in vasoactive intestinal peptide immunoreactivity in the suprachiasmatic nucleus of jerboa (Jaculus orientalis).

    abstract::The sexual differences and the seasonal variation in the vasoactive intestinal peptide (VIP) content of the suprachiasmatic nucleus (SCN) of a desert rodent, the jerboa (Jaculus orientalis) were studied using immunocytochemical techniques. During the period of sexual activity (spring-early summer), the VIP immunoreact...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lakhdar-Ghazal N,Kalsbeek A,Pevet P

    更新日期:1992-09-14 00:00:00

  • IL-4 is the key regulator in herpes simplex virus-based gene therapy of BALB/c experimental autoimmune encephalomyelitis.

    abstract::Local delivery of cytokines or other immunomodulatory components has been applied as a potential therapy for experimental autoimmune encephalomyelitis (EAE), which is used as a model of human multiple sclerosis. We have used herpes simplex virus-based vectors expressing Th2 cytokines IL-4 and IL-10 and have previously...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Broberg EK,Salmi AA,Hukkanen V

    更新日期:2004-07-08 00:00:00

  • No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients.

    abstract::Amyloid beta-peptide (Abeta) deposition in brain is important in the development of Alzheimer's disease (AD). Neprilysin (NEP) appears to be the major Abeta degrading enzyme in vivo and reduced mRNA levels of NEP correlates with increased plaque density. We hypothesized that alterations in the NEP promoter region may ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lilius L,Forsell C,Axelman K,Winblad B,Graff C,Tjernberg L

    更新日期:2003-02-06 00:00:00

  • Leucine-enkephalin-like immunoreactive afferent fibers to pudendal motoneurons in the cat.

    abstract::Leucine-enkephalin-like immunoreactive (ENK-LI) afferent fibers to the feline homologue of the Onuf's nucleus (pudendal motoneurons) originate mainly from lamina X of the sacral cord. They make synaptic contacts chiefly upon dendrites of pudendal motoneurons; the synaptic terminals most often contain pleomorphic synap...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

    更新日期:1985-10-24 00:00:00

  • Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice.

    abstract::Nor-binaltorphimine (nor-BNI) is kappa opioid receptor (KOR) antagonist with the extremely long duration in mice analgesic assay, in vivo. For the evaluation of long-lasting effect of nor-BNI, brain content and serum concentration of nor-BNI were quantified in comparison with those of naloxone (a short-acting non-spec...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kishioka S,Kiguchi N,Kobayashi Y,Yamamoto C,Saika F,Wakida N,Ko MC,Woods JH

    更新日期:2013-09-27 00:00:00

  • Voltage-dependency of the dopamine transporter in the rat substantia nigra.

    abstract::The possible voltage-dependence of the dopamine transporter (DAT) was investigated using electrophysiological and electrochemical recordings in rat brain slices containing the substantia nigra (SN). Whole-cell patch clamp recordings of DA neurons, revealed that addition of 15 mM KCl rapidly depolarized the membrane po...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Hoffman AF,Zahniser NR,Lupica CR,Gerhardt GA

    更新日期:1999-01-29 00:00:00

  • Intracellular recordings from two cell types in an in vitro preparation of the salamander olfactory epithelium.

    abstract::Two electrophysiologically distinct cell types were found with intracellular recordings for the first time in an in vitro preparation of the olfactory epithelium of the salamander, Ambystoma tigrinum. Intracellular recordings showed that Type I cells did not discharge action potentials but had high resting membrane po...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Masukawa LM,Kauer JS,Shepherd GM

    更新日期:1983-01-31 00:00:00

  • Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy.

    abstract::Sepsis-associated encephalopathy (SAE) has significant impact on the neurocognitive outcome of sepsis survivors. This study was conducted to analyze the amino-terminal propeptide of the C-type natriuretic peptide (NT-proCNP) as a biomarker for SAE in comparison to neuron-specific enolase (NSE) and S100B protein. Cereb...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ehler J,Saller T,Wittstock M,Rommer PS,Chappell D,Zwissler B,Grossmann A,Richter G,Reuter DA,Nöldge-Schomburg G,Sauer M

