Study of breakthrough cancer pain in an animal model induced by endothelin-1.

abstract：:Several studies have suggested that the activity of nitric oxide synthase (NOS) may be involved in the regulation of food intake in the genetically obese Zucker rats. In the present study, we investigated the expression of NOS in various hypothalamic regions of obese and lean Zucker rats using nicotinamide adenine din...

journal_title：Neuroscience letters

authors： Kim MJ,Kim Y,Choe BK,Kim SA,Lee HJ,Kim JW,Huh Y,Kim C,Chung JH

更新日期：2000-09-29 00:00:00

abstract：:Maternal infection during pregnancy increases the risk of neurodevelopmental conditions such as autism spectrum disorders and schizophrenia in offspring. Several previous animal studies have indicated that maternal immune activation (MIA), rather than a specific pathogen, alters fetal brain development. Among them, pr...

journal_title：Neuroscience letters

authors： Zuiki M,Chiyonobu T,Yoshida M,Maeda H,Yamashita S,Kidowaki S,Hasegawa T,Gotoh H,Nomura T,Ono K,Hosoi H,Morimoto M

更新日期：2017-07-13 00:00:00

abstract：:The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings ...

journal_title：Neuroscience letters

authors： Sörös P,Knecht S,Bantel C,Imai T,Wüsten R,Pantev C,Lütkenhöner B,Bürkle H,Henningsen H

更新日期：2001-02-09 00:00:00

abstract：:Long-term potentiation (LTP) of perforant-path dentate granule cell synapses, in awake rats, was followed by a time-dependent expression of brain-derived neurotrophic factor (BDNF) mRNA in dentate granule cells. This BDNF expression was blocked by the N-methyl-D-aspartate (NMDA) antagonist dizocilpine maleate (MK-801)...

journal_title：Neuroscience letters

authors： Dragunow M,Beilharz E,Mason B,Lawlor P,Abraham W,Gluckman P

更新日期：1993-10-01 00:00:00

abstract：:Doxorubicin, a fluorescent retrograde neurotoxin, killed neurons in the ventral tegmentum and thalamus that were afferent to the injection site in the caudate-putamen. The neurotoxic effects in the ventral tegmentum and thalamus were prevented by a large coronal knife cut caudal to the injection site in the striatum, ...

journal_title：Neuroscience letters

authors： van der Kooy D,Zito KA,Roberts DC

更新日期：1985-01-21 00:00:00

abstract：:Activities of motor units of human tibialis anterior muscle were studied when the subject maintained the force of the muscle at a constant level voluntarily. Motor units were classified into two main groups according to their discharge frequencies and their tensions. Those units which were recruited from the beginning...

journal_title：Neuroscience letters

authors： Kato M,Murakami S,Takahashi K,Hirayama H

更新日期：1981-09-01 00:00:00

abstract：:We present results of homozygosity mapping in two siblings affected with early onset Parkinson's disease (EOPD) and mutation screening of ATP13A2 in these and other Iranian EOPD patients. Genome-wide SNP homozygosity analysis revealed linkage to a locus that included ATP13A2, and sequencing of the gene revealed a nove...

journal_title：Neuroscience letters

authors： Malakouti-Nejad M,Shahidi GA,Rohani M,Shojaee SM,Hashemi M,Klotzle B,Fan JB,Elahi E

更新日期：2014-08-08 00:00:00

abstract：:Many gene expression studies have examined postmortem brain tissues of patients with schizophrenia. However, only a few expression studies of the genes identified in genome-wide association study (GWAS) have been published to date. We measured the expression levels of the genes identified in GWAS (ZNF804A, OPCML, RPGR...

journal_title：Neuroscience letters

authors： Umeda-Yano S,Hashimoto R,Yamamori H,Weickert CS,Yasuda Y,Ohi K,Fujimoto M,Ito A,Takeda M

更新日期：2014-05-07 00:00:00

abstract：:Agmatine (decarboxylated arginine) has been proposed as an endogenous ligand for non-adrenoceptor, imidazoline binding sites, but also binds to alpha 2-adrenoceptors. The interaction of agmatine with alpha 2-adrenoceptors was evaluated by studying the effect of agmatine on the firing rate of locus coeruleus (LC) neuro...

journal_title：Neuroscience letters

authors： Pineda J,Ruiz-Ortega JA,Martín-Ruiz R,Ugedo L

更新日期：1996-11-22 00:00:00

abstract：:In elucidating the possible involvement of histamine (His) in hyperalgesia to heat, the effects of His on the heat response of testicular polymodal receptors were studied in vitro in canine testis-spermatic nerve preparations. His (100 and 1000 microM) induced discharges > 0.5 impulses/s (high-responders) in about one...

