Abstract：
:Doxorubicin, a fluorescent retrograde neurotoxin, killed neurons in the ventral tegmentum and thalamus that were afferent to the injection site in the caudate-putamen. The neurotoxic effects in the ventral tegmentum and thalamus were prevented by a large coronal knife cut caudal to the injection site in the striatum, suggesting that retrograde transport of doxorubicin is necessary for the death of afferent neurons. In the striatum the neurotoxic effects of doxorubicin 14 days post-injection were quantitatively much greater on afferent neurons (as assessed by a 72% drop in dopamine levels) than on local striatal perikarya (as evidenced by the small 22% drop in the activity of glutamic acid decarboxylase). Doxorubicin may be a useful tool for selectively destroying, by way of retrograde transport, neurons that are afferent to a site in the brain.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
van der Kooy D,Zito KA,Roberts DCdoi
10.1016/0304-3940(85)90188-0subject
Has Abstractpub_date
1985-01-21 00:00:00pages
215-9issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(85)90188-0journal_volume
53pub_type
杂志文章abstract：:The blood-brain barrier (BBB) maintains the homeostasis between the central nervous system and the blood circulation. One of the main efflux transporter proteins at the BBB is P-glycoprotein (P-gP) also known as ABCB1 or MDR1. Due to the important role of P-gP for the transport barrier function of the BBB, the presenc...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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doi：10.1016/0304-3940(80)90249-9
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abstract：:Methylphenidate (MPH) is a dopamine and norepinephrine reuptake inhibitor that is widely used for the treatment of attention-deficit/hyperactivity disorder in children and adults. Its similarity to other psychostimulants suggests that, at certain doses, the drug may generate lasting neuroadaptations that can be detrim...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1986-07-11 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.10.064
更新日期：2005-02-25 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12387-9
更新日期：1996-02-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：1989-11-20 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(77)90043-x
更新日期：1977-07-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.04.053
更新日期：2007-06-04 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90771-z
更新日期：1990-10-30 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.03.002
更新日期：2004-04-29 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00717-4
更新日期：1998-10-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90276-5
更新日期：1988-11-22 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2011.08.001
更新日期：2011-09-26 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90053-9
更新日期：1985-06-12 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章,评审
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更新日期：2013-12-17 00:00:00
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journal_title：Neuroscience letters
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更新日期：1991-12-09 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.06.047
更新日期：2004-09-09 00:00:00
abstract：:Epigallocatechin-3-gallate (EGCG) is a powerful antioxidant with suggested neuroprotective action. This study investigated the protective effects of EGCG against retinal ganglion cells (RGCs) degeneration in an animal model of glaucoma. C57BL/6J mice (n=54) were divided randomly into four groups: normal control group ...
journal_title：Neuroscience letters
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更新日期：2015-07-23 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2010.01.061
更新日期：2010-03-19 00:00:00
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journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2005.08.044
更新日期：2006-01-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.11.061
更新日期：2009-02-06 00:00:00
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journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2019.03.030
更新日期：2019-06-11 00:00:00
abstract：:In order to study the influence of curare and atropine on the gamma-aminobutyric acid (GABA)-evoked chloride current, we have investigated cultures of hippocampal and septal region neurons from embryonic rats (E18). The neurons were cultured under the trophic influence of spatially separated astrocytes in serum-free m...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90085-7
更新日期：1988-11-11 00:00:00
abstract：:Spirulina maxima is a blue-green micro alga that contains abundant amounts of proteins (60-70%), vitamins, chlorophyll a, and C-phycocyanin (C-PC). It has been shown to reduce oxidative stress, and prevent diabetes and non-alcoholic fatty liver disease. However, it is unclear whether Spirulina maxima 70% ethanol extra...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.02.057
更新日期：2018-04-23 00:00:00
