Mecamylamine is a selective non-competitive antagonist of N-methyl-D-aspartate- and aspartate-induced currents in horizontal cells dissociated from the catfish retina.

abstract：:In this report, we describe an efficient and non-enzymatic method for isolating and culturing endothelial cells (ECs) from the nidus of surgically resected arteriovenous malformation (AVM) specimens. These cultured cells possessed typical phenotypic markers (i.e. von Willebrand factor and CD34), as well as morphologic...

journal_title：Neuroscience letters

authors： Zhang HF,Liang GB,Zhao MG,Song ZQ,Xu ZH

更新日期：2013-08-26 00:00:00

abstract：:Bound and free acetylcholine (ACh) were measured in frog sartorius muscles by mass fragmentography. Upon incubation of the muscles for 5 min with potassium propionate, which stimulated the release of ACh, there was a 2-fold reduction of bound ACh. In contrast, the amount of free ACh remained unchanged. After 65 min re...

journal_title：Neuroscience letters

authors： Molenaar PC,Polak RL

更新日期：1983-12-30 00:00:00

abstract：:Controversy exists regarding the site where anesthetics act in the brain to produce sedation and unconsciousness. Actions in the cerebral cortex and thalamus are likely, although the relative importance of each site is unclear. We used in computo modeling to investigate the sensitivity of cortical and thalamic neurons...

journal_title：Neuroscience letters

authors： Judge O,Hill S,Antognini JF

更新日期：2009-10-23 00:00:00

abstract：:P2Y(1) is probably an important subtype of purinergic receptors (P2Rs) in modulation of the astrocyte activation in spinal cord. The aim of this study was to observe the effect of P2Y(1) receptor on the abnormal energy metabolism of the cultured rat spinal astrocyte induced by extracellular adenosine diphosphate (ADP)...

journal_title：Neuroscience letters

authors： Cui J,Ou S,He WJ,Du L,Zhao YD,Ruan HZ

更新日期：2011-10-10 00:00:00

abstract：:It is believed that subjects with high trait anxiety levels tend to present state anxiety reactions with greater intensity than individuals with low trait anxiety levels. In order to verify if this premise is valid for animal models of anxiety, the present work investigated the possible correlation between two behavio...

journal_title：Neuroscience letters

authors： Goes TC,Antunes FD,Teixeira-Silva F

更新日期：2009-02-06 00:00:00

abstract：:New psychoactive substances (NPSs), i.e., newly designed substances with chemical residues that are slightly different from those of known psychoactive substances, have been emerging since the late 2000s, and social problems related to the use of these substances are increasing globally. Two such NPSs are 4-chloro-2,5...

journal_title：Neuroscience letters

authors： Cha HJ,Jeon SY,Jang HJ,Shin J,Kim YH,Suh SK

更新日期：2018-05-29 00:00:00

abstract：:The effects of intrathecal injections of morphine and other opioid receptor selective drugs were tested on urinary bladder contractions in the anesthetized rat. Morphine produced dose-related inhibition of bladder motility which was abolished by naloxone. This action was also observed with mu- and delta-opioid recepto...

journal_title：Neuroscience letters

authors： Dray A,Metsch R

更新日期：1984-06-01 00:00:00

abstract：:This investigation was designed to determine the responses of neurons in the posterior group of nuclei (PO) to tooth pulp stimulation. Eighteen tooth pulp-driven (TPD) neurons were recorded in 9 cats anesthetized with nitrous oxide and halothane, 14 of them in the medial part (POM) and the remainder in the lateral par...

journal_title：Neuroscience letters

authors： Matsumoto N,Sato T,Sawano H,Tochinai A,Suzuki TA

更新日期：1988-11-11 00:00:00

abstract：:We have previously shown that D-cycloserine displaces [3H]glycine binding to a recognition site with properties consistent with an N-methyl-D-aspartate (NMDA) receptor modulatory site. Additionally, D-cycloserine positively modulates the NMDA receptor as evidenced by its dose-dependent enhancement of [3H]1-[1-(2-thien...

journal_title：Neuroscience letters

authors： Hood WF,Compton RP,Monahan JB

更新日期：1989-03-13 00:00:00

abstract：:The pathogenic mechanism underlying Parkinson's disease (PD) and PD- Cognitive impairment (CI) remains elusive. Its potential link to the risk factors in Alzheimer's disease (AD) is unclear. In this study, we analyzed 16 CE-associated single nucleotide polymorphisms (SNPs) in twelve genes in a Chinese cohort of 450 PD...

