Effects of caloric restriction on cognition and behavior in developing mice.

abstract：:Serotonin transporter (5-HTT) is a key component of the serotonergic neurotransmitter system. Few studies have focused on polymorphisms of the serotonin transporter and antipsychotic response and, in particular, there have so far been no published studies on the association between the serotonin transporter and respon...

journal_title：Neuroscience letters

authors： Wang L,Yu L,He G,Zhang J,Zhang AP,Du J,Tang RQ,Zhao XZ,Ma J,Xuan JK,Xiao Y,Gu NF,Feng GY,Xu MQ,Xing QH,He L

更新日期：2007-02-27 00:00:00

abstract：:A remarkable candidate gene for late-onset Alzheimer's disease (AD) is 24-dehydrocholesterol reductase (DHCR24) gene that encodes seladin-1 (selective AD indicator), an enzyme that is involved in the cholesterol biosynthetic pathway, exerts neuroprotective and anti-apoptotic effects, and found to be down regulated in ...

journal_title：Neuroscience letters

authors： Fehér A,Juhász A,Pákáski M,Kálmán J,Janka Z

更新日期：2012-09-20 00:00:00

abstract：:PC12 cells, a clonal cell line established from a rat pheochromocytoma, were injected into the subarachnoid space in the lumbar spinal cord of adult rats. These cells invaded the spinal cord as a metastatic tumor and, after 2 weeks, displaced one-third of the cord parenchyma, causing hind limb paralysis. The tumor con...

journal_title：Neuroscience letters

authors： Pappas GD,Sagen J

更新日期：1986-09-25 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoconstrictor that causes hypoperfusion of the neurosensory retina. We investigated immunohistochemically the expression of the receptors for ET-1, ET(A) and ET(B), in control and locally detached retinas of the pig. Immunoreactivity for ET(A) was expressed in the innermost retinal la...

journal_title：Neuroscience letters

authors： Iandiev I,Uhlmann S,Pietsch UC,Biedermann B,Reichenbach A,Wiedemann P,Bringmann A

更新日期：2005-08-12 00:00:00

abstract：:Nitric oxide (NO) exerts cytotoxic effects on various cells including neuronal cells. Glial NO production, mediated via induction of inducible NO synthase (iNOS), enhances neurotoxicity associated with the N-methyl-D-aspartate (NMDA) receptor. The present study examined whether nicotinamide, an inhibitor of poly (ADP-...

journal_title：Neuroscience letters

authors： Fujimura M,Tominaga T,Yoshimoto T

更新日期：1997-06-06 00:00:00

abstract：:Glucose homeostasis was studied in the spontaneously hypertensive rat (SHR). The fasting plasma glucose levels were similar in the SHR and normotensive Wistar-Kyoto (WKY) rat (102.7+/-2.4 vs. 107.4+/-4.2 mg/dl, P > 0.01). One hour after glucose challenge, the plasma glucose level was slightly but insignificantly incre...

journal_title：Neuroscience letters

authors： Tong YC,Wang CJ,Cheng JT

更新日期：1997-09-19 00:00:00

abstract：:The strict photoperiodic dependence of gonadotropic function observed in mink provides an excellent physiological model for studying the activity of GnRH hypothalamic neurons. In mink, exposure to more than 10 h light inhibits the activity of this neurohormonal system. Melatonin plays an essential role in this type of...

journal_title：Neuroscience letters

authors： Boissin-Agasse L,Barberis C,Audigier S,Roch G,Boissin J

更新日期：1992-09-14 00:00:00

abstract：:Using an animal model of temporal lobe epilepsy, the kainic acid lesioned rat hippocampus, we have evaluated the possibility of modulating glutamate N-methyl-D-aspartate (NMDA) receptor-dependent evoked epileptiform activity through the manipulation of NMDA receptor redox sites. Epileptiform activity was recorded extr...

journal_title：Neuroscience letters

authors： Quesada O,Hirsch J,Ben-Ari Y,Bernard C

更新日期：1996-07-19 00:00:00

abstract：:In situ hybridization of mRNAs for beta- and gamma-cytoplasmic non-muscle actin in the mouse central nervous system revealed their differential expression correlating with the developmental stages. Most intense expression of both isoactin mRNAs at the specific postnatal developmental stage was observed in pyramidal ce...

journal_title：Neuroscience letters

authors： Chiba T,Nakamura Y,Sakiyama S

更新日期：1990-04-20 00:00:00

abstract：:Repeated exposure to dizocilpine (MK-801) can be used as a model of schizophrenia that incorporates disease progression. Proton magnetic resonance spectroscopy (1H MRS) has been widely used to investigate schizophrenia-related alterations in glutamate (Glu). The purpose of this study was to investigate metabolic alter...

