Antidepressant drugs potentiate suppression by adenosine of neuronal firing in rat cerebral cortex.

Abstract:

:Adenosine and AMP (5'-adenosine monophosphate) applied by microiontophoresis produced depression of neuronal firing rates in cerebral cortex. A number of antidepressant drugs including examples which are known not to affect noradrenaline uptake systems, potentiated the depressant purine effects. Noradrenaline responses were unaffected or reduced. Purines may therefore be important in the mechanism of action of antidepressant drugs.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Stone TW,Taylor DA

doi

10.1016/0304-3940(79)90062-4

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

93-7

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(79)90062-4

journal_volume

11

pub_type

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