Abstract：
:Following the i.c.v. administration of antivasopressin serum the alpha-MPT-induced disappearance of noradrenaline was decreased in the dorsal septal nucleus, parafascicular nucleus and the rostral part of the nucleus tractus solitarii, whereas that of dopamine was lowered in the caudate nucleus and in the A2 region of the medulla oblongata. In general the effects are opposite to those previously found following the i.c.v. administration of vasopressin. The results support the hypothesis that vasopressin modulates catecholamine neurotransmission in specific brain regions of the rat.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Versteeg DH,De Kloet ER,Greidanus TV,De Wied Ddoi
10.1016/0304-3940(79)90058-2subject
Has Abstractpub_date
1979-01-01 00:00:00pages
69-73issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(79)90058-2journal_volume
11pub_type
杂志文章abstract：:Pharmacological agents acting at alpha-2 adrenergic receptors are widely used in physiology and neuroscience research. Mounting evidence of their potential utility in clinical and experimental psychopharmacology, necessitates new models and novel model organisms for their screening. Here, we characterize behavioral ef...
journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2019.03.001
更新日期：2019-05-14 00:00:00
abstract：:We characterized muscarnic and purinergic receptors and urodynamic parameters in the bladder of cyclophosphamide (CYP)-treated rats to clarify the mechanisms involved in the pathophysiology of interstitial cystitis (IC). In the cystometry of CYP-treated rats compared with control rats, the micturition interval and mic...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.02.065
更新日期：2008-05-02 00:00:00
abstract：:(1) This study shows the effects of bicuculline pretreatment on the GABAergic system in certain areas of the rat brain after acute ether and cold stress. (2) The spontaneous locomotor activity was diminished by either ether stress or cold stress or bicuculline. (3) Acute ether stress enhanced GABA concentration in the...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90863-x
更新日期：1994-07-18 00:00:00
abstract：:We studied the influence of caffeine treatment (50 mg/kg for 3 doses) on catecholamine utilization and adrenergic receptor binding in female rats. Caffeine enhanced the reduction in forebrain norepinephrine levels following alpha-methyl-p-tyrosine without altering the reduction in dopamine levels. Caffeine reduced the...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(82)90052-0
更新日期：1982-07-20 00:00:00
abstract：:Throughout life, new neurons are continuously generated from subventricular zone and added to the olfactory bulb (OB). Because a subset of mature OB neurons undergoes spontaneous cell death, adult OB neurogenesis serves for the replacement of this cell loss. Spontaneous cell turnover should alter the neuronal circuits...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.05.017
更新日期：2013-08-26 00:00:00
abstract：:Cerebral perfusion is important in older adults as it is linked to cognitive declines. Physical activity can improve blood flow in the body but little is known about the relationship between physical activity and cerebral perfusion in older adults. In particular, no study has investigated the relation between strength...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.12.011
更新日期：2014-02-07 00:00:00
abstract：:Granule neurons from the rat dentate gyrus were acutely isolated and whole-cell currents recorded. Maximal enhancement of 7 microM gamma-aminobutyric acid (GABA; EC30) evoked currents was obtained with 100 microM pentobarbital where the peak-current was 2.1+/-0.2 of control. One hundred microM pentobarbital alone evok...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.09.025
更新日期：2003-12-19 00:00:00
abstract：:The effect of the neuropeptide, substance P, on the transport of D-[(3)H]aspartate into rat striatal synaptosomes was studied. Almost 90% of the total transport of D-[(3)H]aspartate was sodium-dependent and the maximum rate (V(max)) of this transport was increased by 34% of control by 2.5 nM substance P (EC(50)=0.52 n...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01318-5
更新日期：2000-08-25 00:00:00
abstract：:Cyclophosphamide (CP) has been used as an antitumour agent or immunosuppressant clinically, though the potential biological role of CP in the central nervous system (CNS) has not been clarified. In the present study, we found that pretreatment with CP prevented neuronal cell death caused by serum deprivation in cultur...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.12.073
更新日期：2010-02-12 00:00:00
abstract：:Activated microglia surround degenerating substantia nigra neurons in Parkinson's disease (PD). Such microglia produce high levels of interleukin-1 beta (IL-1 beta) and interleukin-1 alpha (IL-1 alpha). T and C alleles exist for the IL-1 beta-511 regulatory region as well as for the IL-1 alpha-889 regulatory region. T...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)00300-2
更新日期：2002-06-21 00:00:00
abstract：:Benzodiazepine (BZ) recognition sites of the 'peripheral' type were localized autoradiographically in human postmortem brain and kidney using [3H]Ro 5-4864. These sites presented a relatively homogeneous distribution. Areas such as the ependyma, choroid plexus and olfactory bulb, which in the rat are very rich in thes...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(86)90181-3
更新日期：1986-05-15 00:00:00
abstract：:Vitamin B12 is implicated in methylation processes. Myelin basic protein is methylated on one arginine group. A defect in methylation could produce an unstable protein, leading to neurological disorders. In order to study myelin basic protein, we have developed the cultures of newborn rat oligodendrocytes in vitamin B...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01243-x
更新日期：2000-07-21 00:00:00
abstract：:Cerebral ischemia/reperfusion involves inflammatory process and naloxone is able to reduce infarct volume and has been used as a therapeutic agent for brain injury. Hypoxia induces the immediate early genes (IEGs) rapidly and transiently that may initiate a cascade of cellular responses that are necessary for survival...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.04.036
更新日期：2008-06-20 00:00:00
abstract：:Thyrotropin releasing hormone (TRH) was applied iontophoretically to single neruones in the rat bulbar reticular formation. TRH excited 41 to 56 cells tested; none were inhibited. Excitation developed slowly and was prolonged, and desensitization often occurred. TRH effects were not correlated with effects of acetylch...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(79)91525-8
