Abstract：
:Thyrotropin releasing hormone (TRH) was applied iontophoretically to single neruones in the rat bulbar reticular formation. TRH excited 41 to 56 cells tested; none were inhibited. Excitation developed slowly and was prolonged, and desensitization often occurred. TRH effects were not correlated with effects of acetylcholine, noradrenaline, dopamine or serotonin on the same cells. Atropine applied to cells affected by both acetylcholine and TRH did not affect TRH responses although the acetylcholine actions were blocked. The results support a transmitter role for TRH in this brain area and may explain certain arousal effects of TRH mediated via the reticular formation.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Briggs Idoi
10.1016/0304-3940(79)91525-8keywords:
subject
Has Abstractpub_date
1979-11-01 00:00:00pages
33-6issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(79)91525-8journal_volume
15pub_type
杂志文章abstract：:Parkinson's disease (PD) is characterized by bradykinesia, resting tremor, rigidity and postural instability as well as early symptoms. Previous studies that evaluated the association between H1/H2 MAPT haplotype and PD were mostly conducted in European populations in which the H1 haplotype was a reported risk factor ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.10.029
更新日期：2019-01-18 00:00:00
abstract：:The effect of the R(-) and S(+) isomers of 3,4-methylenedioxyamphetamine (MDA) and its N-methyl analog 3,4-methylenedioxymethamphetamine (MDMA) on [3H]inositol monophosphate accumulation was studied in cells expressing either 5-HT2A or 5-HT2C receptors. The isomers of MDA produced a concentration dependent increase in...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90057-4
更新日期：1994-08-15 00:00:00
abstract：:Genetic factors play an important role in Parkinson's disease (PD) and vary from different races. A previous genome-wide association study (GWAS) identified 17 novel risk loci that were associated with PD in Caucasians. Several subsequent studies investigated the association between these loci and PD in Chinese popula...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2020.134867
更新日期：2020-04-23 00:00:00
abstract：:The conversion of α-synuclein from its natively unfolded and α-helical tetrameric forms to an amyloid conformation is central to the emergence of Parkinson's disease. Therefore, prevention of this conversion may offer an effective way of avoiding the onset of this disease or delaying its progress. At different concent...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.02.055
更新日期：2017-03-22 00:00:00
abstract：:Adenosine and AMP (5'-adenosine monophosphate) applied by microiontophoresis produced depression of neuronal firing rates in cerebral cortex. A number of antidepressant drugs including examples which are known not to affect noradrenaline uptake systems, potentiated the depressant purine effects. Noradrenaline response...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(79)90062-4
更新日期：1979-01-01 00:00:00
abstract：:The heptadecapeptide histogranin, synthesized by adrenal chromaffin cells, is implicated in the analgesia produced by transplanting chromaffin cells into the spinal cord, including block of hyperalgesia mediated by NMDA-subtype glutamate receptors. To examine the neurophysiological basis for this analgesia, we applied...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.03.056
更新日期：2007-05-23 00:00:00
abstract：:The interleukin-6 (IL-6) family of cytokines is thought to be involved in the development and regeneration of peripheral nerves; however, their roles in myelination remain unclear. In this study, we examined the effects of IL-6 on the expression of genes for compact myelin proteins using Schwann cell cultures prepared...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.01.061
更新日期：2010-03-19 00:00:00
abstract：:The periaqueductal gray (PAG) is involved in motor activities, such as movements of the neck, back and hind limbs, cardiovascular regulation, micturition, vocalization, and mating behavior, as well as in nociception control. To accomplish these functions the PAG uses information from other parts of the limbic system, ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(97)00714-3
更新日期：1997-11-28 00:00:00
abstract：:Dopamine (DA) neurons in the ventral tegmental area and substantia nigra pars compacta were induced to fire in bursts with application of N-methyl-D-aspartate (NMDA, 20 microM) and apamin (100 nM) while recording intracellularly in the rat brain slice. L-Arginine (300 microM), a substrate for nitric oxide (NO) product...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00737-x
