Marked increase in histamine H3 receptors in the striatum and substantia nigra after 6-hydroxydopamine-induced denervation of dopaminergic neurons: an autoradiographic study.

abstract：:The role of nitric oxide in cerebral insults remains controversial. While numerous studies have used models of ischaemia and hypoxia, few have examined nitric oxide in the kainate model of excitotoxicity. Kainate (10 mg/kg) was administered to rats via the intraperitoneal (i.p.) route to induce submaximal damage to th...

journal_title：Neuroscience letters

authors： Jones PA,Smith RA,Stone TW

更新日期：1998-06-19 00:00:00

abstract：:Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) may be effective in treating depression. Parental verbal abuse has been linked to decreased fractional anisotropy (FA) of white matter and reduced FA correlated with depression and anxiety scores. Utilizing a nonhuman primate model of moo...

journal_title：Neuroscience letters

authors： Coplan JD,Abdallah CG,Tang CY,Mathew SJ,Martinez J,Hof PR,Smith EL,Dwork AJ,Perera TD,Pantol G,Carpenter D,Rosenblum LA,Shungu DC,Gelernter J,Kaffman A,Jackowski A,Kaufman J,Gorman JM

更新日期：2010-08-16 00:00:00

abstract：:Nitric oxide synthase (NOS) immunoreactivity occurred in about 60% of ventromedial, ventrolateral, and sphincteric motoneurones in cat sacral spinal cord. Proportions of sacral motoneurones histochemically stained for NADPH-diaphorase, were similar, and equivalent in size to those immunoreactive for NOS, suggesting co...

journal_title：Neuroscience letters

authors： Pullen AH,Humphreys P

更新日期：1995-08-18 00:00:00

abstract：:Aripiprazole, a novel atypical antipsychotic drug, can significantly increase dopamine (DA) levels in the prefrontal cortex of rats, but only at low doses below 1mg/kg. The aim of the present work was to test the effect of aripiprazole (0, 0.1, 0.3, 3 and 30 mg/kg, i.p.) on extracellular levels of monoamines in the pr...

journal_title：Neuroscience letters

authors： Zocchi A,Fabbri D,Heidbreder CA

更新日期：2005-10-28 00:00:00

abstract：:The CHRNA7 gene encoding the α7 nicotinic acetylcholine receptor (nAChR) has repeatedly been linked with schizophrenia and the P50 sensory gating deficit. The α7 nAChR is considered a promising drug target for treatment of cognitive dysfunction in schizophrenia and improves memory and executive functions in patients a...

journal_title：Neuroscience letters

authors： Dyrvig M,Mikkelsen JD,Lichota J

更新日期：2019-06-21 00:00:00

abstract：:Localization of the epileptogenic zone (EZ) is an important issue in epileptology, even though there is not a unique definition of the epileptic focus. By using complex network analysis of electrocorticographic (ECoG) data we identify three singular areas in the temporal lobe of epileptic patients, the node with highe...

journal_title：Neuroscience letters

authors： Ortega GJ,Sola RG,Pastor J

更新日期：2008-12-12 00:00:00

abstract：:Cancer patients with bone metastases often suffer breakthrough pain. However, little progress has been made in the treatment of breakthrough pain and its associated mechanism(s) in the patient with cancer due to lacking of resembling and predictive animal models. We previously have demonstrated that endothelin-1 plays...

journal_title：Neuroscience letters

authors： Tang Y,Peng H,Liao Q,Gan L,Zhang R,Huang L,Ding Z,Yang H,Yan X,Gu Y,Zang X,Huang D,Cao S

更新日期：2016-03-23 00:00:00

abstract：:Stereotaxic microinjection of herpes simplex virus (HSV) into the mouse olfactory bulb resulted in infection of neurons of the piriform cortex. Neurons infected with the wildtype HSV showed no evident phosphorylation of c-Jun N-terminal protein kinase (JNK)/c-Jun. In contrast, neurons infected with a US3 gene-disrupte...

journal_title：Neuroscience letters

authors： Mori I,Goshima F,Koshizuka T,Koide N,Sugiyama T,Yoshida T,Yokochi T,Kimura Y,Nishiyama Y

更新日期：2003-11-20 00:00:00

abstract：:Employing video-enhanced contrast (VEC) microscopy, we examined whether TAK-029 (GPIIb/IIIa antagonist) inhibits the adhesion of activated platelets to human brain microvascular endothelial cells (HBEC) in vitro. HBECs were cultured on a coverglass and put in the observation chamber of VEC microscopy. Then, activated ...

journal_title：Neuroscience letters

authors： Tanahashi N,Fukuuchi Y,Tomita M,Tomita Y,Inoue K,Satoh H,Abe T

更新日期：2001-03-23 00:00:00

abstract：:For the first time, a review article focuses exclusively on the role of the protein kinase CK2 in mono- and poly-nucleated mammalian skeletal muscle cells. While CK2, a pleiotropic serine/threonine kinase was originally thought to phosphorylate mainly casein, later evidence found glycogen phosphorylase and glycogen sy...