    更新日期:2019-01-23 00:00:00

  • Protective effect of telmisartan against oxidative damage induced by high glucose in neuronal PC12 cell.

    abstract::Telmisartan is an angiotensin II type 1 receptor blocker and partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). Here, we investigated the protective capacity of telmisartan against high glucose (HG)-elicited oxidative damage in PC12 cells. The activity of lactate dehydrogenase (LDH), NADPH o...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Eslami H,Sharifi AM,Rahimi H,Rahati M

    更新日期:2014-01-13 00:00:00

  • An industry perspective on the role and utility of animal models of pain in drug discovery.

    abstract::In recent years, animal behavioral models, particularly those used in pain research, have been increasingly scrutinized and criticized for their role in the poor translation of novel pharmacotherapies for chronic pain. This article addresses the use of animal models of pain from the perspective of industrial drug disc...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,评审


    authors: Whiteside GT,Pomonis JD,Kennedy JD

    更新日期:2013-12-17 00:00:00

  • A refractory period after brief activation of mammalian skeletal muscle fibres.

    abstract::A two pulse technique was used to study the decay of mechanical activation in TTX poisoned mouse extensor digitorum longus (EDL) and soleus muscle fibres. A two microelectrode point voltage clamp technique was used with visual endpoint determination of the threshold potential for activation. The excitatory effect of a...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Dulhunty AF

    更新日期:1979-10-01 00:00:00

  • Genetic association analysis of serotonin and signal transduction pathways in suicide attempters from an Italian sample of psychiatric patients.

    abstract::Genetic factors have been reported to contribute to the liability of suicide. We aimed to investigate functional polymorphisms in eight genes (serotonin transporter, SLC6A4; receptors, 5HTR1A, 1B, 5HTR2A; Tryptophan Hydroxylase, TPH1, TPH2; Monoamine Oxidase, MAOA and G Protein Subunit Beta 3, GNB3) to investigate the...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Pompili M,Gentile G,Scassellati C,Bonvicini C,Innamorati M,Erbuto D,Montebovi F,Ducci G,Forte A,De Pisa E,Ferracuti S,Serafini G,De Luca V,Amore M,Simmaco M,Girardi P

    更新日期:2017-08-24 00:00:00

  • Tau gene polymorphisms and apolipoprotein E epsilon4 may interact to increase risk for Alzheimer's disease.

    abstract::In an effort to analyze the genetic role of tau in Alzheimer's disease (AD), 17 polymorphisms were identified. Eleven of these polymorphisms were in complete linkage disequilibrium and segregated as two haplotypes, A and B. The A and B haplotypes were investigated in 269 AD cases and 238 controls from two different so...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lilius L,Froelich Fabre S,Basun H,Forsell C,Axelman K,Mattila K,Andreadis A,Viitanen M,Winblad B,Fratiglioni L,Lannfelt L

    更新日期:1999-12-17 00:00:00

  • Aging-related changes in auditory and visual integration measured with MEG.

    abstract::As noted in the aging literature, processing delays often occur in the central nervous system with increasing age, which is often attributable in part to demyelination. In addition, differential slowing between sensory systems has been shown to be most discrepant between visual (up to 20ms) and auditory systems (<5ms)...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Stephen JM,Knoefel JE,Adair J,Hart B,Aine CJ

    更新日期:2010-10-22 00:00:00

  • Effect of chronic alcohol consumption on Go protein in rat brain.

    abstract::Almost all of the important pathophysiological targets for ethanol in the nervous system appear to be specific membrane proteins involved in signal transduction. In this paper we have examined levels and functionality of the alpha subunit of the Go protein (Goalpha) in cerebral cortex and cerebellum from rats that hav...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Guillén A,García-Villafranca J,Mata F,Homburger V,Castro J