journal_title：Neuroscience letters

authors： Mizumura K,Minagawa M,Koda H,Kumazawa T

更新日期：1994-02-28 00:00:00

abstract：:The magnocellular neurones of the supraoptic nucleus (SON) and paraventricular nucleus release neuropeptide from their axon terminals and also from their dendrites. In the axon terminals, swellings known as Herring bodies are responsible for the degradation of aged, unreleased large dense-cored vesicles (LDCVs) by lys...

journal_title：Neuroscience letters

authors： Monteiro O,Wiegand UK,Ludwig M

更新日期：2011-02-01 00:00:00

abstract：:The possible involvement of 2-amino-4-phosphonobutyrate (APB) recognition sites in mechanisms enabling the maintenance of long-term potentiation (LTP) was investigated in rat hippocampal slices. The action of D(-)- and L(+)-isomers of APB was tested on orthodromic EPSP and spike responses recorded extracellularly from...

journal_title：Neuroscience letters

authors： Reymann KG,Matthies H

更新日期：1989-03-27 00:00:00

abstract：:The effect of diffuse luminance flicker stimulation of a large area (approximately 30 degrees diameter) on red blood cell flux (F) in the optic nerve head was measured in the anesthetized cat. F increased markedly during sustained flicker. The F-response to the initiation and cessation of the stimulation was found to ...

journal_title：Neuroscience letters

authors： Riva CE,Harino S,Shonat RD,Petrig BL

更新日期：1991-07-22 00:00:00

abstract：:Morphine and other opioids have direct analgesic actions in the spinal cord and chronic spinal administration of opioid agonists is used clinically in patients suffering from severe, chronic pain. Neuropathic pain resulting from peripheral nerve injury is often less sensitive to opioid therapy than other forms of chro...

journal_title：Neuroscience letters

authors： Stone LS,Vulchanova L,Riedl MS,Williams FG,Wilcox GL,Elde R

更新日期：2004-05-06 00:00:00

abstract：:The nicotinic acetylcholine receptor (nAChR) antagonist alpha-bungarotoxin (alpha-Btx) binds to two different classes of high affinity binding sites from the Drosophila central nervous system. We have used the bivalent reagent 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDAC) to cross-link 125I-alpha-Btx (M(r) = ...

journal_title：Neuroscience letters

authors： Schloss P,Mayser W,Gundelfinger ED,Betz H

更新日期：1992-09-28 00:00:00

abstract：:Membrane microdomains (MDs), or lipid rafts, are recently identified dynamic membrane domains on which various signal-transductions are performed. Intracellular Ca(2+)-binding proteins participate in the Ca(2+) signaling through interaction with various proteins. Neurocalcin alpha (NCalpha) is a member of neuronal cal...

journal_title：Neuroscience letters

authors： Masutani T,Taguchi K,Kumanogoh H,Nakamura S,Maekawa S

更新日期：2008-06-13 00:00:00

abstract：:The time-variant quadratic phase coupling (QPC) in trace alternant (TA) EEG patterns in healthy full-term neonates (quiet sleep) was investigated by means of time-variant bispectral analysis. The frequency plain 1-1.5 Hz <=> 3.5-4.5 Hz was used as the region-of-interest. QPC rhythms with a frequency of approximately 0...

journal_title：Neuroscience letters

authors： Schwab K,Putsche P,Eiselt M,Helbig M,Witte H

更新日期：2004-10-21 00:00:00

abstract：:The actions of huperzine A (HupA), a novel cholinesterase inhibitor, on the sustained potassium current were investigated in acutely dissociated hippocampal neurons of rat. HupA inhibited the current (IC(50) = 856 +/- 1 microM) with voltage-dependency. The effect was insensitive to 3 microM atropine. Tacrine (IC(50) =...

journal_title：Neuroscience letters

authors： Li Y,Hu GY

更新日期：2002-08-30 00:00:00

abstract：:The effect of sex, postmortem delay and aging on alpha 2-adrenoceptor binding was studied in tissue sections from several representative regions of the human brain from 21 subjects using [3H]UK-14304 as a ligand. Sex and postmortem delay did not influence the density of alpha 2-receptors. Aging resulted in clear decre...

journal_title：Neuroscience letters

authors： Pascual J,del Arco C,González AM,Díaz A,del Olmo E,Pazos A

更新日期：1991-12-09 00:00:00

abstract：:To examine the effect of apolipoprotein E (ApoE) 4 on the progression of Alzheimer's disease (AD), the clinical course of 33 AD patients (17 cases with ApoE epsilon4 and 16 cases without ApoE epsilon4) was evaluated with the mini-mental state examination (MMSE) and cerebrospinal fluid (CSF) biological markers. The dec...