journal_title：Neuroscience letters

authors： Hashemolhosseini S

更新日期：2020-06-11 00:00:00

abstract：:The presence and micro-anatomical localization of muscarinic cholinergic receptors were assessed in dorsal root ganglia of chick embryo during development using radioligand binding and immunocytochemical techniques, respectively. The non-selective muscarinic cholinergic receptor radioligand [3H]quinuclidinyl benzilate...

journal_title：Neuroscience letters

authors： Tata AM,Biagioni S,Ricci A,Amenta F,Augusti-Tocco G

更新日期：1995-04-21 00:00:00

abstract：:Turnover rates, as estimated from the accumulation of the intermediates, 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition, were used to investigate the relationship between central catecholaminergic and serotonergic neurons and the development of hypertension in the ...

journal_title：Neuroscience letters

authors： Shum AY,Chen CS,Hsu SC,Chen CF

更新日期：1987-03-31 00:00:00

abstract：:Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer drug. One obstacle in TRAIL-based therapies is that many cancer cells, including gliomas, are resistant towards TRAIL. In this study one glioblastoma cell line, one human short-term glioblastoma culture and human astrocytes were tre...

journal_title：Neuroscience letters

authors： Siegelin MD,Siegelin Y,Habel A,Gaiser T

更新日期：2009-04-03 00:00:00

abstract：:The purpose of this study was to determine if the effect of downslope walking (DSW) on spinal excitability depends on walking duration and slope steepness, and if findings from the soleus (Sol) generalize to the tibialis anterior (TA). Sol and TA Hmax and Mmax were measured before and after four DSW doses (time/slope,...

journal_title：Neuroscience letters

authors： Arnold E,Farmer B,Keightley M,Lee D,Rigel T,Hoque M,Sabatier MJ

更新日期：2017-02-03 00:00:00

abstract：:The simple cerebellar lobule is involved in several neuromotor processes and it is activated during guided exercise. Although guided exercises are essential for motor rehabilitation, the plastic events that occur in the simple cerebellar lobule during motor training remain unknown. In this study, normal adult rats wer...

journal_title：Neuroscience letters

authors： González-Burgos I,González-Tapia D,Zamora DA,Feria-Velasco A,Beas-Zárate C

更新日期：2011-03-24 00:00:00

abstract：:Since greater attention has been paid to the direct link of genetic variation to cognition and memory performance, apolipoprotein E (ApoE) and brain-derived neurotrophic factor (BDNF) have been the two most frequently studied genes. To investigate the effect of BDNF and ApoE polymorphisms on the cognitive profile of m...

journal_title：Neuroscience letters

authors： Nacmias B,Piccini C,Bagnoli S,Tedde A,Cellini E,Bracco L,Sorbi S

更新日期：2004-09-09 00:00:00

abstract：:In the last decade, several genes have been linked to Parkinson's disease (PD), including GIGYF2, ATP13A2 and GBA. To explore whether mutations in these genes contribute to development of PD in the Brazilian population, we screened 110 patients with early-onset PD. No clearly pathogenic mutations were identified in AT...

journal_title：Neuroscience letters

authors： Dos Santos AV,Pestana CP,Diniz KR,Campos M,Abdalla-Carvalho CB,de Rosso AL,Pereira JS,Nicaretta DH,de Carvalho WL,Dos Santos JM,Santos-Rebouças CB,Pimentel MM

更新日期：2010-11-19 00:00:00

abstract：:Imaging and lesion studies suggest that the cerebellum is involved in the self-generation of timed motor responses. Using repetitive transcranial magnetic stimulation (rTMS), we studied the effects of transient disruption of the lateral or medial cerebellum on a paced-finger-tapping task (PFT). Results show greater va...

journal_title：Neuroscience letters

authors： Théoret H,Haque J,Pascual-Leone A

更新日期：2001-06-22 00:00:00

abstract：:Interactions between subtypes of dopamine, glutamate and adenosine receptors seem to play an important integrative role in the function of striatal gamma-aminobutyric acid (GABA)ergic efferent neurons. Recent behavioral and biochemical studies suggest the existence of specific interactions between adenosine A2A recept...

journal_title：Neuroscience letters

authors： Díaz-Cabiale Z,Vivó M,Del Arco A,O'Connor WT,Harte MK,Müller CE,Martínez E,Popoli P,Fuxe K,Ferré S

更新日期：2002-05-17 00:00:00

abstract：:The present study was designed to determine whether a state of neuropathic pain induced by sciatic nerve ligation could alter phosphorylated-mu-opioid receptor-like immunoreactivity in the superficial dorsal horn of the mouse spinal cord. Mice with sciatic nerve ligation exhibited a significant suppression of the morp...