    更新日期:2003-12-26 00:00:00

  • Accelerated functional recovery and neuroprotection by agmatine after spinal cord ischemia in rats.

    abstract::Treatment with agmatine, decarboxylated arginine, proved to be non-toxic and to exert neuroprotective effects in several models of neurotoxic and ischemic brain and spinal cord injuries. Here we sought to find out whether agmatine treatment would also prove beneficial in a rat spinal cord ischemia model (balloon occlu...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Gilad GM,Gilad VH

    更新日期:2000-12-22 00:00:00

  • Voltammetry in unanesthetized rat: increases of striatal dopamine turnover after unilateral haloperidol injection into the substantia nigra.

    abstract::In freely moving rats, effects of unilateral haloperidol injection into the substantia nigra were monitored with in vivo voltammetry in the bilateral striata. The electrochemical responses at 120 mV versus Ag-AgCl, reflecting mainly a level of 3,4-dihydroxyphenylacetic acid (DOPAC), increased both in the striata withi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Kato T,Ishii K,Ikeda M

    更新日期:1984-09-07 00:00:00

  • Regulation of the priming of exocytosis and the dissociation of SNAP-25 and VAMP-2 in adrenal chromaffin cells.

    abstract::The MgATP-dependent priming step of exocytosis has been suggested to be regulated negatively by GTP-binding protein G0 in permeabilized adrenal chromaffin cells. We have reported that synaptosomal-associated protein of 25 kDa (SNAP-25) and vesicle-associated membrane protein 2 (VAMP-2) form a complex in chromaffin cel...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Misonou H,Ohara-Imaizumi M,Kumakura K

    更新日期:1997-09-05 00:00:00

  • A partial L5 spinal nerve ligation induces a limited prolongation of mechanical allodynia in rats: an efficient model for studying mechanisms of neuropathic pain.

    abstract::The relationship between pain severity and the extent of injury to a peripheral nerve remains elusive. In this study, we compared the pain behavior resulting from partial (1/3-1/2 thickness) and full L5 spinal nerve ligation (SNL) in rats. The decrease in paw withdrawal threshold (PWT) to mechanical stimuli in the hin...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Guan Y,Yuan F,Carteret AF,Raja SN

    更新日期:2010-02-26 00:00:00

  • Simulation of the geomagnetic field experienced by the International Space Station in its revolution around the Earth: effects on psychophysiological responses to affective picture viewing.

    abstract::There is evidence suggesting that exposure to an abnormal magnetic environment may produce psychophysiological effects related to abnormalities in responses to stress. This may be of relevance for space medicine where astronauts are exposed to a magnetic field different from that exerted by the Earth. Aim of this stud...

    journal_title:Neuroscience letters

    pub_type: 杂志文章,随机对照试验


    authors: Del Seppia C,Mezzasalma L,Messerotti M,Cordelli A,Ghione S

    更新日期:2006-06-12 00:00:00

  • Developmentally regulated induction of neurite outgrowth from immature chick sensory neurons (DRG) by homogenates of avian or mammalian heart, liver and brain.

    abstract::Neurite outgrowth is elicited from whole explants or dissociated neurons of 8--10-day-old chick embryo sensory, dorsal root ganglia when cultured in the presence of a high speed supernatant fraction (105,000 g) from homogenates of chick or rat heart, liver or brain. The neurite promoting activity is not identical to m...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lindsay RM,Tarbit J

    更新日期:1979-05-01 00:00:00

  • Investigations of the discriminative properties of the frog's olfactory mucosa using a photoactivable odorant.

    abstract::The photoactivable compound phenylazide interacts reversibly with the frog's olfactory epithelium when delivered as an olfactory stimulus. Its application together with UV irradiation resulted in a differential reduction of the responses (electro-olfactogram) to several odorants. It was found that this chemical modifi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Delaleu JC,Holley A

    更新日期:1983-06-30 00:00:00