journal_title：Neuroscience letters

authors： Yoo CH,Song KH,Lim SI,Lee DW,Woo DC,Choe BY

更新日期：2017-01-10 00:00:00

abstract：:Parvalbumin-immunoreactive dystrophic neurites and aberrant terminal sprouts associated with senile plaques, together with preserved density of parvalbumin-immunoreactive neurons, were found in the cerebral cortex of two patients with Alzheimer's disease, one of them familiar, in which a biopsy of the left frontal lob...

journal_title：Neuroscience letters

authors： Ferrer I,Zújar MJ,Rivera R,Soria M,Vidal A,Casas R

更新日期：1993-08-20 00:00:00

abstract：:The effect of antagonists on N-methyl-D-aspartate (NMDA)-induced response was investigated in isolated nucleus tractus solitarii (NTS) neurons freshly isolated from the rat using a conventional pathclamp technique. The NMDA-induced inward current consisted of an initial peak followed by a steady-state component. The c...

journal_title：Neuroscience letters

authors： Nakagawa T,Shirasaki T,Tateishi N,Murase K,Akaike N

更新日期：1990-05-31 00:00:00

abstract：:Several lines of evidence suggest that dopamine exerts a chronic inhibitory action on GABAergic cells in the striatum, and striatal glutamic acid decarboxylase (GAD) mRNA levels are increased after ipsilateral dopaminergic denervation. In the present study we have used GAD immunocytochemistry to assess whether dopamin...

journal_title：Neuroscience letters

authors： Segovia J,Armstrong DM,Benzing WC,Hornby PJ

更新日期：1991-01-28 00:00:00

abstract：:This experiment has been designed to evaluate the basal serum BDNF level and memory performance, and also the change in BDNF in response to acute aerobic and anaerobic training in athletes and sedentary groups. Nineteen middle aged elite athletes (45-65 years) who used to be competing at domestic championship for more...

journal_title：Neuroscience letters

authors： Babaei P,Damirchi A,Mehdipoor M,Tehrani BS

更新日期：2014-04-30 00:00:00

abstract：:Several studies on the relationship between event-related desynchronization/synchronization (ERD/ERS) and cognitive performance revealed contradictory results particularly for the alpha band. Studies from our laboratory have shown that good performers show a larger upper alpha ERD (interpreted in terms of larger corti...

journal_title：Neuroscience letters

authors： Doppelmayr M,Klimesch W,Sauseng P,Hödlmoser K,Stadler W,Hanslmayr S

更新日期：2005-06-24 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1), an insulinotropic peptide secreted from enteroendocrine cells, has been known to have a neuroprotective effect. However, it is not fully understood the intracellular mediator of GLP-1 signaling in neuronal cells. In the present study, we examined the change in intracellular signaling o...

journal_title：Neuroscience letters

authors： Nakajima S,Numakawa T,Adachi N,Yoon HS,Odaka H,Ooshima Y,Kunugi H

更新日期：2016-03-11 00:00:00

abstract：:Five animals were used as their own controls for a replication on cats of earlier findings of facilitated paradoxical sleep (PS) after learning. The experiment was based on an instrumental conditioning with positive reinforcement and three-hour recordings of the subsequent sleep. Facilitation was observed as (a) an in...

journal_title：Neuroscience letters

authors： Lecas JC

更新日期：1976-12-01 00:00:00

abstract：:Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required. This study is aimed to investigate if a set of DTNBP1 variations might influence clinic psychotic phenotype or treatment response in a sample of 240 Korean schizophrenic in-patie...

journal_title：Neuroscience letters

authors： Pae CU,Drago A,Kim JJ,Patkar AA,Jun TY,Lee C,Mandelli L,De Ronchi D,Paik IH,Serretti A

更新日期：2008-08-01 00:00:00

abstract：:Opiate withdrawal syndrome is temporally associated with the hyperactivity of locus coeruleus neurons. Previous studies have shown that this hyperactivity, at least in part, results from the activity of excitatory afferents which mainly include the orexinergic neurons of hypothalamus and glutamatergic neurons of parag...

journal_title：Neuroscience letters

authors： Hooshmand B,Azizi H,Javan M,Semnanian S

更新日期：2017-01-01 00:00:00

abstract：:Superfusion of the isolated spinal cord of neonatal rats (4-9 days postpartum) with physiological medium containing 2-chloroadenosine (2-CA) or anoxic medium (equilibrated with 95% N2-5% CO2) depressed the evoked monosynaptic reflex (MSR) recorded extracellularly from a ventral spinal root. The effectiveness of 2-CA o...