更新日期：1998-10-23 00:00:00
abstract：:Among the techniques used to reduce spatial neglect's symptoms, left neck muscle vibration (NMV) is alluring because it does not require the patient's attentional co-operation. The aim of this study was to determine the type of NMV-associated feedback that induced the most intense and longest-lasting egocentric post-e...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2020.135557
更新日期：2021-01-19 00:00:00
abstract：:Push-pull cannulae were acutely positioned through previously implanted guides in the globus pallidus of unanesthetized freely moving cats and rats. During slow-flow perfusions, enkephalin release was detected in resting conditions and increased more than 3-fold when both 50 mM K+ and 1.8 mM Ca2+ were present in the p...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90360-8
更新日期：1981-06-12 00:00:00
abstract：:Fragile X syndrome (FXS), a disorder caused by a mutation in the FMR1 gene, is often associated with Attention Deficit Hyperactivity Disorder (ADHD). Common treatments for the hyperactivity often seen in ADHD involve the use of stimulants and α2-adrenergic agonists. The Fmr1 knockout (KO) mouse has been found to be a ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.11.035
更新日期：2015-01-12 00:00:00
abstract：:Rat pineal glands incubated in vitro with 10 or 100 microM norepinephrine (NE) released 51% and 415% more prostaglandin E2 (PGE2) to the medium than in the absence of NE. Phentolamine (10 microM) prevented fully the effect of NE at both concentrations, whereas propranolol failed to affect it significantly. After super...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(82)90038-6
更新日期：1982-08-31 00:00:00
abstract：:We raised polyclonal antibodies against the C-terminal peptides of protein kinase C (PkC) subspecies alpha, beta 1, beta 2, gamma, delta, epsilon, and zeta and checked their specificity against brain extracts using Western immunoblot analysis. With equal amounts of protein applied to gels PkC subspecies beta 1, delta,...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90619-x
更新日期：1994-04-25 00:00:00
abstract：:The retinohypothalamic tract (RHT) in the Djungarian hamster Phodopus sungorus was studied using anterograde neuronal transport of cholera toxin subunit B (CTB) following unilateral intraocular injection. A major projection terminates bilaterally in the hypothalamic suprachiasmatic nuclei (SCN). In the anterior ventra...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90116-3
更新日期：1994-06-06 00:00:00
abstract：:Glucose metabolism produces lactate and hydrogen ions in an anaerobic environment. Cerebral ischemia or hypoxia is believed to become progressively lactacidemic. Monocarboxylate transporters (MCTs) in endothelial cells are essential for the transport of lactate from the blood into the brain. In addition, it is conside...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2020.135479
更新日期：2021-01-10 00:00:00
abstract：:Distributions of 25 motor axons to 60 intrafusal muscle fibers of 10 poles of monkey spindle were reconstructed from serial 1 micron thick transverse sections of lumbrical muscles. About 44% of motor axons co-innervated two or more types of intrafusal fiber. The (dynamic) bag1 fiber shared motor innervation with the (...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90092-8
更新日期：1985-01-07 00:00:00
abstract：:Most single fibers of the cochlear nerve (CN) in 22 cats exhibited effects of mechanical interaction in one cochlea between two sounds applied binaurally, similarly to results in two cats in which the contralateral CN was transected. In 11 of 189 fibers, the spontaneous and/or the sound-evoked activity was suppressed ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(80)90299-2
更新日期：1980-07-01 00:00:00
abstract：:The simple cerebellar lobule is involved in several neuromotor processes and it is activated during guided exercise. Although guided exercises are essential for motor rehabilitation, the plastic events that occur in the simple cerebellar lobule during motor training remain unknown. In this study, normal adult rats wer...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2011.01.043
更新日期：2011-03-24 00:00:00