journal_title：Neuroscience letters

authors： Fang L,Tang BS,Fan K,Wan CM,Yan XX,Guo JF

更新日期：2018-06-11 00:00:00

abstract：BACKGROUND:Brain function relies on the capacity of neurons to locally modulate each other at the level of synapses. Therefore, the exosomal pathway may constitute a well-designed mechanism for local and systemic interneuronal transfer of information within functional brain networks. Exosomes bind to and are endocytose...

journal_title：Neuroscience letters

authors： Yu X,Abdul M,Fan BQ,Zhang L,Lin X,Wu Y,Fu H,Lin Q,Meng H

更新日期：2020-04-01 00:00:00

abstract：:Systemic administration of nitroglycerin (NTG) consistently provokes spontaneous-like migraine attacks in migraine sufferers, and in rat it induces hyperalgesia and allodynia. In the present study we modeled migraine headache by intraperitoneal (i.p.) injection of a single dose of NTG, which produced widespread therma...

journal_title：Neuroscience letters

authors： Farajdokht F,Babri S,Karimi P,Mohaddes G

更新日期：2016-09-06 00:00:00

abstract：:The 22Na+ efflux stimulated by selected agonists of the 4 excitatory amino acid receptors, previously detected in the striatum, has been studied on 22Na+-preloaded slices prepared from 10 major areas of the rat brain. All brain areas were found to be sensitive, albeit to varying extents, to excitatory amino acids. The...

journal_title：Neuroscience letters

authors： Luini A,Goldberg O,Teichberg VI

更新日期：1983-11-11 00:00:00

abstract：:Alzheimer's disease has become one of the most impacting disorders since world population is rapidly aging. MicroRNA-125b plays a crucial role in many cellular processes and pathologies, but, to date, its role in Alzheimer's disease is controversial. In this study, we demonstrated, for the first time, that the down re...

journal_title：Neuroscience letters

authors： Micheli F,Palermo R,Talora C,Ferretti E,Vacca A,Napolitano M

更新日期：2016-08-26 00:00:00

abstract：:Previously, we have demonstrated that pressure-ejected application of angiotensin II and losartan, an angiotensin AT1 receptor antagonist, onto some neurons in the anterior hypothalamic area (AHA) of the rat increases and decreases, respectively, the basal firing rate of the neurons. To investigate possible participat...

journal_title：Neuroscience letters

authors： Hagiwara Y,Kubo T

更新日期：2007-04-12 00:00:00

abstract：:Existing literature concerning the effect of experimentally-induced diabetes on pain thresholds in rodent models remains controversial. In this work, we describe a phenotypical switch from streptozotocin-induced pinprick hypoalgesia to hyperalgesia observed in the same laboratory, in the same strain of rats, obtained ...

journal_title：Neuroscience letters

authors： Yadlapalli JSK,Dogra N,Walbaum AW,Prather PL,Crooks PA,Dobretsov M

更新日期：2018-04-23 00:00:00

abstract：:Hippocampal volumetry has been proposed to aid in the early diagnosis of Alzheimer's disease (AD) and to monitor progression of the disease. While this is believed to be as a result of hippocampal neuron loss, this association has not been firmly established and loss of other tissue elements may be responsible for the...

journal_title：Neuroscience letters

authors： Kril JJ,Hodges J,Halliday G

更新日期：2004-05-06 00:00:00

abstract：:Both substance P (SP)- and epinephrine-containing neurons in the rostral ventrolateral medulla have been thought to play a role in regulating vasomotor tone. The combination of retrograde transport of a fluorescent dye (Fast Blue) and immunofluorescent staining for SP- and phenylethanolamine-N-methyltransferase (PNMT)...

journal_title：Neuroscience letters

authors： Lorenz RG,Saper CB,Wong DL,Ciaranello RD,Loewy AD

更新日期：1985-04-19 00:00:00

abstract：:Nitric oxide synthase-immunoreactivity (NOS-IR) was detected in strands of nerve fibers entering the rat superior cervical ganglia (SCG) and in nerve fibers forming a plexus beneath the capsule of adrenal glands. Within the SCG, varicose NOS-IR fibers encircled virtually all postganglionic neurons and small diameter c...

journal_title：Neuroscience letters

authors： Dun NJ,Dun SL,Wu SY,Förstermann U

更新日期：1993-08-06 00:00:00

abstract：:Pain threshold and pain tolerance of heat noxious stimuli were assessed to determine whether they are equivalent when measured at three equidistant sites of both volar forearms. Heat pain threshold and tolerance were measured in 18 healthy volunteers using a standard stimulation device consisting of a thermode. Pain t...