更新日期：1979-11-01 00:00:00
abstract：:By the use of light microscopic immunohistochemistry it was shown that a significant population of small primary sensory afferents of guinea pig contains immunoreactivities to antisera directed against prodynorphin-opioid peptides, whereas immunoreactivities to antisera directed against opioid peptides exclusively con...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90079-5
更新日期：1985-08-05 00:00:00
abstract：:Traumatic brain injury (TBI) is a major cause of neurological disability across all ages, but the elderly are particularly vulnerable and have a worse prognosis than younger individuals. To advance the understanding of long-term pathogenesis induced by TBI in the elderly, aged mice (21 -- 24 months) were given a contr...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.01.049
更新日期：2009-03-13 00:00:00
abstract：:The cytokine interleukin-6 (IL-6) may be a contributing mediator of CNS injury in several neurological disorders. To investigate the role of IL-6 in memory-related disorders, we examined transgenic mice (GFAP-IL6) with cerebral overexpression of IL-6 using paired-pulse facilitation, paired-pulse inhibition, and long-t...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)11976-4
更新日期：1995-09-29 00:00:00
abstract：:In an attempt to understand the changes of circulating neuropeptide Y (NPY) during hypoxia, the plasma level of NPY was investigated by radioimmunoassay. Exposure of rats to hypobaric hypoxia at an altitude of 18,000 ft for 4 weeks causes an increase of pulmonary pressure and an elevation of plasma NPY-like immunoreac...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90105-g
更新日期：1992-06-22 00:00:00
abstract：:Actions of the polyamines spermine and spermidine on NMDA-induced currents were examined in cultured hippocampal neurons from embryonic rat. In whole-cell patch experiments using voltage-clamp, spermine (300 microM) produced about a two-fold potentiation of responses to NMDA (at -70 mV in the presence of saturating gl...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90495-7
更新日期：1993-04-02 00:00:00
abstract：:Recent studies have suggested the involvement of some metabolic hormones in memory formation and synaptic plasticity. Insulin dysfunction is known as an essential process in the pathogenesis of sporadic Alzheimer's disease (AD). In this study we examined whether adiponectin (ADN), as an insulin-sensitizing adipokine, ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.10.042
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Genetic factors may play important roles in the pathogenesis of Parkinson's disease, and more than 40 loci involved in Parkinson's disease have been identified. Due to differing allele frequencies across origins, the associations of these loci and sporadic Parkinson's disease in the Eastern Chinese populatio...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2020.135261
更新日期：2020-09-14 00:00:00
abstract：:Argiotoxin636, a component of the spider venom of argiope species, was chemically synthesized together with a number of derivatives in order to analyse their blocking activity on mammalian glutamate receptors. Xenopus laevis oocytes injected with rat brain mRNA served as assay system. The results showed that argiotoxi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90298-8
更新日期：1991-11-11 00:00:00
abstract：:Single units have been recorded extracellularly from the periaqueductal central grey and from adjacent structures in behaving rats during tail flick reflexes elicited by controlled radiant heat. Together with the spike recordings, the heart rate of the animal and a thoracic myogram as an indicator of overall motor act...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(82)90016-7
更新日期：1982-05-17 00:00:00
abstract：:The N-Methyl-D-Aspartate Receptors (NMDARs) are heteromeric cation channels involved in learning, memory, and synaptic plasticity, and their dysregulation leads to various neurodegenerative disorders. Recent evidence has shown that apart from the GluN1/GluN2A and GluN1/GluN2B diheteromeric ion channels, the NMDAR also...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.02.032
更新日期：2016-03-23 00:00:00
abstract：:Early intervention following combat deployment has the potential to prevent posttraumatic stress disorder (PTSD), but there is a need for greater understanding of the factors that contribute to PTSD symptom progression. This study investigated: (1) fear-potentiated startle during a fear extinction, (2) white matter mi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.02.041
更新日期：2016-04-08 00:00:00
abstract：:The levels of apoptosis associated proteins Bcl(2), Bax, cytochrome-c and p53 was investigated in mice cerebral cortex and cerebellum, using an experimental model of fatal murine cerebral malaria (FMCM). Owing to the activation of events central to mitochondrial dysfunctions, we monitored the structural integrity of m...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)00470-6
更新日期：2002-09-06 00:00:00
abstract：:Recent findings from our and other laboratories indicate that cell cycle-related phenomena may play a key role in the formation of Alzheimer-type pathology and neuronal cell death in both Alzheimer's and cerebro-vascular diseases. In this study we examine the expression patterns of cyclins A, B1, D1 and E in neuronal ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00509-1
更新日期：1999-08-13 00:00:00
abstract：:Nociceptin/orphanin FQ (N/OFQ) is an endogenous peptide agonist for the opioid receptor homolog, N/OFQ receptor, and serves for the central control of autonomic functions. Morphological details including the cell types that may account for such N/OFQ functions, however, remain unclear. By using X-gal histochemistry fo...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)01186-2
更新日期：2003-01-02 00:00:00
abstract：:The sexual axis of rats can be rendered photoresponsive by testosterone implants. We have studied in these conditions whether rat pars tuberalis (PT) melatonin receptor density would be decreased after exposure to short photoperiod (SP) like as observed in long day seasonal breeders. The answer is no, but we observed ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12903-7
更新日期：1996-08-16 00:00:00
abstract：:A paired-pulse stimulus protocol was used to measure angular bundle to dentate gyrus paired-pulse inhibition in rats before and after the occurrence of 36 or 72 seizures elicited from the contralateral CA3 region. The seizures showed progressive lengthening. There was a moderate increase in paired-pulse depression 1 h...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90017-7
更新日期：1989-10-23 00:00:00
