Retinal dopamine sensitivity to MPP+ toxicity: electrophysiological and biochemical evaluation.

abstract：:We describe a novel aspect of action of memantine ex vivo, in the brain cortical slices and in vitro, in mixed glial cultures. The drug potently increased the production of kynurenic acid, an endogenous tryptophan metabolite blocking N-methyl-D-aspartate (NMDA) and nicotinic alpha7 receptors. In cortical slices memant...

journal_title：Neuroscience letters

authors： Kloc R,Luchowska E,Wielosz M,Owe-Larsson B,Urbanska EM

更新日期：2008-04-18 00:00:00

abstract：:To date only peptidergic innervation has been described in the alimentary tract of barnacles. In the present work the presence and distribution of choline acetyltransferase (ChAT), the acetylcholine (ACh) synthesizing enzyme, was investigated by immunohistochemistry in the alimentary tract of the adult barnacle Balanu...

journal_title：Neuroscience letters

authors： Gallus L,Ferrando S,Bottaro M,Girosi L,Ramoino P,Diaspro A,Aluigi MG,Tagliafierro G

更新日期：2006-12-06 00:00:00

abstract：:Near-infrared spectroscopy (NIRS) is a non-invasive optical technique which has been successfully used to register substantial cerebral ischemia. There are indications that NIRS is sensible enough to detect also small metabolic changes during the performance of cognitive tasks. In the present study, two-channel NIRS o...

journal_title：Neuroscience letters

authors： Fallgatter AJ,Strik WK

更新日期：1997-02-21 00:00:00

abstract：:The fine-tuning of topographically organized projections in sensory systems is strongly influenced by electrical activity and use-dependent modifications in synaptic strength. Since calcineurin (CaN), a Ca(2+)-calmodulin dependent serine/threonine phosphatase has been associated with activity-dependent modifications i...

journal_title：Neuroscience letters

authors： Trindade P,Antonioli-Santos R,Teixeira AC,Lanzillotta-Mattos B,Melibeu AC,Campello-Costa P,Linden R,Serfaty CA

更新日期：2011-01-03 00:00:00

abstract：:We studied anxiety-like behavior in the elevated plus-maze (EPM) tests in male Lewis rats on days 2 and 4 of adjuvant arthritis (AA). In plasma we analyzed C-reactive protein (CRP), albumin, ACTH, corticosterone, in the hippocampus the mRNA expression of interleukin-1β (IL-1β), interleukin-6 (IL-6), corticotrophin rel...

journal_title：Neuroscience letters

authors： Skurlova M,Stofkova A,Jurcovicova J

更新日期：2011-01-07 00:00:00

abstract：:The association between (GT)n dinucleotide repeats in monoamine oxidase gene loci, monoamine oxidase A (MAOA) and B (MAOB), and Parkinson's disease (PD), Alzheimer's disease (AD), and Lewy body variant (LBV) of AD were determined. MAOA-GT polymorphisms were significantly associated with pure AD and LBV. MAOA-GT allele...

journal_title：Neuroscience letters

authors： Takehashi M,Tanaka S,Masliah E,Ueda K

更新日期：2002-07-19 00:00:00

abstract：:The nasal cavity of vertebrates contains a variety of xenobiotic metabolizing enzymes that possess a broad range of substrate specificity ranging from metabolism of drugs, carcinogens, and steroid hormones, to dietary components and environmental pollutants. This investigation sought to localize the cellular expressio...

journal_title：Neuroscience letters

authors： Green N,Weech M,Walters E

更新日期：2005-03-03 00:00:00

abstract：:The heptadecapeptide histogranin, synthesized by adrenal chromaffin cells, is implicated in the analgesia produced by transplanting chromaffin cells into the spinal cord, including block of hyperalgesia mediated by NMDA-subtype glutamate receptors. To examine the neurophysiological basis for this analgesia, we applied...

journal_title：Neuroscience letters

authors： Hentall ID,Hargraves WA,Sagen J

更新日期：2007-05-23 00:00:00

abstract：:The aim of this study was to examine the ability of somatostatin receptor (sst(1)) to regulate the release of somatostatin in rat retina. Immunohistochemistry studies were performed to locate the somatostatin neurons, and radioligand binding to ascertain the presence of sst(1). The neuronal release of somatostatin was...

journal_title：Neuroscience letters

authors： Mastrodimou N,Thermos K

更新日期：2004-02-06 00:00:00

abstract：:This experiment was designed to simulate experimentally the specific parameters of geomagnetic activity that evoke epileptic seizures. The numbers of overt limbic seizures (rearing, paroxysmal forelimb clonus and falling) in a population of epileptic rats were recorded nightly for 65 successive days between 0200 and 0...