journal_title：Neuroscience letters

authors： Schaffner N,Wittwer A,Kut E,Folkers G,Benninger DH,Candia V

更新日期：2008-08-08 00:00:00

abstract：:A modified "cross-modal delayed response" paradigm was used to investigate putative processing of face expression in the absence of focused attention to the face. Neutral, happy and sad faces were presented during intervals occurring between a tone and a response imperative signal (a faint click), while subjects were ...

journal_title：Neuroscience letters

authors： Zhao L,Li J

更新日期：2006-12-20 00:00:00

abstract：:Dual innervation, two morphologically distinct axons ending on the same endplate of white muscle, has been observed in some 'primitive' fish but not 'higher' teleosts. A representative of the order Bachtrachoidiformes, Opsanus tao, was examined using histological sectioning and silver impregnation to determine the inn...

journal_title：Neuroscience letters

authors： Raso DS

更新日期：1990-08-24 00:00:00

abstract：:The perinatal period of brain is characterized by dynamic changes in structure and high propensity for epilepsy. Animal models have shown that alterations of AMPA receptor (AMPAR) assembly or function may be related to seizure-induced cell damage, long-lasting impairments in brain development and seizure threshold. Ho...

journal_title：Neuroscience letters

authors： Jiang Q,Wang J,Wu Y,Wu X,Qin J,Jiang Y

更新日期：2008-10-17 00:00:00

abstract：:We investigated a possible involvement of the prion protein in ventilatory control in four groups of mice, those deficient for the prion protein (PrP(c)), those overexpressing the prion protein, and two groups of genetically and age-matched controls. Ventilatory patterns of unrestrained mice were measured in a whole-b...

journal_title：Neuroscience letters

authors： Boudinot E,Tremblay P,Champagnat J,Foutz AS

更新日期：2002-04-26 00:00:00

abstract：:The levels of immunoreactive Leu-enkephalin (ir-Leu-Enk) were measured in acid extract of hearts and lungs of adult normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Heart contents in ir-Leu-Enk were significantly higher in SHR rats (2.67 pmol/g) than in WKY rats (1.5 pmol/g). However, no sign...

journal_title：Neuroscience letters

authors： Dumont M,Lemaire S

更新日期：1988-11-22 00:00:00

abstract：:In an effort to analyze the genetic role of tau in Alzheimer's disease (AD), 17 polymorphisms were identified. Eleven of these polymorphisms were in complete linkage disequilibrium and segregated as two haplotypes, A and B. The A and B haplotypes were investigated in 269 AD cases and 238 controls from two different so...

journal_title：Neuroscience letters

authors： Lilius L,Froelich Fabre S,Basun H,Forsell C,Axelman K,Mattila K,Andreadis A,Viitanen M,Winblad B,Fratiglioni L,Lannfelt L

更新日期：1999-12-17 00:00:00

abstract：:Direct projections from the A1/C1 catecholaminergic cell group in the caudal ventrolateral medulla oblongata to neurons containing vasopressin (VP) in the supraoptic nucleus (SON) were studied electron microscopically by a double-labeling technique which combines anterograde tracing after injection of wheat germ agglu...

journal_title：Neuroscience letters

authors： Shioda S,Shimoda Y,Nakai Y

更新日期：1992-12-14 00:00:00

abstract：:We used quantitative in situ hybridization to study changes in the expression of c-fos following hypoxic-ischemia (H-I) in the neonatal rat brain. 7-day-old rat pups were subjected to a unilateral ligation of the common carotid artery followed by a 2 h 15 min hypoxic period (7.7% O2 in N2). This resulted in the expect...

journal_title：Neuroscience letters

authors： Adén U,Bona E,Hagberg H,Fredholm BB

更新日期：1994-10-24 00:00:00

abstract：:Electrical stimulation in the lateral midbrain reticular formation (LRF) inhibited the responses of spinal dorsal horn neurons to noxious (50 degrees C) skin heating. Systemic administration of naloxone (0.1-2 mg/kg) had no effect on inhibition produced by LRF stimulation in 10 units, while this inhibition was partial...

journal_title：Neuroscience letters

authors： Carstens E,Zimmermann M

更新日期：1980-12-01 00:00:00

abstract：:Inorganic mercury (HgCl2) was administered to adult mice in drinking water (20 mg/l). Animals were sacrificed after one or two years and fixed by whole-body perfusion. Sections of the hypothalamus and neurohypophysis were subjected to silver acetate autometallography for visualization of mercury at light and electron ...

journal_title：Neuroscience letters

authors： Villegas J,Martinez R,Andres A,Crespo D

更新日期：1999-08-20 00:00:00