Abstract：
:Tonsils have a privileged situation in the immune system in that they are in touch with the environment. Melatonin is a hormone that is influenced by the circadian environmental variations of dark-light and is a modulator of the immune system. We have studied a group of thirty five children with recurrent acute tonsillitis that were submitted for tonsillectomy. Tonsillar lymphocyte subsets were determined before and after culture through flow cytometry in a tonsillar mononuclear suspension. After the culture, the lymphocyte subsets of type B suffered a decrease that was restored in the presence of melatonin or phytohemaglutinin, and even increased above the values of the control when the culture was accomplished in the presence of both substances. This process was specific for B cells, no occurrence for T lymphocytes or natural killer cells. Melatonin is found in the crossroads of the interaction of the microorganisms, pollens or inert substances with the tonsillar lymphocytes in the production of the immune defences. Further study is required on tonsillar pathology to explain its physiopathology and its possible therapeutic role.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lopez-Gonzalez MA,Guerrero JM,Sanchez B,Delgado Fdoi
10.1016/s0304-3940(98)00292-4subject
Has Abstractpub_date
1998-05-15 00:00:00pages
131-4issue
2-3eissn
0304-3940issn
1872-7972pii
S0304-3940(98)00292-4journal_volume
247pub_type
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