abstract：:The role of nitric oxide in cerebral insults remains controversial. While numerous studies have used models of ischaemia and hypoxia, few have examined nitric oxide in the kainate model of excitotoxicity. Kainate (10 mg/kg) was administered to rats via the intraperitoneal (i.p.) route to induce submaximal damage to th...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00372-3
更新日期：1998-06-19 00:00:00
abstract：:Cognitive impairment in Parkinson's disease is accompanied by a marked decrease of cerebrocortical nicotinic receptors. To study the putative site of impaired receptor synthesis, frontal cortices of Parkinson patients with cognitive dysfunction have been screened for the expression of the nicotinic receptor alpha 4 su...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)11367-6
更新日期：1995-03-10 00:00:00
abstract：:In 16 rats, the extensor digitorum longus (EDL) - a fast muscle - was grafted, complete with its innervation, into the bed of the (removed) soleus - a slow muscle. Following the transposition, performed on one side only, EDL recovered and showed the contraction time of the contralateral EDL that served as control. How...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(76)90159-2
更新日期：1976-07-01 00:00:00
abstract：:X-box binding protein 1 (XBP1), a critical gene in the endoplasmic reticulum stress response, is located on chromosome 22q12, which has been linked with bipolar disorders in several studies. Recently, associations have been reported between a polymorphism (-116C --> G) in the promoter region of XBP1, and bipolar disor...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.06.012
更新日期：2004-09-02 00:00:00
abstract：:Whale brains have attracted the attention of neuroscientists but there are only sparse studies on whale glial cells. Here we report on immunolabeling of astrocytes by antibodies to glial fibrillary acidic protein (GFAP) or protein S-100 beta (both by the streptavidin/biotin technique), and labeling of microglial cells...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)91027-8
更新日期：1994-02-14 00:00:00
abstract：:Antibodies directed against a glutamate transporter (GLT-1) purified from rat brain were applied to cryostat sections of rat and macaque monkey retinae. In the brain, GLT-1 expression is found mainly in astrocytes, and therefore it has been suggested that GLT-1 may be a glutamate transporter specific to glial cells. H...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90375-1
更新日期：1994-03-14 00:00:00
abstract：:We assess in mice, the electrophysiological criteria developed in humans and rats in vivo for unmyelinated (C) fibre differentiation into sub-classes, derived from the activity-induced latency increase ("slowing") in response to electrical stimulation during 6 min at 0.25 Hz followed by 3 min at 2 Hz. Fibres are consi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.02.057
更新日期：2015-04-10 00:00:00
abstract：:In untreated patients with Parkinson's disease (PD), the total (free and conjugated) serotonin (5-HT) and dopamine (DA) concentrations in the cerebrospinal fluid decreased significantly. While the 5-HT concentration displayed a non-significant trend of negative correlation with the DA concentration in controls, it had...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90817-5
更新日期：1993-09-03 00:00:00
abstract：:Several studies demonstrated that the overexpression of miR-124 in neural stem cells (NSCs) could lead the NSCs to differentiate into neurons and astrocytes, which may be important for functional recovery in spinal cord injury. The present study attempted to explore the potential repairing effect of the NSCs transfect...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.09.025
更新日期：2012-10-31 00:00:00
abstract：:Several studies have reported the presence of methylphenidate (MPH) in effluents; however, its impacts on aquatic life are not yet well understood. Here, we investigated the effects of acute exposure on endocrine and behavioral stress responses to environmentally relevant concentrations of MPH in zebrafish. We show th...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.04.039
更新日期：2017-05-22 00:00:00
abstract：:The slow Wallerian degeneration protein (WldS), a fusion protein containing amino-terminal E4B and full-length nicotinamide mononucleotide adenylyltransferase 1 (Nmnat1), delays axon degeneration caused by physical damages, toxins and genetic mutations which result in patients being diagnosed with neurodegenerative di...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.09.068
更新日期：2007-01-16 00:00:00