journal_title：Neuroscience letters

authors： Narita M,Kuzumaki N,Suzuki M,Narita M,Oe K,Yamazaki M,Yajima Y,Suzuki T

更新日期：2004-01-09 00:00:00

abstract：:Neuropathic pain (NP) is one of the most common complications after spinal cord injury (SCI), but no protein biomarkers has ever been introduced into clinical diagnosis. Previous studies implicated that toll-like receptor (TLR) 4 played a critical role in the development of NP in animal SCI models. Here, a total of 14...

journal_title：Neuroscience letters

authors： Xu J,E X,Liu H,Li F,Cao Y,Tian J,Yan J

更新日期：2015-05-19 00:00:00

abstract：:Neurotrophic factors may be used to improve the growth and repair of injured peripheral nerves. In this study we determined the effectiveness of recombinant human growth hormone on peripheral nerve injury in the Wistar rat. The ulnar nerve of the rat was sectioned and its proximal and distal ends were sutured to eithe...

journal_title：Neuroscience letters

authors： Saceda J,Isla A,Santiago S,Morales C,Odene C,Hernández B,Deniz K

更新日期：2011-10-24 00:00:00

abstract：:The blood-brain barrier (BBB) plays an important role in controlling the passage of molecules from the blood to the extracellular fluid environment of the brain. An immortalised rat brain endothelial cell line (GPNT) was used to investigate the mechanisms underlying dexamethasone-induced decrease in paracellular perme...

journal_title：Neuroscience letters

authors： Romero IA,Radewicz K,Jubin E,Michel CC,Greenwood J,Couraud PO,Adamson P

更新日期：2003-06-26 00:00:00

abstract：:Changes in the activity of gamma-glutamyl transpeptidase (GGTP) and the effects of a subacute dose (150 mg/kg b.wt.) of methionine sulfoximine (MSO) on its activity were studied in cerebral cortex, cerebellum and brainstem of rats of 4 different age groups. GGTP activity increased with increasing age between days 10 a...

journal_title：Neuroscience letters

authors： Rao VL,Murthy CR

更新日期：1991-05-13 00:00:00

abstract：:The effects of Sr2+ on the transmitter release at the frog neuromuscular junction were examined electrophysiologically. The nerve trunk was stimulated by paired pulses at various time intervals after replacing extracellular Ca2+ by Sr2+, the paired-pulse facilitation at the 10 ms interval was smaller than that at 20-3...

journal_title：Neuroscience letters

authors： Tanabe N,Morota A

更新日期：1999-11-19 00:00:00

abstract：:In anesthetized rats, injections of a 0.5 mM glutamate solution into the locus coeruleus (LC) reversibly increased the amplitude of the population spike evoked in CA1 by stimulation of the Schaffer-commissural fiber tract. This effect was absent in N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4)-treated, noradren...

journal_title：Neuroscience letters

authors： Olpe HR,Laszlo J,Pozza MF,De Herdt P,Waldmeier PC,Jones RS

更新日期：1986-03-28 00:00:00

abstract：:The intergeniculate leaflet (IGL) of the lateral geniculate complex is marked by the presence of neuro-peptide Y-containing neurons that project to the suprachiasmatic nuclei (SCN) of the hypothalamus. In the present study, we demonstrate that both the IGL and SCN in the hamster and rat are specifically delineated by ...

journal_title：Neuroscience letters

authors： Morin LP,Johnson RF,Moore RY

更新日期：1989-04-24 00:00:00

abstract：:A free radical scavenger edaravone is clinically used in Japan for acute stroke, and several basic researches have carefully examined the mechanisms of edaravone's protective effects. However, its actions on pro-inflammatory responses under stroke are still understudied. In this study, we subjected adult male Sprague-...

journal_title：Neuroscience letters

authors： Fujiwara N,Som AT,Pham LD,Lee BJ,Mandeville ET,Lo EH,Arai K

更新日期：2016-10-28 00:00:00

abstract：:Previous studies using 2-deoxyglucose (2-DG) autoradiography have demonstrated that the suprachiasmatic nucleus (SCN) of the hypothalamus, a putative neural circadian pacemaker, displays circadian rhythmicity in its metabolic activity. In the present study, we show that distinct circadian variations in 2-DG uptake occ...

journal_title：Neuroscience letters

authors： Rosenwasser AM,Trubowitsch G,Adler NT

更新日期：1985-07-31 00:00:00

abstract：:In order to study the rapidity of interaction between tetraethylammonium (TEA) and the delayed K+ channel of the mammalian brain neuron, TEA was applied to isolated rat hippocampal pyramidal neurons in a time-controlled sequence with a voltage step using a concentration clamp technique. TEA at a concentration of 30 mM...

journal_title：Neuroscience letters

authors： Oyama Y,Harata N,Akaike N

更新日期：1991-10-14 00:00:00