[3H]zolpidem binding in alcohol-preferring and non-preferring rat brain.

Abstract:

:The present study has employed in vitro autoradiography to study the distribution and density of [3H]zolpidem binding sites, which are regarded as an index of ethanol-sensitive gamma-aminobutyric acid (GABA)A receptors, in the brains of alcohol-preferring Fawn-Hooded (FH) rats compared to non-alcohol preferring Wistar-Kyoto (WKY) rats. Binding of [3H]zolpidem showed a similar distribution profile in both rat strains examined and included cerebellum, globus pallidus, nucleus of the solitary tract and a number of midbrain/hindbrain nuclei. Densitometric quantitation of binding revealed that FH rats possessed a significantly higher density of [3H]zolpidem binding compared to WKY rats in cortical regions, substantia nigra pars reticulata and the ventral pallidum. These data indicate that FH rats may have an increased number of ethanol-sensitive GABA(A) receptors in regions intimately involved in reward processes, and may partially explain the alcohol-seeking nature of the FH rat.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Chen F,Rezvani A,Jarrott B,Lawrence AJ

doi

10.1016/s0304-3940(97)00867-7

subject

Has Abstract

pub_date

1997-12-05 00:00:00

pages

103-6

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(97)00867-7

journal_volume

238

pub_type

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