Enhanced expression of tyrosine hydroxylase and aromatic L-amino acid decarboxylase in cerebellar Purkinje cells of mouse after hyperosmotic stimuli.

Abstract:

:We examined by immunohistochemistry the effect of salt loading on the expression of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and GTP cyclohydrolase I (GCH) in Purkinje cells of the mouse cerebellum. In control mice, only a few Purkinje cells were positive for TH or AADC. No Purkinje cells were stained for GCH. Drinking 2% sodium chloride for 2 weeks resulted in an increase in the number of TH- or AADC-positive Purkinje cells in the caudal vermis, paraflocculus and flocculus of the cerebellum. In contrast, no Purkinje cells were immunoreactive to GCH or L-DOPA after the salt loading. The present findings suggest that the salt loading differentially affects the expression of TH, AADC and GCH in Purkinje cells of the mouse cerebellum.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Sakai M,Fujii T,Karasawa N,Arai R,Nagatsu I

doi

10.1016/0304-3940(95)11716-a

subject

Has Abstract

pub_date

1995-07-14 00:00:00

pages

142-4

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

0304-3940(95)11716-A

journal_volume

194

pub_type

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