Abstract:
:The present study has employed in vitro autoradiography to study the distribution and density of [3H]zolpidem binding sites, which are regarded as an index of ethanol-sensitive gamma-aminobutyric acid (GABA)A receptors, in the brains of alcohol-preferring Fawn-Hooded (FH) rats compared to non-alcohol preferring Wistar-Kyoto (WKY) rats. Binding of [3H]zolpidem showed a similar distribution profile in both rat strains examined and included cerebellum, globus pallidus, nucleus of the solitary tract and a number of midbrain/hindbrain nuclei. Densitometric quantitation of binding revealed that FH rats possessed a significantly higher density of [3H]zolpidem binding compared to WKY rats in cortical regions, substantia nigra pars reticulata and the ventral pallidum. These data indicate that FH rats may have an increased number of ethanol-sensitive GABA(A) receptors in regions intimately involved in reward processes, and may partially explain the alcohol-seeking nature of the FH rat.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Chen F,Rezvani A,Jarrott B,Lawrence AJdoi
10.1016/s0304-3940(97)00867-7subject
Has Abstractpub_date
1997-12-05 00:00:00pages
103-6issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(97)00867-7journal_volume
238pub_type
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