journal_title：Neuroscience letters

authors： Michon AL,Persinger MA

更新日期：1997-03-07 00:00:00

abstract：:We have recently shown that the cytoplasmic tail of the somatostatin receptor sst2 undergoes alternative splicing giving rise to two isoforms, SSt2A and sst2B. In the present study, we have raised polyclonal antibodies that specifically detect either sst2A or sst2B and used these antisera for immunocytochemical locali...

journal_title：Neuroscience letters

authors： Schulz S,Schmidt H,Händel M,Schreff M,Höllt V

更新日期：1998-11-20 00:00:00

abstract：:A compound action potential of short latency was recorded from the ganglion mesencephali extrolaterale in response to both the fish's own electric organ discharge and electric stimulation of the whole fish or a branch of the posterior lateral line nerve. The time difference between the response in the nerve, 16 mm fro...

journal_title：Neuroscience letters

authors： Enger PS,Libouban S,Szabo T

更新日期：1976-05-01 00:00:00

abstract：:Acetylcholinesterase (AChE) colocalizes with amyloid-beta peptide (A beta) deposits present in the brain of Alzheimer's patients. Recent studies showed that A beta 1-40 can adopt two different conformational states in solution (an amyloidogenic conformer, A beta ac, and a non-amyloidogenic conformer, A beta nac) which...

journal_title：Neuroscience letters

authors： Alvarez A,Bronfman F,Pérez CA,Vicente M,Garrido J,Inestrosa NC

更新日期：1995-12-01 00:00:00

abstract：:Recent evidence suggests a predominant role for potassium (K) efflux in apoptotic cell death yet there exists controversy as to the exact nature of this involvement of K. In the present study we tested the anti-apoptotic efficacy of K channel blockers, tetraethylammonium Cl (TEA), and high extracellular K, the sodium ...

journal_title：Neuroscience letters

authors： Small DL,Tauskela J,Xia Z

更新日期：2002-12-13 00:00:00

abstract：:Patients with schizophrenia are especially impaired in the detection of spatial location if the briefly presented target stimulus is followed by a mask in a close temporal proximity (target location backward masking (BM) paradigm). It has been suggested that this phenomenon is related to the impairment of low spatial ...

journal_title：Neuroscience letters

authors： Kéri S,Antal A,Szekeres G,Benedek G,Janka Z

更新日期：2000-10-20 00:00:00

abstract：:A cholesteryl ester transfer protein (CETP) genotype (V/V homozygosity for I405V, NCBI dbSNP rs5882) has been associated with preservation of cognitive function in old age, in addition to its associations with exceptional longevity and cardiovascular disease. We tested the hypotheses that this polymorphism was associa...

journal_title：Neuroscience letters

authors： Johnson W,Harris SE,Collins P,Starr JM,Whalley LJ,Deary IJ

更新日期：2007-06-13 00:00:00

abstract：:Prefoldin is a molecular chaperone that assists the folding of newly synthesized polypeptide chains and prevents aggregation of misfolded proteins. Dysfunction of prefoldin is one of the causes of neurodegenerative diseases such as Alzheimer's disease. The aim of this study was to clarify the involvement of prefoldin ...

journal_title：Neuroscience letters

authors： Kadoyama K,Matsuura K,Takano M,Maekura K,Inoue Y,Matsuyama S

更新日期：2019-11-01 00:00:00

abstract：:Purinoceptor agonists produced potassium currents with the order of potency: ATP > adenosine = ADP = AMP > beta,gamma-methylene ATP, while a small response or no response was induced by 2-methylthio ATP, UTP, or alpha,beta-methylene ATP. The response induced by beta,gamma-methylene ATP was completely inhibited in the ...

journal_title：Neuroscience letters

authors： Matsuoka T,Nishizaki T,Nomura T,Mori M,Okada Y

更新日期：1998-05-29 00:00:00

abstract：:Protein kinase G (PKG) has been implicated in a variety of physiological functions including synaptic plasticity in the brain. This study investigated the involvement of dopamine D3 (D3) receptors in PKG-regulated dopamine release, long-term changes in gene expression and behavioral sensitization after repeated cocain...

journal_title：Neuroscience letters

authors： Lee DK,Oh JH,Yang JH,Youn B,Shim YB,Shim I,Wang JQ,Choe ES

更新日期：2013-04-29 00:00:00

abstract：:Nanomolar concentrations of vasoactive intestinal peptide (VIP), picomolar concentrations of stearyl-norleucine17-VIP (SNV) and femtomolar concentrations of NAPVSIPQ (NAP), an 8-amino-acid peptide derived from the VIP-responsive activity-dependent neuroprotective protein, provide broad neuroprotection. In rat cerebral...

