H2O2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin.

abstract：:Spontaneous gasps were recorded in pentobarbitone-anesthetized adult cats. Mean interval between gasps in 11 cats with their buffer nerves intact was of 65 sec; it was significantly prolonged to 174 sec after unilateral carotid neurotomy and to 403 sec after bilateral carotid neurotomy. Additional sectioning of both a...

journal_title：Neuroscience letters

authors： Zuazo A,Zapata P

更新日期：1980-01-01 00:00:00

abstract：:The commonly used benzidine derivatives such as diaminobenzidine, o-dianisidine and benzidine dihydrochloride are apparently carcinogenic. Available information, however, indicates that tetramethyl benzidine (TMB) is safer in this regard, and we have therefore developed a procedure in which TMB is used as a substrate ...

journal_title：Neuroscience letters

authors： Hardy H,Heimer L

更新日期：1977-08-01 00:00:00

abstract：:The muscarinic receptor antagonist scopolamine significantly increased the number of errors in the working memory task with a three-panel runway setup, when injected bilaterally at 3.2 micrograms/side into the dorsal hippocampus. The increase in working memory errors induced by intrahippocampal 3.2 micrograms/side sco...

journal_title：Neuroscience letters

authors： Ohno M,Kishi A,Watanabe S

更新日期：1996-10-11 00:00:00

abstract：:Since calcium homeostasis is altered in cultured skin fibroblasts from aged and Alzheimer donors, the present study examined the degradation of spectrin, a substrate of the calcium dependent protease calpain. Spectrin proteolysis was estimated as the percentage of spectrin breakdown products (e.g., 150 + 155 kDa bands...

journal_title：Neuroscience letters

authors： Peterson C,Vanderklish P,Seubert P,Cotman C,Lynch G

更新日期：1991-01-02 00:00:00

abstract：:The levels of immunoreactive Leu-enkephalin (ir-Leu-Enk) were measured in acid extract of hearts and lungs of adult normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Heart contents in ir-Leu-Enk were significantly higher in SHR rats (2.67 pmol/g) than in WKY rats (1.5 pmol/g). However, no sign...

journal_title：Neuroscience letters

authors： Dumont M,Lemaire S

更新日期：1988-11-22 00:00:00

abstract：:Both backward masking and transcranial magnetic stimulation (TMS) are capable of hindering perception of a visual target. To study the relationship between these two methods we applied TMS over the occipital pole in combination with the visual backward masking technique shine-through. The recently discovered weak shin...

journal_title：Neuroscience letters

authors： Kammer T,Scharnowski F,Herzog MH

更新日期：2003-06-12 00:00:00

abstract：:The gamma aminobutyric acid (GABA) system has been implicated in the susceptibility to develop alcohol dependence and in determining electroencephalogram (EEG) beta activity. The role of the GABA receptor alpha-2 gene (GABRA2) in human alcohol dependence was determined in a genetic and electrophysiological study. The ...

journal_title：Neuroscience letters

authors： Lydall GJ,Saini J,Ruparelia K,Montagnese S,McQuillin A,Guerrini I,Rao H,Reynolds G,Ball D,Smith I,Thomson AD,Morgan MY,Gurling HM

更新日期：2011-08-18 00:00:00

abstract：:An increase in the arthritis index as a marker of chronic inflammation and suppression of food intake are observed in adjuvant arthritic (AA) rats. Our previous study demonstrated that central oxytocin (OXT)-ergic pathways were activated potently in AA rats. In the present study, OXT-saporin (SAP) cytotoxin, which che...

journal_title：Neuroscience letters

authors： Matsuura T,Kawasaki M,Hashimoto H,Yoshimura M,Motojima Y,Saito R,Ueno H,Maruyama T,Sabanai K,Mori T,Ohnishi H,Sakai A,Ueta Y

更新日期：2016-05-16 00:00:00

abstract：:Stimulation of type-1 astrocytes, by a number of agonists, has been shown to increase cytosolic Ca2+ concentrations in an oscillatory manner. However, it is unknown how these are driven or altered by aging, injury or disease. Therefore, we characterized the signaling properties of rat type-1 astrocytes in monolayer cu...

journal_title：Neuroscience letters

authors： Johnston JM,Burnett P,Thomas AP,Tezapsidis N

更新日期：2006-03-06 00:00:00

abstract：:To clarify the possible involvement of protein kinase (PK) C activation in the excitation and sensitization of polymodal receptors (PMRs), the effects of phorbol 12,13-dibutyrate (PDBu) on PMRs were studied in canine testis-spermatic nerve preparations in vitro. Application of PDBu (10(-7), 10(-6), AND 10(-5) M) for 5...

