H2O2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatonin.

Abstract:

:Melatonin protection against H2O2-induced lipid peroxidation in brain homogenates was measured in vitro. The level of malonaldehyde (MDA) plus 4-hydroxyalkenals (4-HDA) was assayed in brain homogenates as an index of induced membrane oxidative damage. Brain homogenates were co-incubated with H2O2 alone or in combination with melatonin. Brain MDA + 4-HDA increased after H2O2 (0.1-5 mM) with the effect being both concentration- and time-dependent. Melatonin (0.1-5 mM) protected against H2O2-induced lipid peroxidation of brain homogenates in a concentration-dependent manner.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Sewerynek E,Poeggeler B,Melchiorri D,Reiter RJ

doi

10.1016/0304-3940(95)11803-5

subject

Has Abstract

pub_date

1995-08-11 00:00:00

pages

203-5

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304394095118035

journal_volume

195

pub_type

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