journal_title：Neuroscience letters

authors： Lloyd HG,Perkins A,Spence I

更新日期：1989-06-19 00:00:00

abstract：:Experimental Scrapie in hamster is a simple, reproducible model of prion diseases that occur in humans and animals. Stereotaxic microinoculation (0.5 microliter) of the agent (263 K) into a specific cerebral structure (striatum) in hamster, previously developed in our group, gives the opportunity to further investigat...

journal_title：Neuroscience letters

authors： Grégoire N,Lebrun F,Fahn L,Salamon G,Nicoli J

更新日期：1993-12-12 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a devastating and fatal neurodegenerative disease affecting approximately 30,000 individuals in the United States. The average age of onset is 55 years and progression of the disease is rapid with most patients dying of respiratory failure within 3-5 years. Currently available th...

journal_title：Neuroscience letters

authors： St Martin JL,Wang L,Kaprielian Z

更新日期：2020-01-18 00:00:00

abstract：:The content of the neurosteroids, dehydroepiandrosterone (DHEA) in the brain decreases with aging. Also the oxidative energy metabolism is known to decrease with aging. Hence we examined the effects of treatment with DHEA (0.2 or 1.0 mg/kg body weight for 7 days) on oxidative energy metabolism in brain mitochondria fr...

journal_title：Neuroscience letters

authors： Patel MA,Katyare SS

更新日期：2006-07-10 00:00:00

abstract：:1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) kills tumor cells via multiple actions including alkylation and carbamoylation. Previously, we have reported that formation of S-nitrosoglutathione (GSNO) in glioma cells overexpressing inducible nitric oxide synthase (iNOS) contributed to nitric oxide (NO)-dependent carbamo...

journal_title：Neuroscience letters

authors： Yang JJ,Yin JH,Yang DI

更新日期：2007-05-11 00:00:00

abstract：:Previous studies have extensively reported an advantage of females in empathy as compared with males. It remains to be clarified, however, whether these sex differences are associated with sex specific neural processes underlying empathic response to different intensity of emotional stimulus. The present study examine...

journal_title：Neuroscience letters

authors： Luo P,Zheng X,Chen X,Li Y,Wang J,Deng L,Zheng X

更新日期：2014-08-22 00:00:00

abstract：:The mechanism of action of the 'geste antagonistique', or sensory trick, used by patients with dystonic blepharospasm (BSP) to transiently diminish their symptoms is presently unknown. In this paper we examined the effects induced by a sensory trick consisting of finger contact with the face on the electrically induce...

journal_title：Neuroscience letters

authors： Gómez-Wong E,Martí MJ,Cossu G,Fabregat N,Tolosa ES,Valls-Solé J

更新日期：1998-07-24 00:00:00

abstract：:Single-site variants in the calmodulin-binding domain of RC3/neurogranin were heterologously expressed in Xenopus oocytes to examine their effects on serotonin-evoked currents. RC3 variants serine36 -->alanine (Ser36-->Ala), serine36-->glycine (Ser36-->Gly), and phenylalanine37-->tryptophan (Phe37-->Trp), which bind c...

journal_title：Neuroscience letters

authors： Watson JB,Margulies JE,Coulter PM 2nd,Gerendasy DD,Sutcliffe JG,Cohen RW

更新日期：1996-11-29 00:00:00

abstract：:Complement is implicated in the pathology of neurodegenerative and inflammatory disease in the central nervous system (CNS). Although studies demonstrate that inhibition of complement activation attenuates disease development in the CNS, the specific complement components that contribute to the pathogenesis of CNS dis...

journal_title：Neuroscience letters

authors： Reiman R,Campos Torres A,Martin BK,Ting JP,Campbell IL,Barnum SR

更新日期：2005-12-30 00:00:00

abstract：:Acute stress can provoke apoptosis of the retina cells, and up-regulation of calcitonin gene related peptide (CGRP) in retina. However the role of CGRP in the pathology of the stress induced apoptosis of the retina cells is still elusive. The aim of this study was to investigate the endogenous of CGRP on retinal cell ...

journal_title：Neuroscience letters

authors： Yang JH,Zhang YQ,Guo Z

更新日期：2011-08-26 00:00:00

abstract：:Vigabatrin (VGB, gamma-vinyl-gamma-aminobutyric acid (GABA)), an irreversible inhibitor of GABA transaminase, increases regional inhibitory effects by elevating GABA concentration and reducing glutamate synthesis. In the present study, changes in glutamate dehydrogenase (GDH) activity and its immunoreactivity in the s...

journal_title：Neuroscience letters

authors： Kang TC,An SJ,Park SK,Hwang IK,Choi SY,Kwon OS,Won MH

更新日期：2003-04-10 00:00:00