journal_title：Neuroscience letters

authors： Leng S,Mizumura K,Koda H,Kumazawa T

更新日期：1996-03-08 00:00:00

abstract：:We have investigated whether administration of staurosporine, which has been reported to induce differentiation in the human neuroblastoma cell in vitro, attenuates amnesia induced by basal forebrain lesion in rats. Multiple dosage of staurosporine at the doses of 0.05 and 0.1 mg/kg (i.p.) attenuated the impaired perf...

journal_title：Neuroscience letters

authors： Nabeshima T,Ogawa S,Nishimura H,Fuji K,Kameyama T,Sasaki Y

更新日期：1991-01-14 00:00:00

abstract：:A trait locus for electroencephalographic photoparoxysmal response (PPR) has been mapped to the chromosomal region 6p21 near a susceptibility locus for juvenile myoclonic epilepsy (JME). Linkage disequilibrium mapping revealed strong associations between JME and polymorphisms of the gene encoding the bromodomain-conta...

journal_title：Neuroscience letters

authors： Lorenz S,Taylor KP,Gehrmann A,Becker T,Muhle H,Gresch M,Tauer U,Sander T,Stephani U

更新日期：2006-05-29 00:00:00

abstract：:Numerous studies have provided evidence that physical activity promotes cortical plasticity in the adult brain and in turn facilitates learning. However, until now, the effect of simultaneous physical activity (e.g. bicycling) on learning performance has not been investigated systematically. The current study aims at ...

journal_title：Neuroscience letters

authors： Schmidt-Kassow M,Kulka A,Gunter TC,Rothermich K,Kotz SA

更新日期：2010-09-20 00:00:00

abstract：:The effect of apamin on learning was examined using two behavioral tasks where the animals were subjected to two trials separated by a 24h interval. In the Y maze task, apamin administered before the acquisition session did not enhance performance on both the acquisition session and the restitution session. In the sec...

journal_title：Neuroscience letters

authors： Deschaux O,Bizot JC

更新日期：2005-09-23 00:00:00

abstract：:Following peripheral nerve section, the cell body and proximal axon undergo various physiological and morphological changes which may be associated with regrowth. We found that axotomy reduced the amplitude and duration of the afterhyperpolarization (AHP) of the action potential (AP) of bullfrog sympathetic neurones. ...

journal_title：Neuroscience letters

authors： Kelly ME,Gordon T,Shapiro J,Smith PA

更新日期：1986-06-18 00:00:00

abstract：:The intracellular stress-induced proteins provide protection against toxic insults. Here, a 60,000-Da heat shock 60 (hsp60)-like protein was detected, with five different antibodies, in conditioned media derived from rat cortical astrocytes and a human neuroblastoma cell line. Extracellular neuroblastoma hsp60-like im...

journal_title：Neuroscience letters

authors： Bassan M,Zamostiano R,Giladi E,Davidson A,Wollman Y,Pitman J,Hauser J,Brenneman DE,Gozes I

更新日期：1998-06-26 00:00:00

abstract：:Brachial plexus avulsion (BPA) is one of the major injuries in motor vehicle accidents and may result in neuropathic pain. Accumulating evidence suggests that 30-80% of BPA developed neuropathic pain in human. In our study, complete brachial plexus avulsion (C5-T1) rats model leads to the results that 37.5% of rats ha...

journal_title：Neuroscience letters

authors： Wang L,Yuzhou L,Yingjie Z,Jie L,Xin Z

更新日期：2015-03-04 00:00:00

abstract：:The present study seeked to determine whether the neurodegenerative and cognitive alterations in aged apolipoprotein E-deficient mice are differentially reversed by transgenic overexpression of human apolipoprotein-E3 vs. apolipoprotein-E4 in the background of deficient endogenous apolipoprotein E. These studies showe...

journal_title：Neuroscience letters

authors： Veinbergs I,Mallory M,Mante M,Rockenstein E,Gilbert JR,Masliah E

更新日期：1999-04-23 00:00:00

abstract：:Estrogen was shown to promote neuronal survival against several neurotoxic insults including β-amyloid (Aβ). The proposed mechanism includes the activation of the mitogen activated protein kinase/extracellular signal-regulated kinase (Mapk/Erk), phosphatidylinositol 3-kinase/Akt pathways and the upregulation of antiap...

journal_title：Neuroscience letters

authors： Mateos L,Persson T,Katoozi S,Gil-Bea FJ,Cedazo-Minguez A

更新日期：2012-01-11 00:00:00

abstract：:Associations between PIN1 gene polymorphisms and Alzheimer's disease (AD) risk remain controversial, possibly because single studies often lack sufficient statistical power. In this study, we performed a meta-analysis to evaluate the association of two commonly studied PIN1 polymorphisms, -842G/C and -667T/C, with the...

