Abstract:
:We examined by immunohistochemistry the effect of salt loading on the expression of tyrosine hydroxylase (TH), aromatic L-amino acid decarboxylase (AADC), and GTP cyclohydrolase I (GCH) in Purkinje cells of the mouse cerebellum. In control mice, only a few Purkinje cells were positive for TH or AADC. No Purkinje cells were stained for GCH. Drinking 2% sodium chloride for 2 weeks resulted in an increase in the number of TH- or AADC-positive Purkinje cells in the caudal vermis, paraflocculus and flocculus of the cerebellum. In contrast, no Purkinje cells were immunoreactive to GCH or L-DOPA after the salt loading. The present findings suggest that the salt loading differentially affects the expression of TH, AADC and GCH in Purkinje cells of the mouse cerebellum.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Sakai M,Fujii T,Karasawa N,Arai R,Nagatsu Idoi
10.1016/0304-3940(95)11716-asubject
Has Abstractpub_date
1995-07-14 00:00:00pages
142-4issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(95)11716-Ajournal_volume
194pub_type
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