journal_title：Neuroscience letters

authors： Kanai M,Shizuka M,Urakami K,Matsubara E,Harigaya Y,Okamoto K,Shoji M

更新日期：1999-05-21 00:00:00

abstract：:Lesion-induced degeneration was combined with immunocytochemistry to study, with electron microscopy, the synaptic connectivity between corticothalamic axon terminals from the first and second somatosensory areas and local circuit neurons of the ipsilateral ventrobasal complex (VB), selectively labelled with an antibo...

journal_title：Neuroscience letters

authors： Barbaresi P,Manzoni T

更新日期：2003-03-27 00:00:00

abstract：:The effect of electrical stimulation of the dorsal hippocampus on accumbens dopamine release was examined. Stimulation of the kindled hippocampus that produced stage 3 seizures evoked a brief increase in extracellular DA and DOPAC levels in the contralateral nucleus accumbens. In contrast, similar stimulation early in...

journal_title：Neuroscience letters

authors： Strecker RE,Moneta ME

更新日期：1994-08-01 00:00:00

abstract：:The effect of the N-methyl-D-aspartate (NMDA) receptor antagonist, 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), on the ethanol-evoked release of brain ascorbate (AA) was investigated in freely moving rats using an in vivo voltammetry technique. Ethanol (1.0 g/kg, intraperitoneal injection, i.p.) increase...

journal_title：Neuroscience letters

authors： Wu C

更新日期：1993-07-09 00:00:00

abstract：:Rhythms of plasma melatonin levels were determined in lizards (Tiliqua rugosa) subjected to a 12 h photocycle (12 h light: 12 h dark) at constant 33 degrees C, and at 7 different thermoperiods (33 degrees C thermophase and 15 degrees C cryophase) whose thermophase duration ranged from 1.5 to 21 h. The melatonin secret...

journal_title：Neuroscience letters

authors： Firth BT,Kennaway DJ,Belan I

更新日期：1991-01-02 00:00:00

abstract：OBJECTIVE:Exploring the impact of glucocerebrosidase gene (GBA) polymorphisms and mutations on the pathogenesis of Parkinson's disease dementia (PDD) plays an important role in the diagnosis and treatment of this disease. This meta-analysis aimed to investigate the effects of GBA polymorphisms and mutations on the risk...

journal_title：Neuroscience letters

authors： Zhang Y,Chen J,Xu C,Feng J,Li J

更新日期：2020-01-01 00:00:00

abstract：:The neurotransmitter gamma-aminobuteric acid (GABA) is believed to have a controlling action on spinal locomotor networks. In spasticity, spinal locomotor networks are thought to play a role. A well known drug in the treatment of spasticity is the GABA(B) agonist Baclofen. We report an inhibitory effect of Baclofen on...

journal_title：Neuroscience letters

authors： de Louw AJ,de Vente J,Steinbusch HP,Steinbusch HW,Troost J,Vles JS

更新日期：2002-03-15 00:00:00

abstract：:Perception of limb position and motion is abnormal in Parkinson's disease (PD). Despite the fact that the processing of proprioceptive inputs is inherently temporal, most studies have assessed spatial aspects of proprioception in PD patients. Here, we use a recently described method to test whether deficits also exist...

journal_title：Neuroscience letters

authors： Fiorio M,Stanzani C,Rothwell JC,Bhatia KP,Moretto G,Fiaschi A,Tinazzi M

更新日期：2007-05-07 00:00:00

abstract：:Immunolocalization of 14-3-3 protein isoforms in relation to Pick bodies in Pick body disease (PBD) brains was investigated. Weakly granular immunoreactivity of 14-3-3 proteins was found in neurons in control subjects and in Pick body disease brains. In addition to this granular immunoreactivity, many Pick bodies were...

journal_title：Neuroscience letters

authors： Umahara T,Uchihara T,Tsuchiya K,Nakamura A,Ikeda K,Iwamoto T,Takasaki M

更新日期：2004-11-23 00:00:00

abstract：:Rehabilitation is a process which favors recovery after brain damage involving motor systems, and neural plasticity is the only real resource the brain has for inducing neurobiological events in order to bring about re-adaptation. Rats were placed on a treadmill and made to walk, in different groups, at different velo...

journal_title：Neuroscience letters

authors： Vázquez-Hernández N,González-Tapia DC,Martínez-Torres NI,González-Tapia D,González-Burgos I

更新日期：2017-09-14 00:00:00

abstract：:This study aimed to investigate the cross-modal association of an "abstract symbol," designed for representation of an odor, with its corresponding odor. First, to explore the associations of abstract symbols with odors, participants were asked to match 8 odors with 19 different abstract symbols (Experiment 1). Next, ...

journal_title：Neuroscience letters

authors： Seo HS,Arshamian A,Schemmer K,Scheer I,Sander T,Ritter G,Hummel T

更新日期：2010-07-12 00:00:00