journal_title：Neuroscience letters

authors： Cao L,Wang F,Ge H,Wu PC,Qu P,Chen GH,Gao ZL

更新日期：2013-02-22 00:00:00

abstract：:The purpose of this study was to examine the effects of intraplantar dexmedetomidine to relieve neuropathic pain and determine the role of peripheral α2-adrenoceptors. Neuropathic pain was induced by ligating the L5 and L6 spinal nerves in male Sprague-Dawley rats, and mechanical allodynia was assessed using von Frey ...

journal_title：Neuroscience letters

authors： Lee HG,Choi JI,Kim YO,Yoon MH

更新日期：2013-12-17 00:00:00

abstract：:Fetal intrauterine growth restriction generates chronic hypoxia due to placental insufficiency. Despite the hemodynamic process of blood flow, redistributions are taking place in key organs such as the fetal brain during intrauterine growth restriction, in order to maintain oxygen and nutrients supply. The risk of sho...

journal_title：Neuroscience letters

authors： Hernández-Andrade E,Cortés-Camberos AJ,Díaz NF,Flores-Herrera H,García-López G,González-Jiménez M,Santamaría A,Molina-Hernández A

更新日期：2015-01-01 00:00:00

abstract：:The present study shows that cultured fibroblasts from sporadic Alzheimer's disease patients are deficient in protein kinase C-regulated secretion of amyloid precursor protein. In particular, Alzheimer fibroblasts show a reduced basal secretion and a reduced response at low concentrations of phorbol-12,13-dibutyrate, ...

journal_title：Neuroscience letters

authors： Bergamaschi S,Binetti G,Govoni S,Wetsel WC,Battaini F,Trabucchi M,Bianchetti A,Racchi M

更新日期：1995-12-01 00:00:00

abstract：:Parkinson's disease is due to a dopamine deficiency caused by the degeneration of midbrain dopamine neurons. Current therapies are aimed to substitute dopamine or to directly stimulate postsynaptic dopamine receptors. However, not all patients profit from current therapies to the same extent, even serious side effects...

journal_title：Neuroscience letters

authors： Schmidt WJ,Mayerhofer A,Meyer A,Kovar KA

更新日期：2002-09-27 00:00:00

abstract：:The distribution of cells concentrating R 5020, a potent synthetic progestin, in the brain and pituitary of estrogen-primed ovariectomized rat was investigated by radioautography. In the brain, radioactivity was found concentrated in nuclei of neurons in the preoptic region (nucleus (n.) preopticus pars suprachiasmati...

journal_title：Neuroscience letters

authors： Warembourg M

更新日期：1978-10-01 00:00:00

abstract：:We have conjectured that axons embody a post transcriptional sprouting programme repressed by mature Schwann cells. Injured nerves of Wld(s) mice neither degenerate nor regenerate for several weeks but axons do regrow if the resident cells of the distal stump are destroyed. To test our hypothesis we made an extended c...

journal_title：Neuroscience letters

authors： Iñiguez A,Alvarez J

更新日期：1999-06-18 00:00:00

abstract：:Increased expression of tumor necrosis factor alpha (TNFalpha) has been shown in adult stroke models. However, its expression and relationship with neuronal apoptosis in neonatal rats with transient middle cerebral artery occlusion (MCAO) have not been clearly elucidated. We studied the expression and distribution of ...

journal_title：Neuroscience letters

authors： Mao M,Hua Y,Jiang X,Li L,Zhang L,Mu D

更新日期：2006-08-07 00:00:00

abstract：:After short periods of intense sympathetic activation, the action of the vagus nerve on heart rate is inhibited for periods of many minutes to several hours. This effect is not abolished by effective blockade of alpha- or beta-adrenoceptors and is not duplicated by administration of noradrenaline or isoprenaline. A si...

journal_title：Neuroscience letters

authors： Potter EK

更新日期：1985-03-15 00:00:00

abstract：:The medial prefrontal cortex (mPFC) is thought to exert inhibitory control over stress-induced activation of the amygdala and neurocognitive effects. As evidence to support this, we examined how exposure to either a brief or prolonged stress affected on amygdalar c-Fos levels and recognition memory of animals with mPF...

journal_title：Neuroscience letters

authors： Park JC,Jeon YJ,Kim JJ,Cho J,Choi DH,Han JS

更新日期：2020-09-14 00:00:00

abstract：:Painful and non-painful phantom phenomena occur frequently after amputations but are rarely investigated in the perioperative stage. The goal of the present study was the assessment of phantom phenomena, pain and changes in primary somatosensory cortex prior to and after upper limb amputation. Two patients who suffere...

journal_title：Neuroscience letters

authors： Grüsser SM,Winter C,Schaefer M,Fritzsche K,Benhidjeb T,Tunn P,Schlag PM,Flor H

更新日期：2001-04-13 00:00:00