journal_title：Neuroscience letters

authors： Ashur-Fabian O,Giladi E,Furman S,Steingart RA,Wollman Y,Fridkin M,Brenneman DE,Gozes I

更新日期：2001-07-20 00:00:00

abstract：:RMI 12330A dose-dependently inhibits cAMP accumulation induced by PGE2 in guinea-pig superior cervical ganglion (SCG). Norepinephrine (NE) is unable to modify cAMP concentration in the same preparation. On the other hand, both PGE2 and NE block the firing discharge of guinea-pig SCG neurons elicited by electrical stim...

journal_title：Neuroscience letters

authors： Borasio PG,Ferretti ME,Biondi C,Trevisani A

更新日期：1982-10-08 00:00:00

abstract：:The dorsal margin of the trigeminal principal nucleus (PV) contains neurons responsive to innocuous thermal stimulation of the tongue and maybe a thermal relay (Hayama and Hashimoto, 2011). The present electrophysiological study examined whether PV thermoreceptive neurons project to the thalamus and investigated respo...

journal_title：Neuroscience letters

authors： Hayama T

更新日期：2014-04-03 00:00:00

abstract：:Three forms of stress-induced analgesia (electric shock, forced water-swim and novelty) were used to examine the nature of the endogenous antiopiate system. It was hypothesized that a role of the antiopiate system may be to regulate the extent of antinociception within varying environments. The antiopiate properties o...

journal_title：Neuroscience letters

authors： Galina ZH,Kastin AJ

更新日期：1988-02-03 00:00:00

abstract：:Intra-arterial (i.a.) injection of Indian red scorpion (Mesobuthus tamulus; BT) venom produces cardiorespiratory changes by involving perivascular receptors. The afferents involved in mediating these reflex responses are not known. The present investigation was conducted to examine the afferents mediating the vasosens...

journal_title：Neuroscience letters

authors： Singh SK,Deshpande SB

更新日期：2008-06-13 00:00:00

abstract：:An immobilisation stress (IS) of 2 h applied to rats at the beginning of the dark period (12 h), i.e. when the animals are more active, induces during the 10 consecutive h a significant rebound (+92%) of paradoxical sleep (PS) while slow-wave sleep state (SWS) is poorly affected. Two h of sleep deprivation, also appli...

journal_title：Neuroscience letters

authors： Rampin C,Cespuglio R,Chastrette N,Jouvet M

更新日期：1991-05-27 00:00:00

abstract：:The latency, duration of feeding and number of feeding periods recorded from rats after noradrenaline injection to the hippocampus show little change after unilateral 6-hydroxydopamine injections to the substantia nigra. It is suggested that 6-hydroxydopamine-induced weight losses result from non-specific effects of i...

journal_title：Neuroscience letters

authors： Oades RD

更新日期：1977-04-01 00:00:00

abstract：:We examined by immunohistochemistry the effect of salt loading on the expression of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and GTP cyclohydrolase I (GCH) in Purkinje cells of the mouse cerebellum. In control mice, only a few Purkinje cells were positive for TH or AADC. No Purkinje cells...

journal_title：Neuroscience letters

authors： Sakai M,Fujii T,Karasawa N,Arai R,Nagatsu I

更新日期：1995-07-14 00:00:00

abstract：:Event-related potentials were recorded from sleeping newborns to compare amplitudes and latencies of mismatch negativity (MMN) and late discriminative negativity (LDN) in active and quiet sleep stages. MMN and LDN were obtained in response to changes in semi-synthesized vowels from 20 healthy newborn infants. MMN and ...

journal_title：Neuroscience letters

authors： Martynova O,Kirjavainen J,Cheour M

更新日期：2003-04-10 00:00:00

abstract：BACKGROUND:A single session of aerobic exercise is linked to faster motor responses; however, the effect on rate of short-term learning is less clear. The objective was to evaluate the influence of a single bout of aerobic exercise on the rate of short-term acquisition of a shape-letter association task requiring a mot...

journal_title：Neuroscience letters

authors： Sage MD,Beyer KB,Laylor M,Liang C,Roy EA,McIlroy WE

更新日期：2016-08-26 00:00:00

abstract：:Retrograde axonal transport and fluorescent retrograde labelling of neurons were investigated in a crustacean motor system. A fluorescent tracer (Granular blue) was injected into an antennal muscle of rock lobster in order to identify the motor neurons innervating it. After an appropriate post-injection survival time,...

journal_title：Neuroscience letters

authors： Rossi-Durand C,Sorensen KE

更新日期：1985-04-09 00:00:00